ADRA1D and SNTA1

Number of citations of the paper that reports this interaction (PubMedID 15123239)
0

Data Source:
BioGRID (unspecified method)
HPRD (two hybrid)

		ADRA1D	SNTA1
Description		adrenoceptor alpha 1D	syntrophin alpha 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane	Cytoplasm Cytoskeleton Plasma Membrane Dystrophin-associated Glycoprotein Complex Syntrophin Complex Membrane Lateral Plasma Membrane Neuromuscular Junction Protein-containing Complex Sarcolemma Anchoring Junction
	Molecular Function	G Protein-coupled Receptor Activity Adrenergic Receptor Activity Alpha1-adrenergic Receptor Activity Protein Binding Identical Protein Binding	Actin Binding Structural Molecule Activity Protein Binding Calmodulin Binding Sodium Channel Regulator Activity PDZ Domain Binding Transmembrane Transporter Binding Nitric-oxide Synthase Binding ATPase Binding
	Biological Process	Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Cell-cell Signaling Positive Regulation Of Cell Population Proliferation Positive Regulation Of MAPK Cascade Positive Regulation Of Vasoconstriction Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Neuron-glial Cell Signaling	Regulation Of Heart Rate Muscle Contraction Regulation Of Ventricular Cardiac Muscle Cell Membrane Repolarization Ventricular Cardiac Muscle Cell Action Potential Regulation Of Sodium Ion Transmembrane Transport
Pathways		Adrenoceptors G alpha (q) signalling events G alpha (12/13) signalling events	Formation of the dystrophin-glycoprotein complex (DGC) Formation of the dystrophin-glycoprotein complex (DGC)
Drugs		Amphetamine Midodrine Ranolazine Cabergoline Ropinirole Dapiprazole Dihydroergotamine Amitriptyline Alfuzosin Alfuzosin Norepinephrine Mirtazapine Phenylephrine Prochlorperazine Prazosin Prazosin Imipramine Chlorpromazine Buspirone Nortriptyline Amoxapine Clonidine Doxazosin Labetalol Nicardipine Verapamil Epinephrine Phentolamine Ergotamine Tizanidine Tamsulosin Paroxetine Methoxamine Fenoldopam Dobutamine Quinidine Phenoxybenzamine Maprotiline Oxymetazoline Ergoloid mesylate Promethazine Carvedilol Carvedilol Doxepin Desipramine Terazosin Escitalopram Pergolide Bromocriptine Quetiapine Mephentermine Methotrimeprazine Dextroamphetamine Dronedarone R450 Epicept NP-1 Sertindole Mianserin Pizotifen Silodosin Ocaperidone Droxidopa Xylometazoline Tetryzoline Perospirone Dosulepin Etoperidone Lorpiprazole Cirazoline Synephrine Arotinolol Moxisylyte Aranidipine Pipamperone Racepinephrine Dihydroergocornine DL-Methylephedrine Indigotindisulfonic acid Tiapride Dihydroergocristine
Diseases			Long QT syndrome, including: Romano-Ward syndrome; Jervell and Lange-Nielsen syndrome (JLNS)
GWAS		Paneth cell defects in Crohn's disease ( 28352666) Preeclampsia ( 23551011) Sense of smell ( 26632684)	HDL cholesterol x physical activity interaction (1df test) ( 30670697) HDL cholesterol x physical activity interaction (2df test) ( 30670697)
Interacting Genes		8 interacting genes: ADRA1A FLNC LNX1 NOS1 SNTA1 SNTB1 SNTB2 SNTG1	76 interacting genes: ABCA1 ABCC4 ACTA2 ADAMTS6 ADGRB1 ADGRB2 ADGRB3 ADH5 ADRA1D ADRA2A ADRB1 AGTR2 ATP2B2 ATP6V0B C3AR1 CALM1 CD3E CNKSR2 COPB1 DGKZ DMD DTNA DTNB ENTREP3 F8A1 FABP1 GDA GLS GLS2 GOLGA2 GRB2 GUCY1A2 HTR2B HTR2C IL2RA IL9 ITGB5 KCNA4 KCNA5 KCNJ10 KCNJ12 KCNJ15 KCNJ4 KIF1B LMO1 MAP4 MAPK12 MAS1 MAST1 MCM7 MED8 MTMR2 NAT1 NMU NOS1 PFN2 PRLHR PSKH1 RPS6KA1 SCN1A SCN4A SCN5A SCTR SLC16A7 SLC1A7 SLC2A3 SLC6A3 SSTR1 TGFA TIAM1 TLX3 TRA TRBV12-3 UTRN VANGL2 XRCC6
Entrez ID		146	6640
HPRD ID		00079	03009
Ensembl ID		ENSG00000171873	ENSG00000101400
Uniprot IDs		B0ZBE0 P25100	B3KTR0 Q13424
