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CCN2 and TGFB2
Number of citations of the paper that reports this interaction (PubMedID
10457363
)
0
Data Source:
HPRD
(in vivo)
CCN2
TGFB2
Description
cellular communication network factor 2
transforming growth factor beta 2
Image
No pdb structure
GO Annotations
Cellular Component
Extracellular Region
Extracellular Space
Golgi Apparatus
Plasma Membrane
Extracellular Matrix
Cell Periphery
Extracellular Region
Extracellular Space
Endosome
Axon
Extracellular Matrix
Platelet Alpha Granule Lumen
Neuronal Cell Body
Molecular Function
Integrin Binding
Protein Binding
Insulin-like Growth Factor Binding
Heparin Binding
Amyloid-beta Binding
Signaling Receptor Binding
Type II Transforming Growth Factor Beta Receptor Binding
Cytokine Activity
Transforming Growth Factor Beta Receptor Binding
Protein Binding
Growth Factor Activity
Type III Transforming Growth Factor Beta Receptor Binding
Protein Homodimerization Activity
Biological Process
Cartilage Condensation
Ossification
Angiogenesis
Osteoblast Differentiation
Tissue Homeostasis
Chondrocyte Differentiation
Cell Adhesion
Cell-matrix Adhesion
Signal Transduction
Integrin-mediated Signaling Pathway
Fibroblast Growth Factor Receptor Signaling Pathway
Epidermis Development
Response To Wounding
Negative Regulation Of Gene Expression
Cell Migration
Lung Development
Regulation Of Chondrocyte Differentiation
Chondrocyte Proliferation
Positive Regulation Of Cell Differentiation
Positive Regulation Of JNK Cascade
Regulation Of Developmental Process
Positive Regulation Of Stress Fiber Assembly
Connective Tissue Development
Positive Regulation Of ERK1 And ERK2 Cascade
DNA Biosynthetic Process
Reactive Oxygen Species Metabolic Process
Cell Morphogenesis
Skeletal System Development
Cartilage Condensation
Blood Vessel Development
Eye Development
Response To Hypoxia
Kidney Development
Epithelial To Mesenchymal Transition
Neural Tube Closure
Hair Follicle Development
Blood Vessel Remodeling
Heart Morphogenesis
Outflow Tract Septum Morphogenesis
Membranous Septum Morphogenesis
Outflow Tract Morphogenesis
Heart Valve Morphogenesis
Atrioventricular Valve Morphogenesis
Pulmonary Valve Morphogenesis
Endocardial Cushion Morphogenesis
Cardiac Right Ventricle Morphogenesis
Ventricular Trabecula Myocardium Morphogenesis
Endocardial Cushion Fusion
Atrial Septum Primum Morphogenesis
Neural Retina Development
Activation-induced Cell Death Of T Cells
Transforming Growth Factor Beta Receptor Signaling Pathway
Axon Guidance
Sensory Organ Development
Salivary Gland Morphogenesis
Heart Development
Positive Regulation Of Cell Population Proliferation
Negative Regulation Of Cell Population Proliferation
Glial Cell Migration
Male Gonad Development
Response To Wounding
Embryo Development Ending In Birth Or Egg Hatching
Cardioblast Differentiation
Positive Regulation Of Gene Expression
Negative Regulation Of Gene Expression
Positive Regulation Of Epithelial Cell Migration
Positive Regulation Of Epithelial To Mesenchymal Transition
Negative Regulation Of Macrophage Cytokine Production
Striated Muscle Tissue Development
Cell Migration
Negative Regulation Of Angiogenesis
Signaling
Hemopoiesis
Extracellular Matrix Organization
Collagen Fibril Organization
Positive Regulation Of Cell Growth
Negative Regulation Of Cell Growth
Embryonic Limb Morphogenesis
Neutrophil Chemotaxis
Epithelial Cell Differentiation
Hair Follicle Morphogenesis
Response To Progesterone
Positive Regulation Of Stress-activated MAPK Cascade
Regulation Of Transforming Growth Factor Beta2 Production
Regulation Of Actin Cytoskeleton Organization
Positive Regulation Of Cell Adhesion Mediated By Integrin
Ascending Aorta Morphogenesis
Wound Healing
Regulation Of Cell Population Proliferation
Dopamine Biosynthetic Process
Odontogenesis
Uterine Wall Breakdown
Regulation Of Apoptotic Process
Positive Regulation Of Apoptotic Process
Positive Regulation Of Neuron Apoptotic Process
Cell-cell Junction Organization
Positive Regulation Of Cell Differentiation
Positive Regulation Of Integrin Biosynthetic Process
Positive Regulation Of Notch Signaling Pathway
Positive Regulation Of Cell Cycle
Positive Regulation Of Heart Contraction
Negative Regulation Of Ras Protein Signal Transduction
Somatic Stem Cell Division
Embryonic Digestive Tract Development
Neuron Fate Commitment
