CTGF and VEGFA

Number of citations of the paper that reports this interaction (PMID 11744618)
79

Data Source:
HPRD (in vivo, two hybrid)

		CTGF	VEGFA
Gene Name		connective tissue growth factor	vascular endothelial growth factor A
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Proteinaceous Extracellular Matrix Extracellular Space Golgi Apparatus Cis-Golgi Network Cytosol Plasma Membrane Cell Cortex Intracellular Membrane-bounded Organelle Perinuclear Region Of Cytoplasm	Extracellular Region Proteinaceous Extracellular Matrix Extracellular Space Cytoplasm Cell Surface Membrane Secretory Granule Platelet Alpha Granule Lumen
	Molecular Function	Fibronectin Binding Integrin Binding Protein Binding Insulin-like Growth Factor Binding Growth Factor Activity Heparin Binding	Fibronectin Binding Cytokine Activity Platelet-derived Growth Factor Receptor Binding Vascular Endothelial Growth Factor Receptor Binding Protein Binding Growth Factor Activity Heparin Binding Neuropilin Binding Chemoattractant Activity Identical Protein Binding Protein Homodimerization Activity Vascular Endothelial Growth Factor Receptor 1 Binding Vascular Endothelial Growth Factor Receptor 2 Binding Protein Heterodimerization Activity Receptor Agonist Activity Extracellular Matrix Binding
	Biological Process	Cartilage Condensation Ossification Angiogenesis Regulation Of Cell Growth Tissue Homeostasis Positive Regulation Of Protein Phosphorylation Transcription Initiation From RNA Polymerase II Promoter Cell Adhesion Cell-matrix Adhesion Integrin-mediated Signaling Pathway Cell-cell Signaling Positive Regulation Of Cell Proliferation Fibroblast Growth Factor Receptor Signaling Pathway Epidermis Development Response To Wounding Response To Glucose Organ Senescence Gene Expression Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Cell Migration Cell Differentiation Lung Development Regulation Of Chondrocyte Differentiation Response To Estradiol Positive Regulation Of Collagen Biosynthetic Process Response To Anoxia Intracellular Signal Transduction Chondrocyte Proliferation Response To Amino Acid Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Response To Peptide Hormone Cellular Lipid Metabolic Process Small Molecule Metabolic Process Positive Regulation Of Cell Differentiation Positive Regulation Of JNK Cascade Positive Regulation Of Cell Activation Response To Mineralocorticoid Positive Regulation Of Stress Fiber Assembly Cytosolic Calcium Ion Transport Positive Regulation Of Cardiac Muscle Contraction Negative Regulation Of Cell Death Extracellular Matrix Constituent Secretion Positive Regulation Of G0 To G1 Transition Positive Regulation Of ERK1 And ERK2 Cascade Response To Fatty Acid DNA Biosynthetic Process Reactive Oxygen Species Metabolic Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Angiogenesis Ovarian Follicle Development Patterning Of Blood Vessels Vasculogenesis Response To Hypoxia In Utero Embryonic Development Kidney Development Positive Regulation Of Protein Phosphorylation Positive Regulation Of Endothelial Cell Proliferation Cell Migration Involved In Sprouting Angiogenesis Positive Regulation Of Neuroblast Proliferation Positive Regulation Of Mesenchymal Cell Proliferation Positive Regulation Of Receptor Internalization Basophil Chemotaxis Platelet Degranulation Positive Regulation Of Leukocyte Migration Heart Morphogenesis Outflow Tract Morphogenesis Coronary Vein Morphogenesis Regulation Of Transcription From RNA Polymerase II Promoter Nervous System Development Mesoderm Development Lactation Blood Coagulation Positive Regulation Of Cell Proliferation Regulation Of Cell Shape Positive Regulation Of Endothelial Cell Migration Positive Regulation Of Gene Expression Platelet Activation Monocyte Differentiation Macrophage Differentiation Lung Development Positive Regulation Of Cell Migration Regulation Of CGMP Metabolic Process Epithelial Cell Differentiation Positive Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Post-embryonic Camera-type Eye Development Positive Regulation Of Protein Complex Assembly Positive Regulation Of Protein Autophosphorylation Activation Of Protein Kinase Activity Positive Regulation Of CREB Transcription Factor Activity Positive Regulation