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CTSS and SERPINB4
Number of citations of the paper that reports this interaction (PMID
10852705
)
4
Data Source:
HPRD
(in vitro)
CTSS
SERPINB4
Gene Name
cathepsin S
serpin peptidase inhibitor, clade B (ovalbumin), member 4
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Extracellular Region
Extracellular Space
Lysosome
Membrane
Endolysosome Lumen
Lysosomal Lumen
Intracellular Membrane-bounded Organelle
Extracellular Space
Cytoplasm
Extracellular Vesicular Exosome
Molecular Function
Fibronectin Binding
Cysteine-type Endopeptidase Activity
Collagen Binding
Laminin Binding
Proteoglycan Binding
Serine-type Endopeptidase Inhibitor Activity
Enzyme Binding
Biological Process
Toll-like Receptor Signaling Pathway
Adaptive Immune Response
Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I
Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-independent
Proteolysis
Immune Response
Antigen Processing And Presentation
Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II
Extracellular Matrix Disassembly
Extracellular Matrix Organization
Collagen Catabolic Process
Basement Membrane Disassembly
Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I
Innate Immune Response
Positive Regulation Of Inflammatory Response
Proteolysis Involved In Cellular Protein Catabolic Process
Cellular Response To Thyroid Hormone Stimulus
Negative Regulation Of Peptidase Activity
Negative Regulation Of Endopeptidase Activity
Regulation Of Proteolysis
Pathways
Toll-Like Receptors Cascades
Trafficking and processing of endosomal TLR
Collagen formation
MHC class II antigen presentation
Endosomal/Vacuolar pathway
Class I MHC mediated antigen processing & presentation
Antigen processing-Cross presentation
Degradation of the extracellular matrix
Assembly of collagen fibrils and other multimeric structures
Adaptive Immune System
Innate Immune System
Drugs
Morpholine-4-Carboxylic Acid [1s-(2-Benzyloxy-1r-Cyano-Ethylcarbamoyl)-3-Methyl-Butyl]Amide
Morpholine-4-Carboxylic Acid (1-(3-Benzenesulfonyl-1-Phenethylallylcarbamoyl)-3-Methylbutyl)-Amide
Morpholine-4-Carboxylic Acid [1-(2-Benzylsulfanyl-1-Formyl-Ethylcarbamoyl)-2-Phenyl-Ethyl]-Amide
N-[1-(AMINOMETHYL)CYCLOPROPYL]-3-(MORPHOLIN-4-YLSULFONYL)-N~2~-[(1S)-2,2,2-TRIFLUORO-1-(4-FLUOROPHENYL)ETHYL]-L-ALANINAMIDE
N-(1-CYANOCYCLOPROPYL)-3-({[(2S)-5-OXOPYRROLIDIN-2-YL]METHYL}SULFONYL)-N~2~-[(1S)-2,2,2-TRIFLUORO-1-(4-FLUOROPHENYL)ETHYL]-L-ALANINAMIDE
N-[1-(AMINOMETHYL)CYCLOPROPYL]-3-(BENZYLSULFONYL)-N~2~-[(1S)-2,2,2-TRIFLUORO-1-(4-HYDROXYPHENYL)ETHYL]-L-ALANINAMIDE
N~2~-1,3-BENZOXAZOL-2-YL-3-CYCLOHEXYL-N-{2-[(4-METHOXYPHENYL)AMINO]ETHYL}-L-ALANINAMIDE
N-[(1S)-1-{1-[(1R,3E)-1-ACETYLPENT-3-EN-1-YL]-1H-1,2,3-TRIAZOL-4-YL}-1,2-DIMETHYLPROPYL]BENZAMIDE
(1R)-2-[(CYANOMETHYL)AMINO]-1-({[2-(DIFLUOROMETHOXY)BENZYL]SULFONYL}METHYL)-2-OXOETHYL MORPHOLINE-4-CARBOXYLATE
2-[(2\',3\',4\'-TRIFLUOROBIPHENYL-2-YL)OXY]ETHANOL
N-[(1S)-2-[(4-cyano-1-methylpiperidin-4-yl)amino]-1-(cyclohexylmethyl)-2-oxoethyl]morpholine-4-carboxamide
N-[(1S)-2-{[(1R)-2-(benzyloxy)-1-cyano-1-methylethyl]amino}-1-(cyclohexylmethyl)-2-oxoethyl]morpholine-4-carboxamide
Diseases
GWAS
Rhegmatogenous retinal detachment (
23585552
)
Protein-Protein Interactions
8 interactors:
BGLAP
CST3
CST5
KNG1
PLCG1
SERPINB3
SERPINB4
SLPI
3 interactors:
CTSG
CTSS
MAPK8
Entrez ID
1520
6318
HPRD ID
00292
02746
Ensembl ID
ENSG00000163131
ENSG00000206073
Uniprot IDs
P25774
P48594
PDB IDs
1BXF
1GLO
1MS6
1NPZ
1NQC
2C0Y
2F1G
2FQ9
2FRA
2FRQ
2FT2
2FUD
2FYE
2G6D
2G7Y
2H7J
2HH5
2HHN
2HXZ
2OP3
2R9M
2R9N
2R9O
3IEJ
3KWN
3MPE
3MPF
3N3G
3N4C
3OVX
Enriched GO Terms of Interacting Partners
?
