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CCN2 and CCN3
Number of citations of the paper that reports this interaction (PubMedID
9927660
)
37
Data Source:
HPRD
(two hybrid, in vitro)
CCN2
CCN3
Description
cellular communication network factor 2
cellular communication network factor 3
Image
No pdb structure
No pdb structure
GO Annotations
Cellular Component
Extracellular Region
Extracellular Space
Golgi Apparatus
Plasma Membrane
Extracellular Matrix
Cell Periphery
Extracellular Region
Extracellular Space
Cytoplasm
Cytosol
Gap Junction
Extracellular Matrix
Anchoring Junction
Molecular Function
Integrin Binding
Protein Binding
Insulin-like Growth Factor Binding
Heparin Binding
Signaling Receptor Binding
Notch Binding
Integrin Binding
Hormone Activity
Protein Binding
Growth Factor Activity
Heparin Binding
Biological Process
Cartilage Condensation
Ossification
Angiogenesis
Osteoblast Differentiation
Tissue Homeostasis
Chondrocyte Differentiation
Cell Adhesion
Cell-matrix Adhesion
Signal Transduction
Integrin-mediated Signaling Pathway
Fibroblast Growth Factor Receptor Signaling Pathway
Epidermis Development
Response To Wounding
Negative Regulation Of Gene Expression
Cell Migration
Lung Development
Regulation Of Chondrocyte Differentiation
Chondrocyte Proliferation
Positive Regulation Of Cell Differentiation
Positive Regulation Of JNK Cascade
Regulation Of Developmental Process
Positive Regulation Of Stress Fiber Assembly
Connective Tissue Development
Positive Regulation Of ERK1 And ERK2 Cascade
DNA Biosynthetic Process
Reactive Oxygen Species Metabolic Process
Angiogenesis
Chondrocyte Differentiation
Cell Adhesion
Signal Transduction
Fibroblast Migration
Negative Regulation Of Myotube Differentiation
Smooth Muscle Cell Migration
Negative Regulation Of Cell Growth
Cell Adhesion Mediated By Integrin
Endothelial Cell Chemotaxis
Type B Pancreatic Cell Proliferation
Positive Regulation Of Cell Differentiation
Positive Regulation Of Notch Signaling Pathway
Positive Regulation Of Ossification
Negative Regulation Of Insulin Secretion
Smooth Muscle Cell Proliferation
Negative Regulation Of Inflammatory Response
Regulation Of Developmental Process
Cell Chemotaxis
Negative Regulation Of SMAD Protein Signal Transduction
Hematopoietic Stem Cell Homeostasis
Endothelial Cell-cell Adhesion
Negative Regulation Of Monocyte Chemotaxis
Negative Regulation Of Non-canonical NF-kappaB Signal Transduction
Negative Regulation Of Chondrocyte Proliferation
Negative Regulation Of Sensory Perception Of Pain
Bone Regeneration
Pathways
YAP1- and WWTR1 (TAZ)-stimulated gene expression
RUNX3 regulates YAP1-mediated transcription
Drugs
Insulin human
Diseases
GWAS
Interacting Genes
15 interacting genes:
ACTB
AP3D1
CCN3
ERBB4
FBLN1
HSPG2
LIMS1
LRP1
MMP14
MTDH
RSPH1
TGFB1
TGFB2
TGFB3
VEGFA
31 interacting genes:
ADSL
ANKRD11
APOL6
C11orf87
CCN2
CDKN1A
COL8A1
DLL1
FAM90A1
FBLN1
FN1
FRS3
FXR1
FXR2
GJA1
HOXA1
IGF1
IGF2
INS
ITGAV
KRTAP5-6
LCE1A
LCE3D
NID2
NOTCH1
POLR2L
POU4F2
RECK
S100A4
TNIP3
ZNF330
Entrez ID
1490
4856
HPRD ID
00412
01291
Ensembl ID
ENSG00000118523
ENSG00000136999
Uniprot IDs
P29279
Q5M8T4
P48745
PDB IDs
Enriched GO Terms of Interacting Partners
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Extracellular Matrix
Regulation Of SMAD Protein Signal Transduction
Type III Transforming Growth Factor Beta Receptor Binding
Regulation Of Cell Adhesion
Positive Regulation Of Multicellular Organismal Process
Regulation Of Multicellular Organismal Process
Regulation Of Protein Localization
Regulation Of Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation
Positive Regulation Of Developmental Process
