CTSE and EMG1

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
HPRD (two hybrid)

		CTSE	EMG1
Gene Name		cathepsin E	EMG1 N1-specific pseudouridine methyltransferase
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Endosome Extracellular Vesicular Exosome	Nucleus Nucleolus Cytoplasm
	Molecular Function	Aspartic-type Endopeptidase Activity Protein Homodimerization Activity	RNA Binding RRNA Binding Poly(A) RNA Binding RRNA (pseudouridine) Methyltransferase Activity
	Biological Process	Proteolysis Digestion Protein Autoprocessing Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II	RRNA Processing RRNA Methylation Ribosomal Small Subunit Biogenesis
Pathways		MHC class II antigen presentation Adaptive Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		5 interactors: A2M BAG6 EDN3 EMG1 INS	11 interactors: ANXA3 APP CTSE FAM74A4 HIVEP1 IL7R KHDRBS1 NAT6 PSMB7 PSME1 SLC25A38
Entrez ID		1510	10436
HPRD ID		00294	12803
Ensembl ID		ENSG00000196188	ENSG00000126749
Uniprot IDs		P14091	Q92979
PDB IDs		1LCG 1TZS
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Innate Immune Response Positive Regulation Of Mitotic Nuclear Division Negative Regulation Of Proteolysis Negative Regulation Of Protein Processing Regulation Of Protein Processing Regulation Of Acute Inflammatory Response Intracellular Signal Transduction Positive Regulation Of Hormone Secretion Regulation Of Proteolysis Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Protein Catabolic Process Positive Regulation Of Mitotic Cell Cycle Regulation Of Mitotic Nuclear Division Positive Regulation Of Cell Division Negative Regulation Of Immune Response Regulation Of Protein Metabolic Process Negative Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Glycogen Catabolic Process Negative Regulation Of Complement Activation, Lectin Pathway Negative Regulation Of Protein Metabolic Process Negative Regulation Of Respiratory Burst Involved In Inflammatory Response Negative Regulation Of NAD(P)H Oxidase Activity Regulation Of Behavior Vein Smooth Muscle Contraction Positive Regulation Of Cell Cycle Process Regulation Of Systemic Arterial Blood Pressure By Endothelin Regulation Of Innate Immune Response Regulation Of Cell Division Positive Regulation Of Brown Fat Cell Differentiation Regulation Of Hormone Secretion Regulation Of Brown Fat Cell Differentiation Cellular Magnesium Ion Homeostasis Regulation Of NAD(P)H Oxidase Activity Negative Regulation Of Feeding Behavior Tail-anchored Membrane Protein Insertion Into ER Membrane Regulation Of Inflammatory Response Positive Regulation Of Cell Cycle Regulation Of Immune System Process Positive Regulation Of Respiratory Burst Negative Regulation Of Vasodilation Stem Cell Differentiation Protein Insertion Into ER Membrane Positive Regulation Of Secretion Positive Regulation Of Cell Migration Negative Regulation Of Protein Oligomerization Regulation Of Glycogen Catabolic Process Positive Regulation Of Cell Motility Positive Regulation Of Cellular Component Movement Positive Regulation Of Locomotion Regulation Of Cell Proliferation	Immune System Process Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Cell Cycle Process Antigen Processing And Presentation Of Peptide Antigen Regulation Of Cell Cycle Phase Transition Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Positive Regulation Of Cell Cycle Antigen Processing And Presentation Negative Regulation Of Catalytic Activity Positive Regulation Of Proteolysis Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Signal Transduction Involved In Mitotic G1 DNA Damage Checkpoint Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Signal Transduction Involved In DNA Damage Checkpoint Signal Transduction Involved In Cell Cycle Checkpoint Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Negative Regulation Of Ubiquitin-protein Transferase Activity Regulation Of Cell Cycle Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Mitotic G1 DNA Damage Checkpoint Positive Regulation Of Ubiquitin-protein Transferase Activity Mitotic G1/S Transition Checkpoint G1 DNA Damage Checkpoint Positive Regulation Of Cell Cycle Arrest Positive Regulation Of Ligase Activity Regulation Of Cellular Amino Acid Metabolic Process DNA Damage Response, Signal Transduction By P53 Class Mediator Regulation Of Mitotic Cell Cycle Positive Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Regulation Of Ubiquitin-protein Transferase Activity Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Signal Transduction In Response To DNA Damage Mitotic DNA Damage Checkpoint Negative Regulation Of Cell Cycle Regulation Of Cell Cycle Arrest Positive Regulation Of Cellular Protein Metabolic Process Mitotic DNA Integrity Checkpoint Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Protein Ubiquitination Interleukin-7-mediated Signaling Pathway Positive Regulation Of RNA Export From Nucleus Synaptic Growth At Neuromuscular Junction Negative Regulation Of Cellular Metabolic Process Regulation Of Cell Cycle Process Regulation Of Cellular Ketone Metabolic Process Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent Signal Transduction By P53 Class Mediator Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I
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