Of Peptidyl-serine Phosphorylation Tube Formation Endothelial Cell Chemotaxis Cellular Response To Vascular Endothelial Growth Factor Stimulus Lymph Vessel Morphogenesis Positive Regulation Of Endothelial Cell Chemotaxis By VEGF-activated Vascular Endothelial Growth Factor Receptor Signaling Pathway Vascular Endothelial Growth Factor Signaling Pathway Positive Regulation Of Cell Proliferation By VEGF-activated Platelet Derived Growth Factor Receptor Signaling Pathway VEGF-activated Neuropilin Signaling Pathway Growth Eye Photoreceptor Cell Development Negative Regulation Of Apoptotic Process Positive Regulation Of Vascular Permeability Surfactant Homeostasis Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of MAP Kinase Activity Positive Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of Angiogenesis Positive Regulation Of Cell Adhesion Positive Regulation Of Transcription From RNA Polymerase II Promoter Vascular Endothelial Growth Factor Receptor Signaling Pathway Cell Maturation Camera-type Eye Morphogenesis Cardiac Muscle Fiber Development Branching Morphogenesis Of An Epithelial Tube Positive Regulation Of Axon Extension Involved In Axon Guidance Artery Morphogenesis Positive Regulation Of Epithelial Cell Proliferation Positive Regulation Of Peptidyl-tyrosine Phosphorylation Positive Chemotaxis Positive Regulation Of Positive Chemotaxis Induction Of Positive Chemotaxis Positive Regulation Of Cellular Component Movement Positive Regulation Of Cell Division Positive Regulation Of Focal Adhesion Assembly Primitive Erythrocyte Differentiation Mammary Gland Alveolus Development Positive Regulation Of Mast Cell Chemotaxis Cardiac Vascular Smooth Muscle Cell Development Coronary Artery Morphogenesis Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Hypoxia Dopaminergic Neuron Differentiation Commissural Neuron Axon Guidance Positive Regulation Of Protein Kinase C Signaling Positive Regulation Of Cell Migration Involved In Sprouting Angiogenesis Positive Regulation Of Branching Involved In Ureteric Bud Morphogenesis Regulation Of Retinal Ganglion Cell Axon Guidance Positive Regulation Of Peptidyl-tyrosine Autophosphorylation Positive Regulation Of P38MAPK Cascade Positive Regulation Of Histone Deacetylase Activity Positive Regulation Of Retinal Ganglion Cell Axon Guidance Positive Regulation Of Protein Localization To Early Endosome Positive Regulation Of Protein Kinase D Signaling
Pathways		PPARA activates gene expression Fatty acid, triacylglycerol, and ketone body metabolism Generic Transcription Pathway Metabolism of lipids and lipoproteins YAP1- and WWTR1 (TAZ)-stimulated gene expression Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)	VEGF binds to VEGFR leading to receptor dimerization Cellular response to hypoxia VEGF ligand-receptor interactions Regulation of Hypoxia-inducible Factor (HIF) by oxygen Signaling by VEGF Response to elevated platelet cytosolic Ca2+ Platelet degranulation Platelet activation, signaling and aggregation Regulation of gene expression by Hypoxia-inducible Factor
Drugs			Bevacizumab Minocycline Gliclazide Carvedilol Ranibizumab Pyroglutamic Acid Tris(Hydroxymethyl)Aminomethane Vandetanib Dalteparin Aflibercept
Diseases
GWAS			Adiponectin levels ( 22479202) Age-related macular degeneration ( 23455636 21665990) Chronic kidney disease ( 20383146) Coronary heart disease ( 22319020) Thyroid hormone levels ( 23408906) Type 2 diabetes ( 18372903) Urate levels ( 23263486) Waist-hip ratio ( 20935629)
Protein-Protein Interactions		11 interactors: ACTB AP3D1 ERBB4 FBLN1 HSPG2 LRP1 NOV TGFB1 TGFB2 TGFB3 VEGFA	25 interactors: ADAMTS1 AKT1 CRYAB CTGF ELAVL1 EPHB2 FLT1 GPC1 HNRNPD IGFBP7 KDR LYVE1 NRP1 NRP2 PGF PRRG4 SEMA3F SPARC TNXB U2AF1 VEGFB VPS35 VTN YBX1 YBX3
Entrez ID		1490	7422
HPRD ID		00412	01889
Ensembl ID		ENSG00000118523	ENSG00000112715
Uniprot IDs		P29279 Q5M8T4	A2A2V4 P15692
PDB IDs			1BJ1 1CZ8 1FLT 1KAT 1KMX 1MJV 1MKG 1MKK 1QTY 1TZH 1TZI 1VGH 1VPF 1VPP 2FJG 2FJH 2QR0 2VGH 2VPF 3BDY 3P9W 3QTK 3S1B 3S1K 3V2A 4DEQ 4GLN 4GLS
