CTSE and EDN3

Number of citations of the paper that reports this interaction (PMID 2226872)
5

Data Source:
HPRD (in vitro)

		CTSE	EDN3
Gene Name		cathepsin E	endothelin 3
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Endosome Extracellular Vesicular Exosome	Extracellular Region Extracellular Space
	Molecular Function	Aspartic-type Endopeptidase Activity Protein Homodimerization Activity	Receptor Binding Hormone Activity
	Biological Process	Proteolysis Digestion Protein Autoprocessing Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II	Neural Crest Cell Migration Positive Regulation Of Leukocyte Chemotaxis Regulation Of Systemic Arterial Blood Pressure By Endothelin Cellular Calcium Ion Homeostasis Signal Transduction Cell Surface Receptor Signaling Pathway Cell-cell Signaling Multicellular Organismal Development Blood Circulation Positive Regulation Of Cell Proliferation Positive Regulation Of Heart Rate Cellular Magnesium Ion Homeostasis Artery Smooth Muscle Contraction Vein Smooth Muscle Contraction Regulation Of Vasoconstriction Peptide Hormone Secretion Neuron Differentiation Melanocyte Differentiation Neutrophil Chemotaxis Vasoconstriction Positive Regulation Of MAP Kinase Activity Positive Regulation Of Mitotic Nuclear Division Positive Regulation Of Hormone Secretion Inositol Phosphate-mediated Signaling Regulation Of Developmental Pigmentation Positive Regulation Of Potassium Ion Transmembrane Transport
Pathways		MHC class II antigen presentation Adaptive Immune System	Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) G alpha (q) signalling events G alpha (q) signalling events Signaling by GPCR GPCR downstream signaling Peptide ligand-binding receptors Gastrin-CREB signalling pathway via PKC and MAPK Class A/1 (Rhodopsin-like receptors) Metabolic disorders of biological oxidation enzymes GPCR ligand binding
Drugs
Diseases
GWAS			Blood pressure ( 21909110) Diastolic blood pressure ( 21909115) Hypertension ( 19430479 21909115) Response to diuretic therapy in hypertension ( 23753411) Systolic blood pressure ( 21909115)
Protein-Protein Interactions		5 interactors: A2M BAG6 EDN3 EMG1 INS	5 interactors: CMA1 CTSE EDNRA EDNRB KEL
Entrez ID		1510	1908
HPRD ID		00294	00570
Ensembl ID		ENSG00000196188	ENSG00000124205
Uniprot IDs		P14091	P14138 Q4FAT2
PDB IDs		1LCG 1TZS
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Innate Immune Response Positive Regulation Of Mitotic Nuclear Division Negative Regulation Of Proteolysis Negative Regulation Of Protein Processing Regulation Of Protein Processing Regulation Of Acute Inflammatory Response Intracellular Signal Transduction Positive Regulation Of Hormone Secretion Regulation Of Proteolysis Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Protein Catabolic Process Positive Regulation Of Mitotic Cell Cycle Regulation Of Mitotic Nuclear Division Positive Regulation Of Cell Division Negative Regulation Of Immune Response Regulation Of Protein Metabolic Process Negative Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Glycogen Catabolic Process Negative Regulation Of Complement Activation, Lectin Pathway Negative Regulation Of Protein Metabolic Process Negative Regulation Of Respiratory Burst Involved In Inflammatory Response Negative Regulation Of NAD(P)H Oxidase Activity Regulation Of Behavior Vein Smooth Muscle Contraction Positive Regulation Of Cell Cycle Process Regulation Of Systemic Arterial Blood Pressure By Endothelin Regulation Of Innate Immune Response Regulation Of Cell Division Positive Regulation Of Brown Fat Cell Differentiation Regulation Of Hormone Secretion Regulation Of Brown Fat Cell Differentiation Cellular Magnesium Ion Homeostasis Regulation Of NAD(P)H Oxidase Activity Negative Regulation Of Feeding Behavior Tail-anchored Membrane Protein Insertion Into ER Membrane Regulation Of Inflammatory Response Positive Regulation Of Cell Cycle Regulation Of Immune System Process Positive Regulation Of Respiratory Burst Negative Regulation Of Vasodilation Stem Cell Differentiation Protein Insertion Into ER Membrane Positive Regulation Of Secretion Positive Regulation Of Cell Migration Negative Regulation Of Protein Oligomerization Regulation Of Glycogen Catabolic Process Positive Regulation Of Cell Motility Positive Regulation Of Cellular Component Movement Positive Regulation Of Locomotion Regulation Of Cell Proliferation	Vasoconstriction Endothelin Receptor Signaling Pathway Blood Circulation Regulation Of Blood Vessel Size Regulation Of Tube Size Cellular Chemical Homeostasis Enteric Nervous System Development Vascular Smooth Muscle Contraction Cellular Homeostasis Regulation Of Blood Pressure Chemical Homeostasis Negative Regulation Of CAMP Biosynthetic Process Regulation Of Inflammatory Response Negative Regulation Of CAMP Metabolic Process Cellular Calcium Ion Homeostasis Calcium Ion Homeostasis Negative Regulation Of Nucleotide Metabolic Process Autonomic Nervous System Development Cellular Metal Ion Homeostasis Homeostatic Process Regulation Of Adenylate Cyclase Activity Cellular Cation Homeostasis Smooth Muscle Contraction Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Cellular Ion Homeostasis Regulation Of Cyclase Activity Metal Ion Homeostasis Neural Crest Cell Development Neural Crest Cell Differentiation Ion Homeostasis Regulation Of CAMP Biosynthetic Process Sensory Perception Of Pain Renal System Process Regulation Of CAMP Metabolic Process Enteric Smooth Muscle Cell Differentiation Interleukin-1 Beta Biosynthetic Process Mesenchymal Cell Development Mesenchymal Cell Differentiation Posterior Midgut Development Nervous System Development Positive Regulation Of Cytosolic Calcium Ion Concentration Regulation Of Ion Homeostasis Cytosolic Calcium Ion Homeostasis Smooth Muscle Cell Proliferation Negative Regulation Of Neuron Maturation Mesenchyme Development Vein Smooth Muscle Contraction Fibroblast Proliferation Penile Erection Muscle Contraction
Tagcloud ?			agouti albinism asip atf1 delta25 dopachrome edn1 ednrb exoc2 exocyst kitlg ludwigshafen mc1r microphthalmia oca2 oculocutaneous pigmentation prkacb prkacg prkar1a prkar2a prkar2b proopiomelanocortin slc24a4 slc45a2 tautomerase tpcn2 tubb3 tyrp1
Tagcloud (Difference) ?			agouti albinism asip atf1 delta25 dopachrome edn1 ednrb exoc2 exocyst kitlg ludwigshafen mc1r microphthalmia oca2 oculocutaneous pigmentation prkacb prkacg prkar1a prkar2a prkar2b proopiomelanocortin slc24a4 slc45a2 tautomerase tpcn2 tubb3 tyrp1
Tagcloud (Intersection) ?