PDB IDs
Enriched GO Terms of Interacting Partners?		Dystrophin-associated Glycoprotein Complex Sarcolemma Actin Binding Muscle Contraction Calmodulin Binding Structural Molecule Activity Syntrophin Complex Muscle System Process PDZ Domain Binding Cytoskeleton Regulation Of Ventricular Cardiac Muscle Cell Membrane Repolarization Regulation Of The Force Of Heart Contraction Regulation Of Heart Contraction Sodium Channel Regulator Activity Regulation Of Membrane Repolarization Regulation Of Sodium Ion Transmembrane Transport Regulation Of Blood Circulation Protein-containing Complex Regulation Of Action Potential Negative Regulation Of Heart Rate Involved In Baroreceptor Response To Increased Systemic Arterial Blood Pressure Regulation Of Sodium Ion Transport Caveola Regulation Of Cardiac Muscle Contraction Anchoring Junction Cytoplasm Positive Regulation Of The Force Of Heart Contraction By Epinephrine-norepinephrine Positive Regulation Of Heart Rate By Epinephrine-norepinephrine Regulation Of Membrane Potential Phospholipase C-activating Adrenergic Receptor Signaling Pathway Norepinephrine-epinephrine Vasoconstriction Involved In Regulation Of Systemic Arterial Blood Pressure Regulation Of Striated Muscle Contraction Focal Adhesion Synaptic Signaling By Nitric Oxide Regulation Of Heart Rate Pilomotor Reflex Alpha1-adrenergic Receptor Activity Positive Regulation Of The Force Of Heart Contraction By Chemical Signal Nitric-oxide Synthase Activity Negative Regulation Of Serotonin Uptake Tetrahydrobiopterin Binding Positive Regulation Of Membrane Repolarization During Ventricular Cardiac Muscle Cell Action Potential Positive Regulation Of Membrane Repolarization During Cardiac Muscle Cell Action Potential Peptidyl-cysteine S-nitrosylase Activity Z Disc Regulation Of System Process Transmembrane Transporter Binding Regulation Of Serotonin Uptake Blood Vessel Diameter Maintenance Neuron-glial Cell Signaling Regulation Of Tube Size	Plasma Membrane System Process Regulation Of System Process Membrane G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Activity Regulation Of Blood Circulation Circulatory System Process Vascular Process In Circulatory System Monoatomic Ion Channel Complex Regulation Of Multicellular Organismal Process Regulation Of Heart Contraction Blood Vessel Diameter Maintenance Regulation Of Tube Size Basolateral Plasma Membrane Monoatomic Ion Transmembrane Transport Regulation Of Biological Quality Transmembrane Transport Muscle Contraction Inorganic Ion Transmembrane Transport Metal Ion Transport Monoatomic Ion Transport Regulation Of Heart Rate Inorganic Cation Transmembrane Transport Regulation Of Membrane Potential Monoatomic Cation Transmembrane Transport Monoatomic Cation Transport Cardiac Muscle Cell Action Potential Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Muscle System Process Synapse Inward Rectifier Potassium Channel Activity Synaptic Signaling Vasodilation Intracellular Signaling Cassette Regulation Of Monoatomic Ion Transmembrane Transport Adrenergic Receptor Activity CGMP-mediated Signaling Calcium-mediated Signaling Action Potential Potassium Ion Transport Regulation Of Blood Pressure Regulation Of Muscle Contraction Regulation Of Monoatomic Ion Transport Voltage-gated Sodium Channel Complex Signal Transduction Angiotensin-mediated Vasodilation Involved In Regulation Of Systemic Arterial Blood Pressure Cardiac Muscle Cell Action Potential Involved In Contraction Regulation Of Sodium Ion Transmembrane Transport Positive Regulation Of Multicellular Organismal Process
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