COMT and VKORC1

Number of citations of the paper that reports this interaction (PMID 21103663)
2

Data Source:
BioGRID (two hybrid)

		COMT	VKORC1
Gene Name		catechol-O-methyltransferase	vitamin K epoxide reductase complex, subunit 1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Mitochondrion Cytosol Plasma Membrane Membrane Integral Component Of Membrane Axon Dendritic Spine Cell Body Postsynaptic Membrane Extracellular Vesicular Exosome	Endoplasmic Reticulum Membrane Integral Component Of Membrane
	Molecular Function	Magnesium Ion Binding Protein Binding O-methyltransferase Activity Catechol O-methyltransferase Activity	Vitamin-K-epoxide Reductase (warfarin-sensitive) Activity Quinone Binding
	Biological Process	Xenobiotic Metabolic Process Synaptic Transmission Female Pregnancy Learning Short-term Memory Estrogen Metabolic Process Response To Organic Cyclic Compound Cellular Response To Phosphate Starvation Methylation Response To Lipopolysaccharide Developmental Process Negative Regulation Of Renal Sodium Excretion Neurotransmitter Catabolic Process Neurotransmitter Biosynthetic Process Dopamine Catabolic Process Response To Drug Small Molecule Metabolic Process Negative Regulation Of Dopamine Metabolic Process Response To Pain Multicellular Organismal Reproductive Process Negative Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Homocysteine Metabolic Process Regulation Of Sensory Perception Of Pain	Blood Coagulation Drug Metabolic Process Peptidyl-glutamic Acid Carboxylation Vitamin K Metabolic Process Post-translational Protein Modification Cellular Protein Metabolic Process Oxidation-reduction Process Bone Development
Pathways		Defective OPLAH causes 5-oxoprolinase deficiency (OPLAHD) Defective AHCY causes Hypermethioninemia with S-adenosylhomocysteine hydrolase deficiency (HMAHCHD) Dopamine clearance from the synaptic cleft Defective MAT1A causes Methionine adenosyltransferase deficiency (MATD) Defective TPMT causes Thiopurine S-methyltransferase deficiency (TPMT deficiency) Defective UGT1A4 causes hyperbilirubinemia Enzymatic degradation of dopamine by COMT Enzymatic degradation of Dopamine by monoamine oxidase Metabolic disorders of biological oxidation enzymes Phase II conjugation Methylation Defective UGT1A1 causes hyperbilirubinemia Neurotransmitter Clearance In The Synaptic Cleft Defective SLC35D1 causes Schneckenbecken dysplasia (SCHBCKD) Biological oxidations Defective GGT1 causes Glutathionuria (GLUTH) Defective GCLC causes Hemolytic anemia due to gamma-glutamylcysteine synthetase deficiency (HAGGSD) Defective GSS causes Glutathione synthetase deficiency (GSS deficiency) Transmission across Chemical Synapses	Post-translational protein modification Gamma carboxylation, hypusine formation and arylsulfatase activation Gamma-carboxylation, transport, and amino-terminal cleavage of proteins
Drugs		S-Adenosylmethionine Tolcapone Entacapone 3,5-Dinitrocatechol BIA N-{3-[5-(6-Amino-Purin-9-Yl)-3,4-Dihydroxy-Tetrahydro-Furan-2-Yl]-Allyl}-2,3-Dihydroxy-5-Nitro-Benzamide Nialamide (3,4-DIHYDROXY-2-NITROPHENYL)(PHENYL)METHANONE 7,8-dihydroxy-4-phenyl-2H-chromen-2-one	Menadione Dicumarol Phenindione Warfarin Phenprocoumon Acenocoumarol
Diseases
GWAS			Warfarin maintenance dose ( 18535201 20833655 19300499)
Protein-Protein Interactions		10 interactors: ACE CDC27 KRT31 KRT40 KRTAP5-9 LITAF RGS2 TRIP13 VKORC1 XRN2	80 interactors: AHSG APLP2 APOA1 APOA2 APOC1 APOC3 APOC4 ARL6IP5 ASGR1 ASGR2 ATP5G3 ATP6AP2 BCAP31 C1S CCDC12 CCDC167 CD63 CD81 CD9 CLDN10 CNN3 COMT CXADR DPM2 ECHDC1 FGG FGL1 FIS1 FTL GJB1 HAMP HDAC6 HOMER2 HP HPR HSD17B7 IFITM3 JAGN1 KCNK17 LIG4 METTL7B MSMO1 MSRB1 MT1X PCDH1 PCMT1 PDIA6 PIGH PLP2 PPA2 PPIB PROCR REEP5 RMDN1 RMND5A SAA1 SAT1 SERPINA1 SLC15A3 SLC25A1 SLC31A2 SNORA12 SPTSSA STAT6 SURF4 TF TMBIM4 TMEM120A TMEM134 TMEM176A TMEM230 TMEM242 TMEM256 TMEM45B TRAM1 TREX1 VAPB YIF1A ZCCHC24 ZMYM6NB
Entrez ID		1312	79001
HPRD ID		00284	10540
Ensembl ID		ENSG00000093010	ENSG00000167397
Uniprot IDs		P21964	Q9BQB6
PDB IDs		3A7E 3BWM 3BWY
