CCBE1 and KLHL12

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid, two hybrid)

		CCBE1	KLHL12
Description		collagen and calcium binding EGF domains 1	kelch like family member 12
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Collagen Trimer Extracellular Space Extracellular Matrix	Cytoplasm Cytosol COPII Vesicle Coat COPII-coated ER To Golgi Transport Vesicle Cytoplasmic Vesicle Cul3-RING Ubiquitin Ligase Complex Centriolar Satellite
	Molecular Function	Protease Binding Calcium Ion Binding Protein Binding Collagen Binding	Protein Binding Identical Protein Binding Ubiquitin-like Ligase-substrate Adaptor Activity
	Biological Process	Angiogenesis Lymph Vessel Development Lymphangiogenesis Sprouting Angiogenesis Respiratory System Process Respiratory Gaseous Exchange By Respiratory System Positive Regulation Of Vascular Endothelial Growth Factor Production Positive Regulation Of Endothelial Cell Migration Positive Regulation Of Protein Processing Lung Development Endothelial Cell Migration Positive Regulation Of Angiogenesis Venous Blood Vessel Morphogenesis Positive Regulation Of Vascular Endothelial Growth Factor Signaling Pathway Positive Regulation Of Lymphangiogenesis Lymphatic Endothelial Cell Migration	Protein Monoubiquitination Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Anatomical Structure Morphogenesis Tissue Development Neural Crest Formation Neural Crest Cell Development Wnt Signaling Pathway Vesicle-mediated Transport Protein Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process COPII Vesicle Coating
Pathways			Degradation of DVL
Drugs
Diseases
GWAS		Age-related hearing impairment ( 24939585) Appendicular lean mass ( 33097823) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Femur bone mineral density x serum urate levels interaction ( 34046847) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Immature fraction of reticulocytes ( 32888494) Major depressive disorder ( 23857890) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean platelet volume ( 32888494) Platelet count ( 32888494) Plateletcrit ( 32888494) PR interval ( 32439900) Pre-treatment viral load in HIV-1 infection ( 31219150) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Schizophrenia x sex interaction ( 34099189) Schizophrenia, bipolar disorder or major depressive disorder ( 34099189)
Interacting Genes		12 interacting genes: CEP55 COPS6 FBXO7 FXR1 INCA1 KLHL12 KRT27 KRT36 LNX1 SIAH2 STX11 TOX4	58 interacting genes: ARAF ATXN1 BAG6 BCL6 C1QTNF2 CARD10 CCBE1 COL8A1 CPSF6 CRTC3 CUL3 DGCR6 DRD4 DVL3 FAM90A1 FBXL17 FGD2 FLNA GLYCTK INMT KEAP1 KLHL2 KLHL24 KLHL3 LNPK LNX1 MAPRE1 MED25 MED28 MPP1 MRPL10 MTNR1A MYO15B NDC80 NTAQ1 PDCD6 PDGFRB PEA15 PLEKHA4 PNKP PRR13 RGL3 RIN1 RIT1 RNF4 RPP25L SDCBP SNX20 SYNE4 TAOK2 TBC1D10C TCEANC TTBK2 UBE2I VEGFB VTA1 ZBP1 ZBTB4
Entrez ID		147372	59349
HPRD ID		08703	13925
Ensembl ID		ENSG00000183287	ENSG00000117153
Uniprot IDs		A0A8Q3WKU1 Q6UXH8	Q53G59 Q9H7R2
PDB IDs			2VPJ 6TTK 6V7O 8OIO 8RBH
Enriched GO Terms of Interacting Partners?		Post-translational Protein Modification Protein Modification By Small Protein Conjugation Modification-dependent Protein Catabolic Process Ubiquitin-protein Transferase Activity Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Structural Constituent Of Skin Epidermis Glial Cytoplasmic Inclusion Classical Lewy Body Lewy Body Corona Lewy Neurite Proteolysis Involved In Protein Catabolic Process Intermediate Filament Organization Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Apoptotic Signaling Pathway Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Nucleus Organization Intermediate Filament Cytoskeleton Organization Keratin Filament Intermediate Filament-based Process Ubiquitin-like Ligase-substrate Adaptor Activity Lewy Body Core	Cul3-RING Ubiquitin Ligase Complex Protein Binding Regulation Of Signal Transduction Modification-dependent Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Ubiquitin-like Ligase-substrate Adaptor Activity Identical Protein Binding Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein Modification Process POZ Domain Binding Proteolysis Involved In Protein Catabolic Process Adenylate Cyclase-inhibiting Dopamine Receptor Signaling Pathway Regulation Of Organelle Organization Regulation Of Cell Communication Regulation Of Signaling Actin Cytoskeleton Organization Positive Regulation Of Signal Transduction Proteasomal Protein Catabolic Process Positive Regulation Of Organelle Organization Cytoskeleton Organization Actin Filament-based Process Paraspeckles Protein K48-linked Ubiquitination Protein Modification By Small Protein Conjugation Regulation Of Cell Motility Regulation Of Intracellular Signal Transduction Positive Regulation Of Cell Motility Positive Regulation Of Cell Communication Positive Regulation Of Signaling Cellular Component Assembly Regulation Of Locomotion Positive Regulation Of Locomotion
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