CTSS and CST5

Number of citations of the paper that reports this interaction (PMID 8083219)
4

Data Source:
BioGRID (pull down)
HPRD (in vitro)

		CTSS	CST5
Gene Name		cathepsin S	cystatin D
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Lysosome Membrane Endolysosome Lumen Lysosomal Lumen Intracellular Membrane-bounded Organelle	Extracellular Region Extracellular Vesicular Exosome
	Molecular Function	Fibronectin Binding Cysteine-type Endopeptidase Activity Collagen Binding Laminin Binding Proteoglycan Binding	Cysteine-type Endopeptidase Inhibitor Activity Protein Binding
	Biological Process	Toll-like Receptor Signaling Pathway Adaptive Immune Response Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-independent Proteolysis Immune Response Antigen Processing And Presentation Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Extracellular Matrix Disassembly Extracellular Matrix Organization Collagen Catabolic Process Basement Membrane Disassembly Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I Innate Immune Response Positive Regulation Of Inflammatory Response Proteolysis Involved In Cellular Protein Catabolic Process Cellular Response To Thyroid Hormone Stimulus	Negative Regulation Of Endopeptidase Activity
Pathways		Toll-Like Receptors Cascades Trafficking and processing of endosomal TLR Collagen formation MHC class II antigen presentation Endosomal/Vacuolar pathway Class I MHC mediated antigen processing & presentation Antigen processing-Cross presentation Degradation of the extracellular matrix Assembly of collagen fibrils and other multimeric structures Adaptive Immune System Innate Immune System
Drugs		Morpholine-4-Carboxylic Acid [1s-(2-Benzyloxy-1r-Cyano-Ethylcarbamoyl)-3-Methyl-Butyl]Amide Morpholine-4-Carboxylic Acid (1-(3-Benzenesulfonyl-1-Phenethylallylcarbamoyl)-3-Methylbutyl)-Amide Morpholine-4-Carboxylic Acid [1-(2-Benzylsulfanyl-1-Formyl-Ethylcarbamoyl)-2-Phenyl-Ethyl]-Amide N-[1-(AMINOMETHYL)CYCLOPROPYL]-3-(MORPHOLIN-4-YLSULFONYL)-N~2~-[(1S)-2,2,2-TRIFLUORO-1-(4-FLUOROPHENYL)ETHYL]-L-ALANINAMIDE N-(1-CYANOCYCLOPROPYL)-3-({[(2S)-5-OXOPYRROLIDIN-2-YL]METHYL}SULFONYL)-N~2~-[(1S)-2,2,2-TRIFLUORO-1-(4-FLUOROPHENYL)ETHYL]-L-ALANINAMIDE N-[1-(AMINOMETHYL)CYCLOPROPYL]-3-(BENZYLSULFONYL)-N~2~-[(1S)-2,2,2-TRIFLUORO-1-(4-HYDROXYPHENYL)ETHYL]-L-ALANINAMIDE N~2~-1,3-BENZOXAZOL-2-YL-3-CYCLOHEXYL-N-{2-[(4-METHOXYPHENYL)AMINO]ETHYL}-L-ALANINAMIDE N-[(1S)-1-{1-[(1R,3E)-1-ACETYLPENT-3-EN-1-YL]-1H-1,2,3-TRIAZOL-4-YL}-1,2-DIMETHYLPROPYL]BENZAMIDE (1R)-2-[(CYANOMETHYL)AMINO]-1-({[2-(DIFLUOROMETHOXY)BENZYL]SULFONYL}METHYL)-2-OXOETHYL MORPHOLINE-4-CARBOXYLATE 2-[(2\',3\',4\'-TRIFLUOROBIPHENYL-2-YL)OXY]ETHANOL N-[(1S)-2-[(4-cyano-1-methylpiperidin-4-yl)amino]-1-(cyclohexylmethyl)-2-oxoethyl]morpholine-4-carboxamide N-[(1S)-2-{[(1R)-2-(benzyloxy)-1-cyano-1-methylethyl]amino}-1-(cyclohexylmethyl)-2-oxoethyl]morpholine-4-carboxamide
Diseases
GWAS		Rhegmatogenous retinal detachment ( 23585552)	Response to TNF antagonist treatment ( 18615156)
Protein-Protein Interactions		8 interactors: BGLAP CST3 CST5 KNG1 PLCG1 SERPINB3 SERPINB4 SLPI	1 interactors: CTSS
Entrez ID		1520	1473
HPRD ID		00292	00463
Ensembl ID		ENSG00000163131	ENSG00000170367
Uniprot IDs		P25774	P28325
PDB IDs		1BXF 1GLO 1MS6 1NPZ 1NQC 2C0Y 2F1G 2FQ9 2FRA 2FRQ 2FT2 2FUD 2FYE 2G6D 2G7Y 2H7J 2HH5 2HHN 2HXZ 2OP3 2R9M 2R9N 2R9O 3IEJ 3KWN 3MPE 3MPF 3N3G 3N4C 3OVX	1RN7 1ROA
