CCN2 and TGFB3

Number of citations of the paper that reports this interaction (PubMedID 10457363)
0

Data Source:
HPRD (in vivo)

		CCN2	TGFB3
Description		cellular communication network factor 2	transforming growth factor beta 3
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Golgi Apparatus Plasma Membrane Extracellular Matrix Cell Periphery	Extracellular Region Extracellular Space Plasma Membrane Extracellular Matrix Platelet Alpha Granule Lumen
	Molecular Function	Integrin Binding Protein Binding Insulin-like Growth Factor Binding Heparin Binding	Type II Transforming Growth Factor Beta Receptor Binding Cytokine Activity Transforming Growth Factor Beta Receptor Binding Protein Binding Growth Factor Activity Type I Transforming Growth Factor Beta Receptor Binding Type III Transforming Growth Factor Beta Receptor Binding Identical Protein Binding Transforming Growth Factor Beta Binding
	Biological Process	Cartilage Condensation Ossification Angiogenesis Osteoblast Differentiation Tissue Homeostasis Chondrocyte Differentiation Cell Adhesion Cell-matrix Adhesion Signal Transduction Integrin-mediated Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Epidermis Development Response To Wounding Negative Regulation Of Gene Expression Cell Migration Lung Development Regulation Of Chondrocyte Differentiation Chondrocyte Proliferation Positive Regulation Of Cell Differentiation Positive Regulation Of JNK Cascade Regulation Of Developmental Process Positive Regulation Of Stress Fiber Assembly Connective Tissue Development Positive Regulation Of ERK1 And ERK2 Cascade DNA Biosynthetic Process Reactive Oxygen Species Metabolic Process	Response To Hypoxia In Utero Embryonic Development Transforming Growth Factor Beta Receptor Signaling Pathway Salivary Gland Morphogenesis Heart Development Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Positive Regulation Of Epithelial To Mesenchymal Transition Negative Regulation Of Macrophage Cytokine Production Mammary Gland Development Response To Progesterone Positive Regulation Of Collagen Biosynthetic Process Regulation Of Cell Population Proliferation Odontogenesis Uterine Wall Breakdown Positive Regulation Of Apoptotic Process Negative Regulation Of Neuron Apoptotic Process Cell-cell Junction Organization Positive Regulation Of Cell Differentiation Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Lung Alveolus Development Positive Regulation Of Protein Secretion Positive Regulation Of Cellular Component Organization Positive Regulation Of Multicellular Organismal Process Positive Regulation Of Filopodium Assembly Positive Regulation Of Stress Fiber Assembly Positive Regulation Of Cell Division Face Morphogenesis Positive Regulation Of SMAD Protein Signal Transduction Secondary Palate Development Detection Of Hypoxia Cellular Response To Growth Factor Stimulus Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Negative Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Regulation Of Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Positive Regulation Of Tight Junction Disassembly
Pathways		YAP1- and WWTR1 (TAZ)-stimulated gene expression RUNX3 regulates YAP1-mediated transcription	Platelet degranulation Molecules associated with elastic fibres TGF-beta receptor signaling activates SMADs ECM proteoglycans
Drugs			1,4-Dioxane
Diseases			Arrhythmogenic right ventricular cardiomyopathy (ARVC) Graft-versus-host disease Isolated orofacial clefts, including: Cleft lip with or without cleft palate; Cleft palate Allograft rejection Ossification of the posterior longitudinal ligament of spine (OPLL)
GWAS			Height ( 33713608)
Interacting Genes		15 interacting genes: ACTB AP3D1 CCN3 ERBB4 FBLN1 HSPG2 LIMS1 LRP1 MMP14 MTDH RSPH1 TGFB1 TGFB2 TGFB3 VEGFA	13 interacting genes: ACVRL1 CCL20 CCN2 CHMP2A ENG FMOD LTBP3 SDC4 TGFB2 TGFBR1 TGFBR2 TGFBR3 VASN
Entrez ID		1490	7043
HPRD ID		00412	01829
Ensembl ID		ENSG00000118523	ENSG00000119699
