CTSS and CST5

Number of citations of the paper that reports this interaction (PubMedID 8083219)
0

Data Source:
BioGRID (pull down)
HPRD (in vitro)

		CTSS	CST5
Description		cathepsin S	cystatin D
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Lysosome Late Endosome Extracellular Matrix Cytoplasmic Vesicle Endolysosome Lumen Lysosomal Lumen Phagocytic Vesicle Tertiary Granule Lumen Ficolin-1-rich Granule Lumen	Extracellular Region Extracellular Space Cytoplasm Vesicle Extracellular Exosome
	Molecular Function	Fibronectin Binding Cysteine-type Endopeptidase Activity Serine-type Endopeptidase Activity Protein Binding Collagen Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity Laminin Binding Proteoglycan Binding	Cysteine-type Endopeptidase Inhibitor Activity Protein Binding Peptidase Inhibitor Activity
	Biological Process	Toll-like Receptor Signaling Pathway Adaptive Immune Response Regulation Of Antigen Processing And Presentation Proteolysis Immune Response Response To Acidic PH Protein Processing Antigen Processing And Presentation Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Extracellular Matrix Disassembly Collagen Catabolic Process Basement Membrane Disassembly Antigen Processing And Presentation Of Peptide Antigen Proteolysis Involved In Protein Catabolic Process Cellular Response To Thyroid Hormone Stimulus Positive Regulation Of Cation Channel Activity
Pathways		Endosomal/Vacuolar pathway Degradation of the extracellular matrix Degradation of the extracellular matrix Trafficking and processing of endosomal TLR Assembly of collagen fibrils and other multimeric structures MHC class II antigen presentation Neutrophil degranulation Degradation of CDH1
Drugs		Morpholine-4-Carboxylic Acid [1s-(2-Benzyloxy-1r-Cyano-Ethylcarbamoyl)-3-Methyl-Butyl]Amide Morpholine-4-Carboxylic Acid (1-(3-Benzenesulfonyl-1-Phenethylallylcarbamoyl)-3-Methylbutyl)-Amide Morpholine-4-Carboxylic Acid [1-(2-Benzylsulfanyl-1-Formyl-Ethylcarbamoyl)-2-Phenyl-Ethyl]-Amide N-[1-(AMINOMETHYL)CYCLOPROPYL]-3-(MORPHOLIN-4-YLSULFONYL)-N~2~-[(1S)-2,2,2-TRIFLUORO-1-(4-FLUOROPHENYL)ETHYL]-L-ALANINAMIDE N-(1-CYANOCYCLOPROPYL)-3-({[(2S)-5-OXOPYRROLIDIN-2-YL]METHYL}SULFONYL)-N~2~-[(1S)-2,2,2-TRIFLUORO-1-(4-FLUOROPHENYL)ETHYL]-L-ALANINAMIDE N-[1-(AMINOMETHYL)CYCLOPROPYL]-3-(BENZYLSULFONYL)-N~2~-[(1S)-2,2,2-TRIFLUORO-1-(4-HYDROXYPHENYL)ETHYL]-L-ALANINAMIDE N~2~-1,3-BENZOXAZOL-2-YL-3-CYCLOHEXYL-N-{2-[(4-METHOXYPHENYL)AMINO]ETHYL}-L-ALANINAMIDE N-[(1S)-1-{1-[(1R,3E)-1-ACETYLPENT-3-EN-1-YL]-1H-1,2,3-TRIAZOL-4-YL}-1,2-DIMETHYLPROPYL]BENZAMIDE (1R)-2-[(CYANOMETHYL)AMINO]-1-({[2-(DIFLUOROMETHOXY)BENZYL]SULFONYL}METHYL)-2-OXOETHYL MORPHOLINE-4-CARBOXYLATE 2-[(2',3',4'-TRIFLUOROBIPHENYL-2-YL)OXY]ETHANOL N-[(1S)-2-[(4-cyano-1-methylpiperidin-4-yl)amino]-1-(cyclohexylmethyl)-2-oxoethyl]morpholine-4-carboxamide N-[(1S)-2-{[(1R)-2-(benzyloxy)-1-cyano-1-methylethyl]amino}-1-(cyclohexylmethyl)-2-oxoethyl]morpholine-4-carboxamide Fostamatinib
Diseases
GWAS		Aspartate aminotransferase levels ( 33547301) Basal cell carcinoma ( 33549134) Blood protein levels ( 30072576) Body mass index ( 26426971) Caffeine consumption from coffee ( 33287642) Caffeine consumption from coffee or tea ( 33287642) Congenital left-sided heart lesions ( 26965164) Coronary artery disease ( 32469254) Fat body mass ( 24064335) Lymphocyte percentage of white cells ( 32888494) Mean platelet volume ( 32888494) Rhegmatogenous retinal detachment ( 23585552)	Blood protein levels ( 30072576) Body mass index (change over time) in cancer or chronic obstructive pulmonary disease ( 28044437) Disease progression in age-related macular degeneration (adjusted for baseline) ( 29346644) Response to TNF antagonist treatment ( 18615156)
Interacting Genes		9 interacting genes: ANXA2 BGLAP CST3 CST5 KNG1 PLCG1 SERPINB3 SERPINB4 SLPI	1 interacting genes: CTSS
Entrez ID		1520	1473
HPRD ID		00292	00463
Ensembl ID		ENSG00000163131	ENSG00000170367
Uniprot IDs		P25774	P28325