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Macrophage Cytokine Production Salivary Gland Morphogenesis SMAD Protein Import Into Nucleus Salivary Gland Development Exocrine System Development Platelet Activation Platelet Degranulation Gland Development Anatomical Structure Morphogenesis Regulation Of Body Fluid Levels Regulation Of Cell Migration Wound Healing Developmental Process Regulation Of Cell Motility Response To External Stimulus Uterine Wall Breakdown Positive Regulation Of Cell Division Regulation Of Locomotion Positive Regulation Of Protein Transport Regulation Of Cellular Component Movement Response To Wounding Positive Regulation Of Transport Extracellular Matrix Organization Extracellular Structure Organization Regulation Of Immune System Process Positive Regulation Of Epithelial To Mesenchymal Transition Regulation Of Protein Localization Face Morphogenesis Head Development Gland Morphogenesis Positive Regulation Of Cell Morphogenesis Involved In Differentiation Blood Coagulation Hemostasis Mammary Gland Development Vesicle-mediated Transport Head Morphogenesis Positive Regulation Of MAPK Cascade Multicellular Organismal Development Movement Of Cell Or Subcellular Component Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Ossification Involved In Bone Remodeling Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Cell Death Positive Regulation Of Kinase Activity Growth Response To Progesterone Face Development Frontal Suture Morphogenesis Positive Regulation Of Stem Cell Differentiation Regulation Of Pathway-restricted SMAD Protein Phosphorylation	Regulation Of Endothelial Cell Proliferation Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Regulation Of Endothelial Cell Proliferation Cardiovascular System Development Angiogenesis Positive Regulation Of Cell Migration Blood Vessel Development Positive Regulation Of Cell Motility Vascular Endothelial Growth Factor Signaling Pathway Positive Regulation Of Cellular Component Movement Vasculature Development Positive Regulation Of Locomotion Multicellular Organismal Development Anatomical Structure Formation Involved In Morphogenesis Developmental Process Positive Regulation Of Endothelial Cell Migration Anatomical Structure Development Blood Vessel Morphogenesis Positive Regulation Of Epithelial Cell Proliferation Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Epithelial Cell Proliferation Regulation Of Locomotion Anatomical Structure Morphogenesis Sympathetic Neuron Projection Extension Sympathetic Neuron Projection Guidance Ventral Trunk Neural Crest Cell Migration Regulation Of Cellular Component Movement Positive Regulation Of Epithelial Cell Migration Cellular Response To Vascular Endothelial Growth Factor Stimulus Neural Crest Cell Migration Involved In Autonomic Nervous System Development Semaphorin-plexin Signaling Pathway Involved In Neuron Projection Guidance Axon Extension Involved In Axon Guidance Regulation Of Endothelial Cell Migration Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Cell Proliferation Regulation Of Cell Migration Embryo Development Sympathetic Ganglion Development Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Cell Motility Facial Nerve Structural Organization Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Facial Nerve Morphogenesis Organ Development Regulation Of MRNA Stability System Development Cranial Nerve Development Regulation Of RNA Stability Sprouting Angiogenesis
Tagcloud ?		additively away bsc connective diphosphate edge egr encode fibronectin fn gro hour hsp int message monolayer nak nonwounded osteopontin pa pai plasminogen potentiate quiescent scrape stimulator urokinase wound wounding	autophagy bcl2 birc5 buffer constituents damaged dataset degrades deregulation distant eif4ebp1 ero1l fos gapdh gse21653 gse3494 gse7390 inc itpr1 lived organelles periodicals prognostic proportional shortened signature starvation subgroups wiley
Tagcloud (Difference) ?		additively away bsc connective diphosphate edge egr encode fibronectin fn gro hour hsp int message monolayer nak nonwounded osteopontin pa pai plasminogen potentiate quiescent scrape stimulator urokinase wound wounding	autophagy bcl2 birc5 buffer constituents damaged dataset degrades deregulation distant eif4ebp1 ero1l fos gapdh gse21653 gse3494 gse7390 inc itpr1 lived organelles periodicals prognostic proportional shortened signature starvation subgroups wiley
Tagcloud (Intersection) ?