PNN and CTBP2

Number of citations of the paper that reports this interaction (PMID 15542832)
18

Data Source:
HPRD (in vivo)

		PNN	CTBP2
Gene Name		pinin, desmosome associated protein	C-terminal binding protein 2
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytoplasm Intermediate Filament Plasma Membrane Cell-cell Junction Membrane Nuclear Speck Desmosome Exon-exon Junction Complex Catalytic Step 2 Spliceosome	Nucleus Transcriptional Repressor Complex Cell Junction Synapse
	Molecular Function	DNA Binding Structural Molecule Activity Poly(A) RNA Binding	Chromatin Binding Transcription Coactivator Activity Transcription Corepressor Activity Protein Binding Oxidoreductase Activity, Acting On The CH-OH Group Of Donors, NAD Or NADP As Acceptor Retinoic Acid Receptor Binding NAD Binding
	Biological Process	MRNA Splicing, Via Spliceosome Transcription, DNA-templated Regulation Of Transcription, DNA-templated Cell Adhesion	Transcription, DNA-templated Negative Regulation Of Cell Proliferation Viral Genome Replication Positive Regulation Of Chromatin Binding Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Retinoic Acid Receptor Signaling Pathway White Fat Cell Differentiation Oxidation-reduction Process
Pathways			APC truncation mutants have impaired AXIN binding misspliced GSK3beta mutants stabilize beta-catenin T41 mutants of beta-catenin aren't phosphorylated phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex AXIN missense mutants destabilize the destruction complex TCF7L2 mutants don't bind CTBP truncated APC mutants destabilize the destruction complex S45 mutants of beta-catenin aren't phosphorylated Signaling by Wnt APC truncation mutants are not K63 polyubiquitinated repression of WNT target genes S37 mutants of beta-catenin aren't phosphorylated Degradation of beta-catenin by the destruction complex deletions in the AMER1 gene destabilize the destruction complex AMER1 mutants destabilize the destruction complex S33 mutants of beta-catenin aren't phosphorylated AXIN mutants destabilize the destruction complex, activating WNT signaling deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling Signaling by WNT in cancer truncations of AMER1 destabilize the destruction complex
Drugs
Diseases
GWAS			Prostate cancer ( 18264096)
Protein-Protein Interactions		16 interactors: CNGB1 CSNK2A1 CTBP1 CTBP2 DYNC1I2 KRT18 KRT19 KRT8 PNISR PPIG PRPF4B RNPS1 SRRM2 SRSF4 YWHAG ZCCHC17	67 interactors: ACTG1 AKTIP APP BAZ2B BCAS3 BCL3 C15orf39 CASP8AP2 CBX4 CCNH CCR5 CDKN2A CTBP1 CTPS2 DMRTB1 DVL2 EEF1D ELAC2 EP300 FHL3 FLI1 FOXP2 FUNDC1 HIC1 HIST3H3 HOXB5 IKZF1 IKZF2 KLF3 KLF8 LCOR MDM2 MECOM NOL4 NOL4L NRIP1 PLCB1 PNN PPP1R15A PROX1 PSMF1 RAI2 RBBP8 RIMBP3 RPL17 RPL7A RPS28 RPS29 RPS4X RUNX1 SOX13 SOX6 STUB1 STX11 TEAD3 TGIF1 TSHZ3 UBE2I XRCC6 ZBP1 ZBTB18 ZEB1 ZEB2 ZFPM1 ZFPM2 ZNF512B ZNF750
Entrez ID		5411	1488
HPRD ID		04401	04016
Ensembl ID		ENSG00000100941	ENSG00000175029
Uniprot IDs		Q9H307	P56545 Q5SQP8
PDB IDs			2OME
Enriched GO Terms of Interacting Partners?		Viral Process RNA Splicing MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions RNA Processing Hepatocyte Apoptotic Process Negative Regulation Of MRNA Splicing, Via Spliceosome White Fat Cell Differentiation Negative Regulation Of RNA Splicing MRNA Processing Viral Genome Replication RNA Metabolic Process Cell Differentiation Involved In Embryonic Placenta Development Tumor Necrosis Factor-mediated Signaling Pathway MRNA Metabolic Process Termination Of RNA Polymerase II Transcription Gene Expression Sarcomere Organization Golgi To Plasma Membrane CFTR Protein Transport Negative Regulation Of Transcription From RNA Polymerase II Promoter By Histone Modification Regulation Of MRNA Splicing, Via Spliceosome MRNA Export From Nucleus Negative Regulation Of Cellular Metabolic Process DNA-templated Transcription, Termination RNA Export From Nucleus Myofibril Assembly Apoptotic Signaling Pathway Organelle Organization MRNA 3'-end Processing Regulation Of MRNA Processing Negative Regulation Of Chromosome Organization Cellular Response To Tumor Necrosis Factor Cell Differentiation Regulation Of RNA Splicing Extrinsic Apoptotic Signaling Pathway RNA 3'-end Processing Nucleobase-containing Compound Metabolic Process Actomyosin Structure Organization Apoptotic Process Embryonic Placenta Development G2/M Transition Of Mitotic Cell Cycle Nuclear Export MRNA Transport Programmed Cell Death Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Response To Tumor Necrosis Factor Fat Cell Differentiation Cell Death Death	RNA Biosynthetic Process Gene Expression RNA Metabolic Process Transcription, DNA-templated Nucleobase-containing Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Nitrogen Compound Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Gene Expression Regulation Of RNA Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Gene Expression Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Macromolecule Biosynthetic Process Cellular Metabolic Process Positive Regulation Of Cellular Metabolic Process Regulation Of Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Biosynthetic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Metabolic Process Transcription From RNA Polymerase II Promoter Viral Process Metabolic Process Chordate Embryonic Development Embryo Development Ending In Birth Or Egg Hatching Embryo Development Regulation Of Cellular Process Positive Regulation Of Protein Metabolic Process Developmental Process Cellular Process Multicellular Organismal Development Muscle Structure Development Muscle Organ Development Organ Development Positive Regulation Of Cellular Protein Metabolic Process
Tagcloud ?		accordingly aforementioned ann arrangement artificial axillary carry categorized dissection drop indication input leaving lymph marker markers necessity network nodal node nodes obviate oestrogen output pr predication prediction probabilistic tumour	acetylates acetylation corepressor correlating ctbps deacetylases demethylase dimerization ex527 exerts hdac hypoxic influencing interacted kdm1 ligation lsd1 microenvironmental modifying nscs pla proliferating proximity sensors sirt1 transferase unaltered undifferentiated
Tagcloud (Difference) ?		accordingly aforementioned ann arrangement artificial axillary carry categorized dissection drop indication input leaving lymph marker markers necessity network nodal node nodes obviate oestrogen output pr predication prediction probabilistic tumour	acetylates acetylation corepressor correlating ctbps deacetylases demethylase dimerization ex527 exerts hdac hypoxic influencing interacted kdm1 ligation lsd1 microenvironmental modifying nscs pla proliferating proximity sensors sirt1 transferase unaltered undifferentiated
Tagcloud (Intersection) ?