Negative Regulation Of Endopeptidase Activity
Negative Regulation Of Peptidase Activity
Negative Regulation Of Proteolysis
Negative Regulation Of Protein Processing
Regulation Of Endopeptidase Activity
Negative Regulation Of Hydrolase Activity
Regulation Of Protein Processing
Regulation Of Peptidase Activity
Regulation Of Proteolysis
Negative Regulation Of Catalytic Activity
Negative Regulation Of Cellular Protein Metabolic Process
Negative Regulation Of Protein Metabolic Process
Regulation Of Cellular Protein Metabolic Process
Regulation Of Protein Metabolic Process
Regulation Of Catalytic Activity
Negative Regulation Of Cellular Metabolic Process
Regulation Of Tissue Remodeling
Negative Regulation Of Elastin Catabolic Process
Negative Regulation Of Blood Vessel Remodeling
Negative Regulation Of Collagen Catabolic Process
Response To Vitamin K
Regulation Of Collagen Catabolic Process
Regulation Of Ion Homeostasis
Negative Regulation Of Extracellular Matrix Organization
Negative Regulation Of Extracellular Matrix Disassembly
Regulation Of Metabolic Process
Regulation Of Blood Vessel Remodeling
Response To Hydroxyisoflavone
Negative Regulation Of Multicellular Organismal Metabolic Process
Regulation Of Cellular Process
Positive Regulation Of Renal Sodium Excretion
Negative Regulation Of Glycoprotein Metabolic Process
Extracellular Fibril Organization
Blood Coagulation, Intrinsic Pathway
Positive Regulation Of Urine Volume
Response To Gravity
Negative Regulation Of Tissue Remodeling
Cellular Response To Vitamin D
Positive Regulation Of Blood Vessel Endothelial Cell Migration
Regulation Of Renal Sodium Excretion
Defense Response
Blood Coagulation
Regulation Of Excretion
Hemostasis
Cellular Response To Epidermal Growth Factor Stimulus
Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol
Phospholipid Catabolic Process
Osteoblast Development
Response To Epidermal Growth Factor
Regulation Of Extracellular Matrix Disassembly
Positive Regulation Of Immune Response
Extracellular Matrix Disassembly
Regulation Of Immune Response
Positive Regulation Of Immune System Process
Toll-like Receptor Signaling Pathway
Pattern Recognition Receptor Signaling Pathway
Innate Immune Response-activating Signal Transduction
Activation Of Innate Immune Response
Immune Response
Regulation Of Immune System Process
Positive Regulation Of Innate Immune Response
Defense Response
Neutrophil Mediated Killing Of Gram-positive Bacterium
Basement Membrane Disassembly
Regulation Of Innate Immune Response
Response To Lipopolysaccharide
JUN Phosphorylation
Response To Molecule Of Bacterial Origin
Positive Regulation Of Deacetylase Activity
Extracellular Matrix Organization
Extracellular Structure Organization
Immune System Process
Positive Regulation Of Determination Of Dorsal Identity
Killing By Host Of Symbiont Cells
Immune Response-regulating Signaling Pathway
Response To Bacterium
Response To Organic Substance
Cellular Response To Thyroid Hormone Stimulus
Angiotensin Maturation
Regulation Of Angiotensin Metabolic Process
Cellular Response To Nitric Oxide
Regulation Of Systemic Arterial Blood Pressure By Circulatory Renin-angiotensin
Response To Nitric Oxide
Response To Thyroid Hormone
Basement Membrane Organization
Neutrophil Mediated Immunity
Response To Other Organism
Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway
Cellular Response To Reactive Nitrogen Species
Regulation Of Systemic Arterial Blood Pressure By Renin-angiotensin
Response To Biotic Stimulus
Killing Of Cells Of Other Organism
Response To Stress
Negative Regulation Of Growth Of Symbiont In Host
Innate Immune Response
Defense Response To Fungus
Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway
Response To Lipid
Interaction With Symbiont
Leukocyte Mediated Cytotoxicity
Tagcloud
?
amounts
bacteriuria
capability
capacitance
capacitive
consuming
demand
dissolved
distinguishing
exponential
feasible
fem
finite
gave
giving
ionic
liquids
measurable
portable
proposes
sensor
simulations
solutions
tangible
top
touch
urine
utis
volumes
Tagcloud (Difference)
?
amounts
bacteriuria
capability
capacitance
capacitive
consuming
demand
dissolved
distinguishing
exponential
feasible
fem
finite
gave
giving
ionic
liquids
measurable
portable
proposes
sensor
simulations
solutions
tangible
top
touch
urine
utis
volumes
Tagcloud (Intersection)
?