CCBE1 and KLHL12

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		CCBE1	KLHL12
Gene Name		collagen and calcium binding EGF domains 1	kelch-like family member 12
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Proteinaceous Extracellular Matrix Collagen Trimer Extracellular Space	Golgi Membrane Cytosol ER To Golgi Transport Vesicle Cul3-RING Ubiquitin Ligase Complex
	Molecular Function	Protease Binding Calcium Ion Binding Collagen Binding	Protein Binding
	Biological Process	Lymphangiogenesis Sprouting Angiogenesis Positive Regulation Vascular Endothelial Growth Factor Production Positive Regulation Of Endothelial Cell Migration Positive Regulation Of Protein Processing Positive Regulation Of Angiogenesis Venous Blood Vessel Morphogenesis Positive Regulation Of Vascular Endothelial Growth Factor Signaling Pathway Positive Regulation Of Lymphangiogenesis	Protein Monoubiquitination ER To Golgi Vesicle-mediated Transport Wnt Signaling Pathway COPII Vesicle Coating Negative Regulation Of Canonical Wnt Signaling Pathway
Pathways			misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling TCF dependent signaling in response to WNT RNF mutants show enhanced WNT signaling and proliferation XAV939 inhibits tankyrase, stabilizing AXIN degradation of DVL Signaling by Wnt Signaling by WNT in cancer
Drugs
Diseases
GWAS
Protein-Protein Interactions		5 interactors: CEP55 KLHL12 SIAH2 STX11 TOX4	39 interactors: ARAF ATXN1 BAG6 C1QTNF2 CARD10 CCBE1 COL8A1 CPSF6 CUL3 DGCR6 DRD4 DVL3 FGD2 FLNA GLYCTK INMT KLHL2 KLHL3 LNX1 MED28 MPP1 MRPL10 NDC80 PDGFRB PEF1 PRR13 RIT1 RPP25L SDCBP SNX20 SYNE4 TAOK2 TBC1D10C TTBK2 UBE2I VEGFB VTA1 WDYHV1 ZBP1
Entrez ID		147372	59349
HPRD ID		08703	13925
Ensembl ID		ENSG00000183287	ENSG00000117153
Uniprot IDs		Q6UXH8	Q53G59
PDB IDs			2VPJ
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Wnt Signaling Pathway Establishment Of Vesicle Localization Vesicle Organization Vesicle Localization Regulation Of Canonical Wnt Signaling Pathway Neutrophil Degranulation Cytotoxic T Cell Degranulation Regulation Of Wnt Signaling Pathway Establishment Of Organelle Localization Neutrophil Activation Involved In Immune Response Natural Killer Cell Degranulation Synaptic Vesicle Fusion To Presynaptic Membrane T Cell Mediated Cytotoxicity Organelle Localization Cell Separation After Cytokinesis COPII Vesicle Coating Neutrophil Mediated Immunity Neutrophil Activation COPII-coated Vesicle Budding Natural Killer Cell Activation Involved In Immune Response Natural Killer Cell Mediated Cytotoxicity Natural Killer Cell Mediated Immunity Protein Ubiquitination Vesicle Targeting, To, From Or Within Golgi Protein Modification By Small Protein Conjugation	Regulation Of Signal Transduction Positive Regulation Of Signal Transduction Regulation Of Phosphorylation Regulation Of Signaling Regulation Of Intracellular Signal Transduction Regulation Of Phosphorus Metabolic Process Positive Regulation Of Intracellular Signal Transduction Regulation Of MAPK Cascade Positive Regulation Of MAPK Cascade Positive Regulation Of Phosphorylation Positive Regulation Of Protein Phosphorylation Positive Regulation Of Protein Metabolic Process Regulation Of Protein Metabolic Process Cellular Component Assembly Positive Regulation Of Transferase Activity Positive Regulation Of Metabolic Process Regulation Of Protein Phosphorylation Positive Regulation Of Cellular Protein Metabolic Process Anatomical Structure Morphogenesis Positive Regulation Of Protein Modification Process Positive Regulation Of Protein Serine/threonine Kinase Activity Positive Regulation Of Protein Kinase Activity Adenylate Cyclase-inhibiting Dopamine Receptor Signaling Pathway Positive Regulation Of Kinase Activity Regulation Of Protein Kinase Activity Regulation Of Cellular Protein Metabolic Process Regulation Of Kinase Activity Coronary Vasculature Development Actin Cytoskeleton Organization Positive Regulation Of MAP Kinase Activity Positive Regulation Of Cellular Metabolic Process Intracellular Signal Transduction Chromosome Segregation Actin Filament-based Process Positive Regulation Of Catalytic Activity Anatomical Structure Development Cellular Protein Modification Process Activation Of Protein Kinase Activity Positive Regulation Of JNK Cascade Ubiquitin-dependent Protein Catabolic Process Anatomical Structure Formation Involved In Morphogenesis Modification-dependent Protein Catabolic Process Cell Projection Assembly Regulation Of MAP Kinase Activity Positive Regulation Of Cell Division Positive Regulation Of Stress-activated MAPK Cascade Positive Regulation Of Stress-activated Protein Kinase Signaling Cascade Regulation Of Chemotaxis Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Mitotic Nuclear Division
Tagcloud ?		anomalies autosomal boy bridge bulb color doppler duodenal edema enlargement facial fat4 flat generalized hennekam hs hypertelorism hypoalbuminemia lymphangiectasia lymphangioma lymphatic manifestations manifested recessive retardation superficial teeth thriving unexplained
Tagcloud (Difference) ?		anomalies autosomal boy bridge bulb color doppler duodenal edema enlargement facial fat4 flat generalized hennekam hs hypertelorism hypoalbuminemia lymphangiectasia lymphangioma lymphatic manifestations manifested recessive retardation superficial teeth thriving unexplained
Tagcloud (Intersection) ?