CTGF and FBLN1

Number of citations of the paper that reports this interaction (PMID 9927660)
41

Data Source:
BioGRID (pull down)

		CTGF	FBLN1
Gene Name		connective tissue growth factor	fibulin 1
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Proteinaceous Extracellular Matrix Extracellular Space Golgi Apparatus Cis-Golgi Network Cytosol Plasma Membrane Cell Cortex Intracellular Membrane-bounded Organelle Perinuclear Region Of Cytoplasm	Extracellular Region Proteinaceous Extracellular Matrix Basement Membrane Extracellular Space Extracellular Matrix Extracellular Vesicular Exosome
	Molecular Function	Fibronectin Binding Integrin Binding Protein Binding Insulin-like Growth Factor Binding Growth Factor Activity Heparin Binding	Extracellular Matrix Structural Constituent Calcium Ion Binding Peptidase Activator Activity
	Biological Process	Cartilage Condensation Ossification Angiogenesis Regulation Of Cell Growth Tissue Homeostasis Positive Regulation Of Protein Phosphorylation Transcription Initiation From RNA Polymerase II Promoter Cell Adhesion Cell-matrix Adhesion Integrin-mediated Signaling Pathway Cell-cell Signaling Positive Regulation Of Cell Proliferation Fibroblast Growth Factor Receptor Signaling Pathway Epidermis Development Response To Wounding Response To Glucose Organ Senescence Gene Expression Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Cell Migration Cell Differentiation Lung Development Regulation Of Chondrocyte Differentiation Response To Estradiol Positive Regulation Of Collagen Biosynthetic Process Response To Anoxia Intracellular Signal Transduction Chondrocyte Proliferation Response To Amino Acid Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Response To Peptide Hormone Cellular Lipid Metabolic Process Small Molecule Metabolic Process Positive Regulation Of Cell Differentiation Positive Regulation Of JNK Cascade Positive Regulation Of Cell Activation Response To Mineralocorticoid Positive Regulation Of Stress Fiber Assembly Cytosolic Calcium Ion Transport Positive Regulation Of Cardiac Muscle Contraction Negative Regulation Of Cell Death Extracellular Matrix Constituent Secretion Positive Regulation Of G0 To G1 Transition Positive Regulation Of ERK1 And ERK2 Cascade Response To Fatty Acid DNA Biosynthetic Process Reactive Oxygen Species Metabolic Process	Embryo Implantation Positive Regulation Of Peptidase Activity Viral Process Extracellular Matrix Organization
Pathways		PPARA activates gene expression Fatty acid, triacylglycerol, and ketone body metabolism Generic Transcription Pathway Metabolism of lipids and lipoproteins YAP1- and WWTR1 (TAZ)-stimulated gene expression Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)	Molecules associated with elastic fibres Elastic fibre formation
Drugs
Diseases
GWAS			Temperament (bipolar disorder) ( 22365631)
Protein-Protein Interactions		11 interactors: ACTB AP3D1 ERBB4 FBLN1 HSPG2 LRP1 NOV TGFB1 TGFB2 TGFB3 VEGFA	35 interactors: ACAN ADAMTSL2 ADAMTSL4 APOA1 APP ATN1 BHLHE40 CACNA1A CTGF ECM1 EDC4 ELN FGB FN1 GFI1B HBEGF HSPG2 ITGB1 LTBP4 MFAP5 MOB4 NEDD1 NID1 NOTCH3 NOV PLSCR1 SKIL SMAD3 SMAD4 TAF9 TANK TCF7L2 TDGF1 VCAN YWHAQ
Entrez ID		1490	2192
HPRD ID		00412	00629
Ensembl ID		ENSG00000118523	ENSG00000077942
Uniprot IDs		P29279 Q5M8T4	P23142 Q8NBH6
PDB IDs