Cell Surface Receptor Signaling Pathway
Type II Transforming Growth Factor Beta Receptor Binding
Salivary Gland Morphogenesis
Cellular Response To Growth Factor Stimulus
Positive Regulation Of Cell Adhesion
Response To Hypoxia
Negative Regulation Of Macrophage Cytokine Production
Regulation Of Cell Population Proliferation
Response To Decreased Oxygen Levels
Growth Factor Activity
Response To Growth Factor
Positive Regulation Of Cell Differentiation
Response To Oxygen Levels
Transforming Growth Factor Beta Receptor Binding
Platelet Alpha Granule Lumen
Positive Regulation Of Cell Population Proliferation
Cell-cell Junction Organization
Positive Regulation Of Macromolecule Metabolic Process
Regulation Of Developmental Process
Regulation Of Epithelial Cell Proliferation
Regulation Of Cell Migration
Regulation Of Multicellular Organismal Development
Enzyme-linked Receptor Protein Signaling Pathway
Positive Regulation Of Macromolecule Biosynthetic Process
Regulation Of Cell Motility
Uterine Wall Breakdown
Extracellular Space
Regulation Of Intracellular Signal Transduction
Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Positive Regulation Of Biosynthetic Process
Regulation Of Locomotion
Positive Regulation Of Cell Division
Positive Regulation Of Metabolic Process
Regulation Of Extracellular Matrix Disassembly
Negative Regulation Of Cell Population Proliferation
Positive Regulation Of Protein Localization
Cell Junction Organization
Gland Morphogenesis
Face Morphogenesis
Regulation Of Epithelial To Mesenchymal Transition
Regulation Of Protein Localization To Plasma Membrane
Tissue Development
Epidermis Development
Integrin Binding
Positive Regulation Of Growth
Positive Regulation Of Developmental Growth
Regulation Of Growth
Regulation Of Developmental Growth
Regulation Of Cell Differentiation
Positive Regulation Of Cell Population Proliferation
Positive Regulation Of Fibroblast Proliferation
Receptor Ligand Activity
Insulin-like Growth Factor Receptor Binding
Positive Regulation Of Glycogen Biosynthetic Process
Wound Healing
Positive Regulation Of Signal Transduction
Positive Regulation Of Substrate-dependent Cell Migration, Cell Attachment To Substrate
Regulation Of Cell Development
Regulation Of Nervous System Development
Insulin Receptor Binding
Positive Regulation Of Small GTPase Mediated Signal Transduction
Regulation Of Translation At Presynapse, Modulating Synaptic Transmission
Positive Regulation Of Developmental Process
Regulation Of Multicellular Organismal Process
Negative Regulation Of Gene Expression
Angiogenesis
Positive Regulation Of Cell Differentiation
Alphav-beta3 Integrin-IGF-1-IGF1R Complex
Negative Regulation Of Inner Ear Auditory Receptor Cell Differentiation
Negative Regulation Of Inner Ear Receptor Cell Differentiation
Compartment Pattern Specification
Positive Regulation Of Intracellular Signal Transduction
Regulation Of Fibroblast Proliferation
Regulation Of Glycogen Biosynthetic Process
Basement Membrane
Negative Regulation Of Multicellular Organismal Process
Regulation Of Developmental Process
Response To Wounding
Extracellular Region
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Integrin-mediated Signaling Pathway
Positive Regulation Of Skeletal Muscle Tissue Growth
Endodermal Cell Differentiation
Positive Regulation Of D-glucose Import
Cell-matrix Adhesion
Regulation Of Neurogenesis
Regulation Of Glycogen Metabolic Process
Regulation Of Somitogenesis
Positive Regulation Of Neurogenesis
Regulation Of Skeletal Muscle Tissue Growth
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Tagcloud (Intersection)
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