CTSE and A2M

Number of citations of the paper that reports this interaction (PMID 12631277)
2

Data Source:
HPRD (in vitro)

		CTSE	A2M
Gene Name		cathepsin E	alpha-2-macroglobulin
Image
Gene Ontology Annotations	Cellular Component	Endosome Extracellular Vesicular Exosome	Extracellular Region Cytosol Platelet Alpha Granule Lumen Extracellular Vesicular Exosome Blood Microparticle
	Molecular Function	Aspartic-type Endopeptidase Activity Protein Homodimerization Activity	Protease Binding Serine-type Endopeptidase Inhibitor Activity Receptor Binding Protein Binding Growth Factor Binding Enzyme Binding Interleukin-8 Binding Interleukin-1 Binding Tumor Necrosis Factor Binding Calcium-dependent Protein Binding
	Biological Process	Proteolysis Digestion Protein Autoprocessing Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II	Negative Regulation Of Complement Activation, Lectin Pathway Platelet Degranulation Small GTPase Mediated Signal Transduction Blood Coagulation Blood Coagulation, Intrinsic Pathway Negative Regulation Of Endopeptidase Activity Extracellular Matrix Disassembly Platelet Activation Extracellular Matrix Organization Stem Cell Differentiation Regulation Of Small GTPase Mediated Signal Transduction
Pathways		MHC class II antigen presentation Adaptive Immune System	Lipoprotein metabolism Metabolism of lipids and lipoproteins Platelet degranulation Lipid digestion, mobilization, and transport Degradation of the extracellular matrix Formation of Fibrin Clot (Clotting Cascade) Rho GTPase cycle Intrinsic Pathway HDL-mediated lipid transport Response to elevated platelet cytosolic Ca2+ Signaling by Rho GTPases Platelet activation, signaling and aggregation
Drugs			Becaplermin Bacitracin Ocriplasmin
Diseases
GWAS
Protein-Protein Interactions		5 interactors: A2M BAG6 EDN3 EMG1 INS	93 interactors: ACTB ADAM19 ADAMTS1 AMBP ANXA6 ANXA7 AP1M2 APOE APP ATF7IP ATP1A1 B2M C11orf58 CDC37 CDC42 CDK2AP2 CDKN1A CELA1 CPB2 CTSB CTSE CYP2C18 CYP2C8 DNAJB1 ECSIT EGLN2 ELAVL3 ENO2 EVI5L EXOSC1 FARSA FBXL12 FBXW4 FIS1 GCDH GEM GRB2 H2AFX HMOX2 HSPA5 IFIT3 IFIT5 IGSF8 IL10 IL1B IL4 KLK13 KLK2 KLK3 LCAT LEP LONP1 LRP1 LYZ MAST1 MGEA5 MLST8 MMP2 MYOC NCDN NGF NOS3 NUDT21 PAEP PAXIP1 PDGFA PDGFB PRAM1 PRDX2 RAB3A RAD23A RAP1B RETN RHEB RNF32 RPP14 SEPT8 SHBG SMN1 STAMBPL1 SWSAP1 TGFBI TGIF1 TGM2 TK1 TNFRSF14 TRAPPC5 TSC22D1 TTR TUBA1B TYRO3 UFD1L UMPS
Entrez ID		1510	2
HPRD ID		00294	00072
Ensembl ID		ENSG00000196188	ENSG00000175899
Uniprot IDs		P14091	P01023
PDB IDs		1LCG 1TZS	1BV8 2P9R 4ACQ
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Innate Immune Response Positive Regulation Of Mitotic Nuclear Division Negative Regulation Of Proteolysis Negative Regulation Of Protein Processing Regulation Of Protein Processing Regulation Of Acute Inflammatory Response Intracellular Signal Transduction Positive Regulation Of Hormone Secretion Regulation Of Proteolysis Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Protein Catabolic Process Positive Regulation Of Mitotic Cell Cycle Regulation Of Mitotic Nuclear Division Positive Regulation Of Cell Division Negative Regulation Of Immune Response Regulation Of Protein Metabolic Process Negative Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Glycogen Catabolic Process Negative Regulation Of Complement Activation, Lectin Pathway Negative Regulation Of Protein Metabolic Process Negative