PNN and KRT8

Number of citations of the paper that reports this interaction (PMID 10809736)
6

Data Source:
HPRD (in vitro, two hybrid)

		PNN	KRT8
Gene Name		pinin, desmosome associated protein	keratin 8, type II
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytoplasm Intermediate Filament Plasma Membrane Cell-cell Junction Membrane Nuclear Speck Desmosome Exon-exon Junction Complex Catalytic Step 2 Spliceosome	Nucleus Nucleoplasm Cytoplasm Intermediate Filament Cell-cell Junction Dystrophin-associated Glycoprotein Complex Nuclear Matrix Z Disc Sarcolemma Costamere Keratin Filament Intermediate Filament Cytoskeleton Extracellular Vesicular Exosome
	Molecular Function	DNA Binding Structural Molecule Activity Poly(A) RNA Binding	Structural Molecule Activity Protein Binding Protein Complex Binding Scaffold Protein Binding
	Biological Process	MRNA Splicing, Via Spliceosome Transcription, DNA-templated Regulation Of Transcription, DNA-templated Cell Adhesion	Viral Process Tumor Necrosis Factor-mediated Signaling Pathway Sarcomere Organization Response To Hydrostatic Pressure Response To Other Organism Cell Differentiation Involved In Embryonic Placenta Development Extrinsic Apoptotic Signaling Pathway Hepatocyte Apoptotic Process
Pathways
Drugs
Diseases
GWAS			Prostate cancer ( 21743057)
Protein-Protein Interactions		16 interactors: CNGB1 CSNK2A1 CTBP1 CTBP2 DYNC1I2 KRT18 KRT19 KRT8 PNISR PPIG PRPF4B RNPS1 SRRM2 SRSF4 YWHAG ZCCHC17	35 interactors: ANXA1 BYSL DEDD DMD EGFR FBXO25 FGFR3 GRB2 HSPA5 IKBKG KPNA2 KRT13 KRT15 KRT17 KRT18 KRT31 KRT38 KRT40 MAPK1 MAPK14 MAPK3 MAPK8 PKD1 PKP1 PLAT PNN PPL QRSL1 RAF1 SUMO1 SUMO2 SUMO3 TCHP TFIP11 TROAP
Entrez ID		5411	3856
HPRD ID		04401	01015
Ensembl ID		ENSG00000100941	ENSG00000170421
Uniprot IDs		Q9H307	P05787 Q7L4M3
PDB IDs
Enriched GO Terms of Interacting Partners?		Viral Process RNA Splicing MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions RNA Processing Hepatocyte Apoptotic Process Negative Regulation Of MRNA Splicing, Via Spliceosome White Fat Cell Differentiation Negative Regulation Of RNA Splicing MRNA Processing Viral Genome Replication RNA Metabolic Process Cell Differentiation Involved In Embryonic Placenta Development Tumor Necrosis Factor-mediated Signaling Pathway MRNA Metabolic Process Termination Of RNA Polymerase II Transcription Gene Expression Sarcomere Organization Golgi To Plasma Membrane CFTR Protein Transport Negative Regulation Of Transcription From RNA Polymerase II Promoter By Histone Modification Regulation Of MRNA Splicing, Via Spliceosome MRNA Export From Nucleus Negative Regulation Of Cellular Metabolic Process DNA-templated Transcription, Termination RNA Export From Nucleus Myofibril Assembly Apoptotic Signaling Pathway Organelle Organization MRNA 3'-end Processing Regulation Of MRNA Processing Negative Regulation Of Chromosome Organization Cellular Response To Tumor Necrosis Factor Cell Differentiation Regulation Of RNA Splicing Extrinsic Apoptotic Signaling Pathway RNA 3'-end Processing Nucleobase-containing Compound Metabolic Process Actomyosin Structure Organization Apoptotic Process Embryonic Placenta Development G2/M Transition Of Mitotic Cell Cycle Nuclear Export MRNA Transport Programmed Cell Death Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Response To Tumor Necrosis Factor Fat Cell Differentiation Cell Death Death	Neurotrophin TRK Receptor Signaling Pathway MAPK Cascade Regulation Of Protein Metabolic Process Cellular Response To Organic Substance Neurotrophin Signaling Pathway Fc-epsilon Receptor Signaling Pathway Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process Tissue Development Fc Receptor Signaling Pathway Signal Transduction By Phosphorylation Apoptotic Process Positive Regulation Of Protein Metabolic Process Programmed Cell Death Innate Immune Response Cell Death Death Immune Response-regulating Signaling Pathway Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Kinase Activity Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 9 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Response To Organic Substance Positive Regulation Of Transferase Activity MyD88-dependent Toll-like Receptor Signaling Pathway Cellular Response To Growth Factor Stimulus Cellular Response To Lipid Response To Growth Factor Anatomical Structure Development Epidermal Growth Factor Receptor Signaling Pathway Toll-like Receptor 4 Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Defense Response Developmental Process Epithelium Development Response To Abiotic Stimulus Regulation Of Immune Response Positive Regulation Of Protein Kinase Activity Cellular Response To Fibroblast Growth Factor Stimulus Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Protein Modification Process
Tagcloud ?		accordingly aforementioned ann arrangement artificial axillary carry categorized dissection drop indication input leaving lymph marker markers necessity network nodal node nodes obviate oestrogen output pr predication prediction probabilistic tumour	ccna1 cdh1 circulatory code cohorts ctnnb1 differentially erbb2 explain favorable gata3 gli1 grouped hic1 highlighting interconnected ipa jun mki67 modulate notch1 predicts ptgs2 rassf1 regulators sfn transducers trigger triple
Tagcloud (Difference) ?		accordingly aforementioned ann arrangement artificial axillary carry categorized dissection drop indication input leaving lymph marker markers necessity network nodal node nodes obviate oestrogen output pr predication prediction probabilistic tumour	ccna1 cdh1 circulatory code cohorts ctnnb1 differentially erbb2 explain favorable gata3 gli1 grouped hic1 highlighting interconnected ipa jun mki67 modulate notch1 predicts ptgs2 rassf1 regulators sfn transducers trigger triple
Tagcloud (Intersection) ?