PDB IDs		1GLO 1MS6 1NPZ 1NQC 2C0Y 2F1G 2FQ9 2FRA 2FRQ 2FT2 2FUD 2FYE 2G6D 2G7Y 2H7J 2HH5 2HHN 2HXZ 2OP3 2R9M 2R9N 2R9O 3IEJ 3N3G 3N4C 3OVX 4P6E 4P6G 5QBU 5QBV 5QBW 5QBX 5QBY 5QBZ 5QC0 5QC1 5QC2 5QC3 5QC4 5QC5 5QC6 5QC7 5QC8 5QC9 5QCA 5QCB 5QCC 5QCD 5QCE 5QCF 5QCG 5QCH 5QCI 5QCJ 6YYN 6YYO 6YYP 6YYQ 6YYR 8PI3 8RND 9GJ2	1RN7 1ROA
Enriched GO Terms of Interacting Partners?		Peptidase Inhibitor Activity Cysteine-type Endopeptidase Inhibitor Activity Endopeptidase Inhibitor Activity Vesicle Extracellular Space Serine-type Endopeptidase Inhibitor Activity Protease Binding Regulation Of Proteolysis Negative Regulation Of Proteolysis Negative Regulation Of Protein Metabolic Process Extracellular Region Negative Regulation Of Peptidase Activity Negative Regulation Of Hydrolase Activity Extracellular Exosome Negative Regulation Of Blood Coagulation Negative Regulation Of Hemostasis Negative Regulation Of Coagulation Endoplasmic Reticulum Lumen Regulation Of Protein Metabolic Process Negative Regulation Of Collagen Catabolic Process Negative Regulation Of Elastin Catabolic Process Negative Regulation Of Wound Healing Regulation Of Hemostasis Regulation Of Blood Coagulation Response To Activity Regulation Of Tissue Remodeling Positive Regulation Of Receptor-mediated Endocytosis Involved In Cholesterol Transport Azurophil Granule Lumen AnxA2-p11 Complex PCSK9-AnxA2 Complex Negative Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Negative Regulation Of Bone Development Structural Constituent Of Bone Negative Regulation Of Blood Vessel Remodeling Calcium-dependent Phospholipase C Activity Extracellular Matrix Regulation Of Multicellular Organismal Process Negative Regulation Of Receptor Catabolic Process Positive Regulation Of Intracellular Cholesterol Transport Hormone Activity Negative Regulation Of Protein Catabolic Process Positive Regulation Of Low-density Lipoprotein Particle Clearance Positive Regulation Of Plasma Membrane Repair Positive Regulation Of Intracellular Lipid Transport Negative Regulation Of Multicellular Organismal Process Hydroxyapatite Binding Regulation Of Collagen Catabolic Process Regulation Of Wound Healing Myelin Sheath Adaxonal Region Response To Vitamin K	Collagen Catabolic Process Endolysosome Lumen Positive Regulation Of Ion Transmembrane Transporter Activity Response To Acidic PH Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Fibronectin Binding Cellular Response To Thyroid Hormone Stimulus Regulation Of Antigen Processing And Presentation Laminin Binding Basement Membrane Disassembly Response To PH Positive Regulation Of Transporter Activity Antigen Processing And Presentation Of Exogenous Peptide Antigen Response To Thyroid Hormone Basement Membrane Organization Proteoglycan Binding Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Positive Regulation Of Cation Channel Activity Antigen Processing And Presentation Of Exogenous Antigen Toll-like Receptor Signaling Pathway Extracellular Matrix Disassembly Tertiary Granule Lumen Antigen Processing And Presentation Of Peptide Antigen Collagen Binding Collagen Metabolic Process Cysteine-type Endopeptidase Activity Regulation Of Transmembrane Transporter Activity Phagocytic Vesicle Regulation Of Monoatomic Ion Transmembrane Transporter Activity Lysosomal Lumen Antigen Processing And Presentation Positive Regulation Of Cation Transmembrane Transport Ficolin-1-rich Granule Lumen Positive Regulation Of Monoatomic Ion Transmembrane Transport Cysteine-type Peptidase Activity Serine-type Endopeptidase Activity Late Endosome Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signaling Pathway Protein Processing Positive Regulation Of Monoatomic Ion Transport Activation Of Innate Immune Response Extracellular Matrix Organization Extracellular Structure Organization Regulation Of Monoatomic Cation Transmembrane Transport Regulation Of Monoatomic Ion Transmembrane Transport Adaptive Immune Response Positive Regulation Of Innate Immune Response Protein Maturation
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