Neuron Development
Generation Of Neurons
Inner Ear Development
Negative Regulation Of Epithelial Cell Proliferation
Positive Regulation Of Protein Secretion
Positive Regulation Of Immune Response
Positive Regulation Of Cellular Component Organization
Positive Regulation Of Multicellular Organismal Process
Positive Regulation Of Cell Division
Regulation Of Timing Of Catagen
Positive Regulation Of Timing Of Catagen
Positive Regulation Of Cardioblast Differentiation
Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Cardiac Muscle Cell Proliferation
Uterus Development
Cardiac Epithelial To Mesenchymal Transition
Face Morphogenesis
Positive Regulation Of SMAD Protein Signal Transduction
Ventricular Septum Morphogenesis
Atrial Septum Morphogenesis
Negative Regulation Of Cartilage Development
Pharyngeal Arch Artery Morphogenesis
Secondary Palate Development
Positive Regulation Of Cardiac Epithelial To Mesenchymal Transition
Positive Regulation Of Activation-induced Cell Death Of T Cells
Cellular Response To Growth Factor Stimulus
Positive Regulation Of Extracellular Matrix Disassembly
Extrinsic Apoptotic Signaling Pathway
Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway
Positive Regulation Of Protein Localization To Nucleus
Regulation Of Apoptotic Process Involved In Outflow Tract Morphogenesis
Positive Regulation Of MiRNA Transcription
Regulation Of Extracellular Matrix Organization
Regulation Of Complement-dependent Cytotoxicity
Substantia Propria Of Cornea Development
Pericyte Cell Differentiation
Cranial Skeletal System Development
Negative Regulation Of Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation
Positive Regulation Of Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation
Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Pathways
YAP1- and WWTR1 (TAZ)-stimulated gene expression
RUNX3 regulates YAP1-mediated transcription
Platelet degranulation
Molecules associated with elastic fibres
TGF-beta receptor signaling activates SMADs
ECM proteoglycans
TGFBR3 regulates TGF-beta signaling
Drugs
Trabedersen
Diseases
Graft-versus-host disease
Allograft rejection
GWAS
Acne (severe) (
24927181
30542056
)
Appendicular lean mass (
33097823
)
Body fat distribution (leg fat ratio) (
30664634
)
Body fat distribution (trunk fat ratio) (
30664634
)
Bone mineral density (hip) (
30172743
)
Central corneal thickness (
29760442
32528159
)
Chronic obstructive pulmonary disease (
30804561
28166215
)
Chronic obstructive pulmonary disease (severe) (
24621683
)
Diastolic blood pressure (
30224653
)
Diffusing capacity of carbon monoxide (
30694715
)
Emphysema imaging phenotypes (
26030696
)
FEV1 (
30804560
)
Gemcitabine-induced early high-grade neutropenia in pancreatic cancer (
30889042
)
Heel bone mineral density (
30598549
)
Height (
31562340
20881960
25429064
25282103
)
Hip circumference adjusted for BMI (
34021172
25673412
)
Hip minimal joint space width (
27701424
)
Intraocular pressure (
29617998
)
Local histogram emphysema pattern (
25006744
)
Lung function (FEV1/FVC) (
30804560
)
Lung function (FVC) (
30804560
)
Peak expiratory flow (
30804560
)
Post bronchodilator FEV1 (
26634245
)
Post bronchodilator FEV1/FVC ratio (
26634245
)
Pulmonary function (
21946350
)
Refractive error (
32231278
)
Rosacea symptom severity (
29771307
)
Systolic blood pressure (
30578418
)
Vertical cup-disc ratio (adjusted for vertical disc diameter) (
31959993
)
Vertical cup-disc ratio (multi-trait analysis) (
31959993
)
Waist circumference adjusted for BMI (adjusted for smoking behaviour) (
28443625
)
Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) (
28448500
)
Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) (
28443625
)
Waist circumference adjusted for BMI in active individuals (
28448500
)
Waist circumference adjusted for BMI in non-smokers (
28443625
)
Waist circumference adjusted for body mass index (
28448500
25673412
34021172
)
Interacting Genes
15 interacting genes:
ACTB
AP3D1
CCN3
ERBB4
FBLN1
HSPG2
LIMS1
LRP1
MMP14
MTDH
RSPH1
TGFB1
TGFB2
TGFB3
VEGFA
16 interacting genes:
APP
BMP2
CCN2
DCN
ENG
FMOD
LTBP3
PZP
SNCA
TGFB1
TGFB3
TGFBR1
TGFBR2
TGFBR3
VASN
VTN
Entrez ID
1490
7042
HPRD ID
00412
01828
Ensembl ID
ENSG00000118523
ENSG00000092969
Uniprot IDs
P29279
Q5M8T4
P61812
Q59EG9
PDB IDs
1TFG
2TGI
4KXZ
5TX4
5TY4
6I9J
6XM2
7RCO
8DC0
8FXS
8FXV
Enriched GO Terms of Interacting Partners
?