Enriched GO Terms of Interacting Partners?		Spermatogenesis Male Gamete Generation Gamete Generation Sexual Reproduction Multicellular Organismal Reproductive Process Multicellular Organism Reproduction Reproduction Negative Regulation Of Gap Junction Assembly Cell Proliferation In Bone Marrow Single Organism Reproductive Process Positive Regulation Of Peptidyl-cysteine S-nitrosylation Developmental Process Reproductive Process Positive Regulation Of Peptidyl-tyrosine Autophosphorylation Regulation Of Renal Output By Angiotensin Angiotensin Catabolic Process In Blood Multicellular Organismal Protein Catabolic Process Multicellular Organismal Protein Metabolic Process Regulation Of Adrenergic Receptor Signaling Pathway Regulation Of Hematopoietic Stem Cell Proliferation Vitamin K Metabolic Process Positive Regulation Of Cardiac Muscle Contraction Negative Regulation Of CAMP-mediated Signaling Hormone Catabolic Process Negative Regulation Of Phospholipase Activity Metaphase/anaphase Transition Of Mitotic Cell Cycle Relaxation Of Vascular Smooth Muscle Relaxation Of Smooth Muscle Negative Regulation Of Cardiac Muscle Hypertrophy Positive Regulation Of Striated Muscle Contraction Negative Regulation Of Muscle Hypertrophy Angiotensin Maturation Epidermis Development Regulation Of Angiotensin Metabolic Process Peptide Catabolic Process Regulation Of Blood Volume By Renin-angiotensin Hematopoietic Stem Cell Differentiation Arachidonic Acid Secretion Positive Regulation Of Microtubule Polymerization Peptidyl-glutamic Acid Carboxylation Relaxation Of Cardiac Muscle Regulation Of Systemic Arterial Blood Pressure By Circulatory Renin-angiotensin Negative Regulation Of Transferase Activity Female Meiosis I Negative Regulation Of NF-kappaB Import Into Nucleus Negative Regulation Of Smooth Muscle Contraction Blood Circulation Positive Regulation Of Protein Autophosphorylation Negative Regulation Of Lipase Activity Neutrophil Mediated Immunity	Cholesterol Metabolic Process Chemical Homeostasis Sterol Metabolic Process Transport Negative Regulation Of Very-low-density Lipoprotein Particle Remodeling Phospholipid Efflux Homeostatic Process Steroid Metabolic Process Platelet Degranulation Response To Stress Vesicle-mediated Transport High-density Lipoprotein Particle Remodeling Protein-lipid Complex Assembly Cellular Metal Ion Homeostasis Negative Regulation Of Lipase Activity Cellular Chemical Homeostasis Lipid Metabolic Process Cellular Cation Homeostasis Ion Homeostasis Alcohol Metabolic Process Cellular Homeostasis Cellular Ion Homeostasis Metal Ion Homeostasis Plasma Lipoprotein Particle Remodeling Platelet Activation Cholesterol Efflux Acute Inflammatory Response Positive Regulation Of Cholesterol Esterification Blood Coagulation Hemostasis Plasma Lipoprotein Particle Clearance Regulation Of Cholesterol Transport Lipid Biosynthetic Process Transition Metal Ion Homeostasis Regulation Of Cholesterol Esterification Negative Regulation Of Cholesterol Transport Acute-phase Response Calcium-mediated Signaling Using Intracellular Calcium Source Lipoprotein Metabolic Process Negative Regulation Of Cholesterol Import Glycerolipid Metabolic Process Defense Response Cell Activation Lipid Homeostasis Reverse Cholesterol Transport Regulation Of Lipid Catabolic Process Regulation Of Cholesterol Import Regulation Of Plasma Lipoprotein Particle Levels Regulation Of Body Fluid Levels Cholesterol Transport
Tagcloud ?		3h altering alters c6 catechol catecholamines dopamine fourfold hek293 heterologous hplc kinetic km metabolizes monoamine neurotransmitter norepinephrine plasmalemmal potencies retention ro saturation serotonin substrates transporter transporters tropolone uptake velocity	arg98trp arginine carboxylase carboxylated carboxylation catalyzes clotting colocalization confocal consequence di disrupts episodes epoxide exits hydroquinone pathophysiology reductase restores silico suffer supplementation supplemented supraphysiological unrelated vitamin vkcfd2 vkd
Tagcloud (Difference) ?		3h altering alters c6 catechol catecholamines dopamine fourfold hek293 heterologous hplc kinetic km metabolizes monoamine neurotransmitter norepinephrine plasmalemmal potencies retention ro saturation serotonin substrates transporter transporters tropolone uptake velocity	arg98trp arginine carboxylase carboxylated carboxylation catalyzes clotting colocalization confocal consequence di disrupts episodes epoxide exits hydroquinone pathophysiology reductase restores silico suffer supplementation supplemented supraphysiological unrelated vitamin vkcfd2 vkd
Tagcloud (Intersection) ?