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Macrophage Cytokine Production Salivary Gland Morphogenesis SMAD Protein Import Into Nucleus Salivary Gland Development Exocrine System Development Platelet Activation Platelet Degranulation Gland Development Anatomical Structure Morphogenesis Regulation Of Body Fluid Levels Regulation Of Cell Migration Wound Healing Developmental Process Regulation Of Cell Motility Response To External Stimulus Uterine Wall Breakdown Positive Regulation Of Cell Division Regulation Of Locomotion Positive Regulation Of Protein Transport Regulation Of Cellular Component Movement Response To Wounding Positive Regulation Of Transport Extracellular Matrix Organization Extracellular Structure Organization Regulation Of Immune System Process Positive Regulation Of Epithelial To Mesenchymal Transition Regulation Of Protein Localization Face Morphogenesis Head Development Gland Morphogenesis Positive Regulation Of Cell Morphogenesis Involved In Differentiation Blood Coagulation Hemostasis Mammary Gland Development Vesicle-mediated Transport Head Morphogenesis Positive Regulation Of MAPK Cascade Multicellular Organismal Development Movement Of Cell Or Subcellular Component Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Ossification Involved In Bone Remodeling Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Cell Death Positive Regulation Of Kinase Activity Growth Response To Progesterone Face Development Frontal Suture Morphogenesis Positive Regulation Of Stem Cell Differentiation Regulation Of Pathway-restricted SMAD Protein Phosphorylation	Extracellular Matrix Organization Extracellular Structure Organization Organ Development Regulation Of Cellular Component Organization System Development Multicellular Organismal Development Positive Regulation Of Cell Morphogenesis Involved In Differentiation Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Cellular Response To Growth Factor Stimulus Anatomical Structure Morphogenesis Anatomical Structure Development Positive Regulation Of Cell-substrate Adhesion Developmental Process Regulation Of Growth Regulation Of Cell Differentiation Regulation Of Cell Development Cardiovascular System Development Regulation Of Cell Growth Regulation Of Signaling Tissue Development Regulation Of Signal Transduction Positive Regulation Of Signal Transduction Regulation Of Cell Death Anatomical Structure Formation Involved In Morphogenesis Transcription Initiation From RNA Polymerase II Promoter Nervous System Development Extracellular Matrix Disassembly Regulation Of Cell-substrate Adhesion Regulation Of Cell Morphogenesis Angiogenesis Positive Regulation Of Cell Development Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Cellular Response To Growth Factor Stimulus Response To Wounding Blood Vessel Development Vasculature Development Negative Regulation Of Cell Death Central Nervous System Development Regulation Of Protein Metabolic Process DNA-templated Transcription, Initiation Locomotion Positive Regulation Of Intracellular Signal Transduction Response To Growth Factor Wound Healing Negative Regulation Of Signal Transduction Blood Vessel Morphogenesis Positive Regulation Of Cell Differentiation Ossification Transcription From RNA Polymerase II Promoter Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Tagcloud ?		additively away bsc connective diphosphate edge egr encode fibronectin fn gro hour hsp int message monolayer nak nonwounded osteopontin pa pai plasminogen potentiate quiescent scrape stimulator urokinase wound wounding	3t3 alters anchorage arntl2 bfsp2 bmp7 celsr1 confocal deregulated etv5 exhibits filopodia fmn2 gfra2 gpm6a gpm6b graffi homologs malignancies mulv nih nln oligonucleotide oncogenes parm peri protrusions punctate semi
Tagcloud (Difference) ?		additively away bsc connective diphosphate edge egr encode fibronectin fn gro hour hsp int message monolayer nak nonwounded osteopontin pa pai plasminogen potentiate quiescent scrape stimulator urokinase wound wounding	3t3 alters anchorage arntl2 bfsp2 bmp7 celsr1 confocal deregulated etv5 exhibits filopodia fmn2 gfra2 gpm6a gpm6b graffi homologs malignancies mulv nih nln oligonucleotide oncogenes parm peri protrusions punctate semi
Tagcloud (Intersection) ?