Regulation Of Respiratory Burst Involved In Inflammatory Response Negative Regulation Of NAD(P)H Oxidase Activity Regulation Of Behavior Vein Smooth Muscle Contraction Positive Regulation Of Cell Cycle Process Regulation Of Systemic Arterial Blood Pressure By Endothelin Regulation Of Innate Immune Response Regulation Of Cell Division Positive Regulation Of Brown Fat Cell Differentiation Regulation Of Hormone Secretion Regulation Of Brown Fat Cell Differentiation Cellular Magnesium Ion Homeostasis Regulation Of NAD(P)H Oxidase Activity Negative Regulation Of Feeding Behavior Tail-anchored Membrane Protein Insertion Into ER Membrane Regulation Of Inflammatory Response Positive Regulation Of Cell Cycle Regulation Of Immune System Process Positive Regulation Of Respiratory Burst Negative Regulation Of Vasodilation Stem Cell Differentiation Protein Insertion Into ER Membrane Positive Regulation Of Secretion Positive Regulation Of Cell Migration Negative Regulation Of Protein Oligomerization Regulation Of Glycogen Catabolic Process Positive Regulation Of Cell Motility Positive Regulation Of Cellular Component Movement Positive Regulation Of Locomotion Regulation Of Cell Proliferation	Response To Abiotic Stimulus Response To Stress Regulation Of Cell Activation Response To Stimulus Response To External Stimulus Developmental Process Anatomical Structure Development Regulation Of Immune Response Response To Organic Substance Cellular Response To Stimulus Response To Drug System Development Multicellular Organismal Development Hemostasis Defense Response Regulation Of Cellular Component Organization Regulation Of Body Fluid Levels Regulation Of Immune System Process Blood Coagulation Negative Regulation Of Blood Coagulation Regulation Of Cell Proliferation Positive Regulation Of Protein Metabolic Process Negative Regulation Of Coagulation Organ Development Cellular Response To Organic Substance Negative Regulation Of Wound Healing Regulation Of Protein Metabolic Process Response To Hormone Catabolic Process Negative Regulation Of Platelet Activation Positive Regulation Of Cellular Protein Metabolic Process Platelet Activation Phosphatidylinositol-mediated Signaling Immune Response Regulation Of Phosphorylation Regulation Of Signaling Reproductive Process Positive Regulation Of Intracellular Signal Transduction Regulation Of Apoptotic Process Positive Regulation Of DNA Metabolic Process Anatomical Structure Morphogenesis Regulation Of Phosphorus Metabolic Process Cell Surface Receptor Signaling Pathway Innate Immune Response Response To Wounding Positive Regulation Of Cell Activation Regulation Of Lymphocyte Activation Regulation Of Cellular Amino Acid Metabolic Process Regulation Of Cellular Protein Metabolic Process Wound Healing
Tagcloud ?			a1at aptt clauss coaliza eclt euglobulin fbg fibrinolysis fibrinolytic foetopathy foetus gdm haemostasis hemocoagulation interleukins kabi les leucocytic macroglobulin microturbidimetry orm orosomucoid prea prealbumin proteinases thrombocytes thrombophilia varicosities wither
Tagcloud (Difference) ?			a1at aptt clauss coaliza eclt euglobulin fbg fibrinolysis fibrinolytic foetopathy foetus gdm haemostasis hemocoagulation interleukins kabi les leucocytic macroglobulin microturbidimetry orm orosomucoid prea prealbumin proteinases thrombocytes thrombophilia varicosities wither
Tagcloud (Intersection) ?