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Endopeptidase Activity Negative Regulation Of Peptidase Activity Negative Regulation Of Proteolysis Negative Regulation Of Protein Processing Regulation Of Endopeptidase Activity Negative Regulation Of Hydrolase Activity Regulation Of Protein Processing Regulation Of Peptidase Activity Regulation Of Proteolysis Negative Regulation Of Catalytic Activity Negative Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process Regulation Of Catalytic Activity Negative Regulation Of Cellular Metabolic Process Regulation Of Tissue Remodeling Negative Regulation Of Elastin Catabolic Process Negative Regulation Of Blood Vessel Remodeling Negative Regulation Of Collagen Catabolic Process Response To Vitamin K Regulation Of Collagen Catabolic Process Regulation Of Ion Homeostasis Negative Regulation Of Extracellular Matrix Organization Negative Regulation Of Extracellular Matrix Disassembly Regulation Of Metabolic Process Regulation Of Blood Vessel Remodeling Response To Hydroxyisoflavone Negative Regulation Of Multicellular Organismal Metabolic Process Regulation Of Cellular Process Positive Regulation Of Renal Sodium Excretion Negative Regulation Of Glycoprotein Metabolic Process Extracellular Fibril Organization Blood Coagulation, Intrinsic Pathway Positive Regulation Of Urine Volume Response To Gravity Negative Regulation Of Tissue Remodeling Cellular Response To Vitamin D Positive Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of Renal Sodium Excretion Defense Response Blood Coagulation Regulation Of Excretion Hemostasis Cellular Response To Epidermal Growth Factor Stimulus Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Phospholipid Catabolic Process Osteoblast Development Response To Epidermal Growth Factor Regulation Of Extracellular Matrix Disassembly	Basement Membrane Disassembly Cellular Response To Thyroid Hormone Stimulus Response To Thyroid Hormone Basement Membrane Organization Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-independent Collagen Catabolic Process Collagen Metabolic Process Multicellular Organismal Macromolecule Metabolic Process Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Multicellular Organismal Metabolic Process Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Extracellular Matrix Disassembly Positive Regulation Of Inflammatory Response Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Toll-like Receptor Signaling Pathway Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Positive Regulation Of Innate Immune Response Antigen Processing And Presentation Of Peptide Antigen Regulation Of Innate Immune Response Adaptive Immune Response Regulation Of Inflammatory Response Antigen Processing And Presentation Extracellular Matrix Organization Extracellular Structure Organization Immune Response-regulating Signaling Pathway Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Cellular Response To Hormone Stimulus Protein Catabolic Process Positive Regulation Of Immune Response
Tagcloud ?		amounts bacteriuria capability capacitance capacitive consuming demand dissolved distinguishing exponential feasible fem finite gave giving ionic liquids measurable portable proposes sensor simulations solutions tangible top touch urine utis volumes	2d3 abrogates adh adhesive coiled cyp24 cystatin dihydroxyvitamin disrupts epithelioid ht29 hydroxylase islands junction msk n19 occludin oh p38mapk rho rhoa ro318220 rock sn sw480 tight transiently vinculin y27632
Tagcloud (Difference) ?		amounts bacteriuria capability capacitance capacitive consuming demand dissolved distinguishing exponential feasible fem finite gave giving ionic liquids measurable portable proposes sensor simulations solutions tangible top touch urine utis volumes	2d3 abrogates adh adhesive coiled cyp24 cystatin dihydroxyvitamin disrupts epithelioid ht29 hydroxylase islands junction msk n19 occludin oh p38mapk rho rhoa ro318220 rock sn sw480 tight transiently vinculin y27632
Tagcloud (Intersection) ?