CCBE1 and SIAH2

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		CCBE1	SIAH2
Gene Name		collagen and calcium binding EGF domains 1	siah E3 ubiquitin protein ligase 2
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Proteinaceous Extracellular Matrix Collagen Trimer Extracellular Space	Nucleoplasm Cytoplasm Early Endosome Cytosol Neuron Projection Neuronal Cell Body Intracellular Membrane-bounded Organelle
	Molecular Function	Protease Binding Calcium Ion Binding Collagen Binding	Transcription Corepressor Activity Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Ligase Activity Ubiquitin Conjugating Enzyme Binding
	Biological Process	Lymphangiogenesis Sprouting Angiogenesis Positive Regulation Vascular Endothelial Growth Factor Production Positive Regulation Of Endothelial Cell Migration Positive Regulation Of Protein Processing Positive Regulation Of Angiogenesis Venous Blood Vessel Morphogenesis Positive Regulation Of Vascular Endothelial Growth Factor Signaling Pathway Positive Regulation Of Lymphangiogenesis	Ubiquitin-dependent Protein Catabolic Process Cell Cycle Small GTPase Mediated Signal Transduction Axon Guidance Protein Ubiquitination Regulation Of Protein Ubiquitination Negative Regulation Of Apoptotic Process Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Cellular Protein Catabolic Process Negative Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways			Axon guidance Netrin-1 signaling
Drugs
Diseases
GWAS			Breast cancer ( 22951594)
Protein-Protein Interactions		5 interactors: CEP55 KLHL12 SIAH2 STX11 TOX4	39 interactors: AFF1 ATN1 CACYBP CCBE1 DCC DYRK2 EEF1D EGLN3 HIPK2 HIPK3 MYD88 OPRM1 PEG10 PEG3 PIAS1 PIAS2 PIAS3 PML POU2AF1 PSMD4 RBBP8 SETD2 SNCA SNCAIP SPRY2 STAT3 SYP TINF2 TP53BP2 TPX2 TRAF2 UBE2D1 UBE2D2 UBE2D3 UBE2I UBE2L6 USP13 USP19 VAV1
Entrez ID		147372	6478
HPRD ID		08703	03737
Ensembl ID		ENSG00000183287	ENSG00000181788
Uniprot IDs		Q6UXH8	O43255
PDB IDs
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Wnt Signaling Pathway Establishment Of Vesicle Localization Vesicle Organization Vesicle Localization Regulation Of Canonical Wnt Signaling Pathway Neutrophil Degranulation Cytotoxic T Cell Degranulation Regulation Of Wnt Signaling Pathway Establishment Of Organelle Localization Neutrophil Activation Involved In Immune Response Natural Killer Cell Degranulation Synaptic Vesicle Fusion To Presynaptic Membrane T Cell Mediated Cytotoxicity Organelle Localization Cell Separation After Cytokinesis COPII Vesicle Coating Neutrophil Mediated Immunity Neutrophil Activation COPII-coated Vesicle Budding Natural Killer Cell Activation Involved In Immune Response Natural Killer Cell Mediated Cytotoxicity Natural Killer Cell Mediated Immunity Protein Ubiquitination Vesicle Targeting, To, From Or Within Golgi Protein Modification By Small Protein Conjugation	Regulation Of Nitrogen Compound Metabolic Process Apoptotic Process Regulation Of Metabolic Process Programmed Cell Death Cell Death Regulation Of Cellular Process Death Positive Regulation Of Metabolic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Gene Expression Regulation Of Signaling Regulation Of Signal Transduction Regulation Of Transcription, DNA-templated Cellular Response To Stress Regulation Of Protein Metabolic Process Response To Growth Factor Protein Catabolic Process Protein Modification By Small Protein Conjugation Positive Regulation Of Protein Metabolic Process Positive Regulation Of Signal Transduction Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Modification-dependent Protein Catabolic Process Protein Sumoylation Response To Organic Substance Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Regulation Of Cellular Protein Metabolic Process Proteasomal Protein Catabolic Process Cellular Protein Catabolic Process Toll-like Receptor 4 Signaling Pathway Cellular Response To Growth Factor Stimulus Response To Stress Negative Regulation Of Cellular Metabolic Process Cellular Response To Stimulus Innate Immune Response Positive Regulation Of Proteolysis Regulation Of Cell Death Immune Response Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Cellular Response To Organic Substance Cellular Protein Modification Process Cellular Macromolecule Catabolic Process Defense Response Negative Regulation Of Biosynthetic Process Regulation Of Proteolysis Toll-like Receptor Signaling Pathway
Tagcloud ?		anomalies autosomal boy bridge bulb color doppler duodenal edema enlargement facial fat4 flat generalized hennekam hs hypertelorism hypoalbuminemia lymphangiectasia lymphangioma lymphatic manifestations manifested recessive retardation superficial teeth thriving unexplained	adding complexity decisions determines e3 fail fate favoring feedback finger hipk2 homeodomain inactivated interferes ligase loop preferentially proline stimulates switch termination ubiquitin ubiquitination uncovers waf1 xaf1 xiap zinc znf313
Tagcloud (Difference) ?		anomalies autosomal boy bridge bulb color doppler duodenal edema enlargement facial fat4 flat generalized hennekam hs hypertelorism hypoalbuminemia lymphangiectasia lymphangioma lymphatic manifestations manifested recessive retardation superficial teeth thriving unexplained	adding complexity decisions determines e3 fail fate favoring feedback finger hipk2 homeodomain inactivated interferes ligase loop preferentially proline stimulates switch termination ubiquitin ubiquitination uncovers waf1 xaf1 xiap zinc znf313
Tagcloud (Intersection) ?