Extracellular Matrix
Regulation Of SMAD Protein Signal Transduction
Type III Transforming Growth Factor Beta Receptor Binding
Regulation Of Cell Adhesion
Positive Regulation Of Multicellular Organismal Process
Regulation Of Multicellular Organismal Process
Regulation Of Protein Localization
Regulation Of Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation
Positive Regulation Of Developmental Process
Cell Surface Receptor Signaling Pathway
Type II Transforming Growth Factor Beta Receptor Binding
Salivary Gland Morphogenesis
Cellular Response To Growth Factor Stimulus
Positive Regulation Of Cell Adhesion
Response To Hypoxia
Negative Regulation Of Macrophage Cytokine Production
Regulation Of Cell Population Proliferation
Response To Decreased Oxygen Levels
Growth Factor Activity
Response To Growth Factor
Positive Regulation Of Cell Differentiation
Response To Oxygen Levels
Transforming Growth Factor Beta Receptor Binding
Platelet Alpha Granule Lumen
Positive Regulation Of Cell Population Proliferation
Cell-cell Junction Organization
Positive Regulation Of Macromolecule Metabolic Process
Regulation Of Developmental Process
Regulation Of Epithelial Cell Proliferation
Regulation Of Cell Migration
Regulation Of Multicellular Organismal Development
Enzyme-linked Receptor Protein Signaling Pathway
Positive Regulation Of Macromolecule Biosynthetic Process
Regulation Of Cell Motility
Uterine Wall Breakdown
Extracellular Space
Regulation Of Intracellular Signal Transduction
Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Positive Regulation Of Biosynthetic Process
Regulation Of Locomotion
Positive Regulation Of Cell Division
Positive Regulation Of Metabolic Process
Regulation Of Extracellular Matrix Disassembly
Negative Regulation Of Cell Population Proliferation
Positive Regulation Of Protein Localization
Cell Junction Organization
Gland Morphogenesis
Face Morphogenesis
Regulation Of Epithelial To Mesenchymal Transition
Regulation Of Protein Localization To Plasma Membrane
Transforming Growth Factor Beta Binding
Regulation Of Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation
Positive Regulation Of SMAD Protein Signal Transduction
Regulation Of Epithelial To Mesenchymal Transition
Type II Transforming Growth Factor Beta Receptor Binding
Regulation Of SMAD Protein Signal Transduction
Extracellular Space
Cellular Response To Growth Factor Stimulus
Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway
Transforming Growth Factor Beta Receptor Signaling Pathway
Response To Growth Factor
Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway
Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway
Positive Regulation Of Epithelial To Mesenchymal Transition
Epithelial To Mesenchymal Transition
Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway
Activin Binding
Type I Transforming Growth Factor Beta Receptor Binding
Extracellular Region
Mesenchymal Cell Differentiation
Regulation Of Multicellular Organismal Process
Cardiac Muscle Tissue Morphogenesis
Positive Regulation Of Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation
Type III Transforming Growth Factor Beta Receptor Binding
Extracellular Matrix
Enzyme-linked Receptor Protein Signaling Pathway
Glycosaminoglycan Binding
Regulation Of Cartilage Development
Positive Regulation Of Developmental Process
Muscle Tissue Morphogenesis
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Cardiac Epithelial To Mesenchymal Transition
Regulation Of Locomotion
Animal Organ Morphogenesis
Positive Regulation Of Mesenchymal Stem Cell Proliferation
Regulation Of Developmental Process
Positive Regulation Of Intracellular Signal Transduction
Regulation Of Cell Differentiation
Golgi Lumen
Negative Regulation Of Multicellular Organismal Process
Cell Surface Receptor Signaling Pathway
Transforming Growth Factor Beta Receptor Activity
Positive Regulation Of Cell Differentiation
Positive Regulation Of Signal Transduction
Positive Regulation Of Cardiac Epithelial To Mesenchymal Transition
Cell Surface
Ventricular Cardiac Muscle Tissue Morphogenesis
Extracellular Matrix Organization
Extracellular Structure Organization
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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