Uniprot IDs		P29279 Q5M8T4	A5YM40 B3KVH9 P10600
PDB IDs			1KTZ 1TGJ 1TGK 2PJY 3EO1 4UM9 8V52 8VS6 8VSB 9B9F 9FK5
Enriched GO Terms of Interacting Partners?		Extracellular Matrix Regulation Of SMAD Protein Signal Transduction Type III Transforming Growth Factor Beta Receptor Binding Regulation Of Cell Adhesion Positive Regulation Of Multicellular Organismal Process Regulation Of Multicellular Organismal Process Regulation Of Protein Localization Regulation Of Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Positive Regulation Of Developmental Process Cell Surface Receptor Signaling Pathway Type II Transforming Growth Factor Beta Receptor Binding Salivary Gland Morphogenesis Cellular Response To Growth Factor Stimulus Positive Regulation Of Cell Adhesion Response To Hypoxia Negative Regulation Of Macrophage Cytokine Production Regulation Of Cell Population Proliferation Response To Decreased Oxygen Levels Growth Factor Activity Response To Growth Factor Positive Regulation Of Cell Differentiation Response To Oxygen Levels Transforming Growth Factor Beta Receptor Binding Platelet Alpha Granule Lumen Positive Regulation Of Cell Population Proliferation Cell-cell Junction Organization Positive Regulation Of Macromolecule Metabolic Process Regulation Of Developmental Process Regulation Of Epithelial Cell Proliferation Regulation Of Cell Migration Regulation Of Multicellular Organismal Development Enzyme-linked Receptor Protein Signaling Pathway Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Cell Motility Uterine Wall Breakdown Extracellular Space Regulation Of Intracellular Signal Transduction Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Biosynthetic Process Regulation Of Locomotion Positive Regulation Of Cell Division Positive Regulation Of Metabolic Process Regulation Of Extracellular Matrix Disassembly Negative Regulation Of Cell Population Proliferation Positive Regulation Of Protein Localization Cell Junction Organization Gland Morphogenesis Face Morphogenesis Regulation Of Epithelial To Mesenchymal Transition Regulation Of Protein Localization To Plasma Membrane	Transforming Growth Factor Beta Binding Activin Binding Positive Regulation Of SMAD Protein Signal Transduction Positive Regulation Of Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Regulation Of SMAD Protein Signal Transduction Cardiac Epithelial To Mesenchymal Transition Transforming Growth Factor Beta Receptor Activity Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Epithelial To Mesenchymal Transition Positive Regulation Of Cardiac Epithelial To Mesenchymal Transition Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Type II Transforming Growth Factor Beta Receptor Binding Mesenchymal Cell Differentiation Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Artery Morphogenesis Endocardial Cushion Morphogenesis Heart Trabecula Morphogenesis Regulation Of Cartilage Development Cardiac Septum Morphogenesis Enzyme-linked Receptor Protein Signaling Pathway Blood Vessel Morphogenesis Activin Receptor Activity, Type I Regulation Of Epithelial To Mesenchymal Transition Ventricular Septum Morphogenesis Anatomical Structure Formation Involved In Morphogenesis Ventricular Cardiac Muscle Tissue Morphogenesis SMAD Binding Cell Migration Negative Regulation Of Epithelial Cell Proliferation Regulation Of Chondrocyte Differentiation Transmembrane Receptor Protein Serine/threonine Kinase Activity Cardiac Muscle Tissue Morphogenesis Secondary Palate Development Regulation Of Cell Migration Positive Regulation Of Epithelial To Mesenchymal Transition Ventricular Trabecula Myocardium Morphogenesis Cell Surface Regulation Of Cell Motility Cell Motility Regulation Of Locomotion Muscle Tissue Morphogenesis Wound Healing Tissue Morphogenesis Response To Wounding Roof Of Mouth Development Tissue Development Glycosaminoglycan Binding
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