CTSE and EMG1

Number of citations of the paper that reports this interaction (PubMedID 16169070)
0

Data Source:
HPRD (two hybrid)

		CTSE	EMG1
Description		cathepsin E	EMG1 N1-specific pseudouridine methyltransferase
Image
GO Annotations	Cellular Component	Endosome	Nucleus Nucleoplasm Chromosome Nucleolus Cytoplasm Small-subunit Processome
	Molecular Function	Aspartic-type Endopeptidase Activity Peptidase Activity Hydrolase Activity Identical Protein Binding	RNA Binding Protein Binding Methyltransferase Activity Transferase Activity RRNA Binding Identical Protein Binding RRNA (pseudouridine) Methyltransferase Activity
	Biological Process	Proteolysis Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II	Blastocyst Development RRNA Processing Nucleologenesis Methylation Ribosome Biogenesis Ribosomal Small Subunit Biogenesis RRNA Base Methylation
Pathways		MHC class II antigen presentation	rRNA modification in the nucleus and cytosol Major pathway of rRNA processing in the nucleolus and cytosol
Drugs
Diseases			Bowen-Conradi syndrome (BCS)
GWAS
Interacting Genes		5 interacting genes: A2M BAG6 EDN3 EMG1 INS	20 interacting genes: ANXA3 APP CEBPA CFTR CTSE FAM74A4 FAM98A HIVEP1 HSD3B7 IL7R KHDRBS1 MCPH1 NAA80 PRC1 PSMB7 PSME1 SLC25A38 SUMO2 ZCCHC9 ZNF768
Entrez ID		1510	10436
HPRD ID		00294	12803
Ensembl ID		ENSG00000196188	ENSG00000126749
Uniprot IDs		A0A7P0MPN9 B4DNU8 P14091	Q92979
PDB IDs		1TZS	5FAI 7MQ8 7MQ9 7MQA
Enriched GO Terms of Interacting Partners?		Signaling Receptor Binding Negative Regulation Of Innate Immune Response Protease Binding Interleukin-8 Binding Negative Regulation Of Complement Activation, Lectin Pathway Potassium Ion Transmembrane Transport Blood Vessel Diameter Maintenance Vein Smooth Muscle Contraction Endothelin B Receptor Binding Regulation Of Tube Size Regulation Of Nuclear Division Regulation Of Mitotic Nuclear Division Hormone Activity Positive Regulation Of Mitotic Nuclear Division Positive Regulation Of Hormone Secretion Alpha-beta T Cell Activation Positive Regulation Of Nitric-oxide Synthase Activity Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Negative Regulation Of Proteolysis Receptor Ligand Activity Negative Regulation Of Protein Catabolic Process Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Glycogen Catabolic Process Endoplasmic Reticulum Stress-induced Pre-emptive Quality Control Maintenance Of Unfolded Protein BAT3 Complex RRNA (pseudouridine) Methyltransferase Activity Nucleologenesis Regulation Of Immune System Process Potassium Ion Transport Negative Regulation Of Respiratory Burst Involved In Inflammatory Response Positive Regulation Of Nitric Oxide Mediated Signal Transduction Positive Regulation Of Dendritic Spine Maintenance Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Systemic Arterial Blood Pressure By Endothelin Intracellular Magnesium Ion Homeostasis Negative Regulation Of Respiratory Burst Nucleolus Organization Tumor Necrosis Factor Binding Interleukin-1 Binding Negative Regulation Of Feeding Behavior Regulation Of Nitric-oxide Synthase Activity Negative Regulation Of Immune Response Regulation Of Respiratory Burst Involved In Inflammatory Response Regulation Of Glycogen Catabolic Process Internal Peptidyl-lysine Acetylation Positive Regulation Of Respiratory Burst Nitric Oxide-cGMP-mediated Signaling NK T Cell Activation RRNA Base Methylation
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