CCN2

Description		cellular communication network factor 2
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Golgi Apparatus Plasma Membrane Extracellular Matrix Cell Periphery
	Molecular Function	Integrin Binding Protein Binding Insulin-like Growth Factor Binding Heparin Binding
	Biological Process	Cartilage Condensation Ossification Angiogenesis Osteoblast Differentiation Tissue Homeostasis Chondrocyte Differentiation Cell Adhesion Cell-matrix Adhesion Signal Transduction Integrin-mediated Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Epidermis Development Response To Wounding Negative Regulation Of Gene Expression Cell Migration Lung Development Regulation Of Chondrocyte Differentiation Chondrocyte Proliferation Positive Regulation Of Cell Differentiation Positive Regulation Of JNK Cascade Regulation Of Developmental Process Positive Regulation Of Stress Fiber Assembly Connective Tissue Development Positive Regulation Of ERK1 And ERK2 Cascade DNA Biosynthetic Process Reactive Oxygen Species Metabolic Process
Pathways		YAP1- and WWTR1 (TAZ)-stimulated gene expression RUNX3 regulates YAP1-mediated transcription
Drugs
Diseases
GWAS
Interacting Genes		15 interacting genes: ACTB AP3D1 CCN3 ERBB4 FBLN1 HSPG2 LIMS1 LRP1 MMP14 MTDH RSPH1 TGFB1 TGFB2 TGFB3 VEGFA
Entrez ID		1490
HPRD ID		00412
Ensembl ID		ENSG00000118523
Uniprot IDs		P29279 Q5M8T4
PDB IDs
Enriched GO Terms of Interacting Partners?		Extracellular Matrix Regulation Of SMAD Protein Signal Transduction Type III Transforming Growth Factor Beta Receptor Binding Regulation Of Cell Adhesion Positive Regulation Of Multicellular Organismal Process Regulation Of Multicellular Organismal Process Regulation Of Protein Localization Regulation Of Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Positive Regulation Of Developmental Process Cell Surface Receptor Signaling Pathway Type II Transforming Growth Factor Beta Receptor Binding Salivary Gland Morphogenesis Cellular Response To Growth Factor Stimulus Positive Regulation Of Cell Adhesion Response To Hypoxia Negative Regulation Of Macrophage Cytokine Production Regulation Of Cell Population Proliferation Response To Decreased Oxygen Levels Growth Factor Activity Response To Growth Factor Positive Regulation Of Cell Differentiation Response To Oxygen Levels Transforming Growth Factor Beta Receptor Binding Platelet Alpha Granule Lumen Positive Regulation Of Cell Population Proliferation Cell-cell Junction Organization Positive Regulation Of Macromolecule Metabolic Process Regulation Of Developmental Process Regulation Of Epithelial Cell Proliferation Regulation Of Cell Migration Regulation Of Multicellular Organismal Development Enzyme-linked Receptor Protein Signaling Pathway Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Cell Motility Uterine Wall Breakdown Extracellular Space Regulation Of Intracellular Signal Transduction Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Biosynthetic Process Regulation Of Locomotion Positive Regulation Of Cell Division Positive Regulation Of Metabolic Process Regulation Of Extracellular Matrix Disassembly Negative Regulation Of Cell Population Proliferation Positive Regulation Of Protein Localization Cell Junction Organization Gland Morphogenesis Face Morphogenesis Regulation Of Epithelial To Mesenchymal Transition Regulation Of Protein Localization To Plasma Membrane
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