COMT and RHBDL1

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid)

		COMT	RHBDL1
Name		catechol-O-methyltransferase	rhomboid like 1
Structure			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Membrane Axon Dendrite Vesicle Synapse Extracellular Exosome	Plasma Membrane Membrane
	Molecular Function	Magnesium Ion Binding Protein Binding Methyltransferase Activity O-methyltransferase Activity Catechol O-methyltransferase Activity Transferase Activity Metal Ion Binding	Serine-type Endopeptidase Activity Protein Binding Peptidase Activity Serine-type Peptidase Activity Hydrolase Activity
	Biological Process	Behavioral Fear Response Response To Hypoxia Kidney Development Synaptic Transmission, Dopaminergic Startle Response Response To Amphetamine Renin Secretion Into Blood Stream Glycogen Metabolic Process Catecholamine Metabolic Process Lipid Metabolic Process Prostaglandin Metabolic Process Response To Stress Response To Oxidative Stress Learning Or Memory Learning Memory Regulation Of Blood Pressure Visual Learning Response To Temperature Stimulus Response To Xenobiotic Stimulus Response To Wounding Response To Toxic Substance Gene Expression Dopamine Secretion Cellular Response To Phosphate Starvation Cerebellar Cortex Morphogenesis Response To Food Methylation Developmental Process Glomerulus Development Cholesterol Efflux Multicellular Organismal Response To Stress Response To Cytokine Multicellular Organism Growth Exploration Behavior Renal Sodium Excretion Norepinephrine Metabolic Process Dopamine Metabolic Process Dopamine Catabolic Process Catecholamine Catabolic Process Fear Response Habituation Norepinephrine Secretion Cognition Detection Of Temperature Stimulus Involved In Sensory Perception Of Pain Response To Corticosterone Artery Development Cellular Response To Cocaine Mastication Renal Albumin Absorption Renal Filtration Response To Salt Response To Dopamine Response To Angiotensin	Proteolysis Signal Transduction
Pathways		Methylation Enzymatic degradation of dopamine by COMT Enzymatic degradation of Dopamine by monoamine oxidase Potential therapeutics for SARS	None
Drugs		Ademetionine Tolcapone Entacapone 3,5-Dinitrocatechol 2-Methoxyestradiol BIA N-[(E)-3-[(2R,3S,4R,5R)-5-(6-Aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]prop-2-enyl]-2,3-dihydroxy-5-nitrobenzamide Nialamide (3,4-DIHYDROXY-2-NITROPHENYL)(PHENYL)METHANONE 7,8-dihydroxy-4-phenyl-2H-chromen-2-one Opicapone	None
GWAS		Serum metabolite levels ( 23093944 ) Systolic blood pressure x alcohol consumption interaction (2df test) ( 29912962 ) Urinary metabolite levels in chronic kidney disease ( 31959995 ) Urinary metabolite modules (eigenmetabolites) in chronic kidney disease ( 31959995 )	Body mass index ( 26426971 ) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098 )
Interacting Genes		68 interacting genes: ACE AQP7 AVPR2 BEST2 CCL4L2 CDC27 CDC42 CNR2 CREB3L1 EMD FAM209A FFAR3 FXR2 GET1 GJB1 GJB3 GJB4 GJB5 GLP1R GPR152 GPR161 GPR42 HIBADH HSD3B7 KCNK5 KRT31 KRT40 KRTAP5-9 LITAF MTNR1A MYADML2 NIPAL4 OTOP3 PGAP2 PLPP6 REEP4 RGS2 RHBDD2 RHBDL1 S1PR3 SELENOK SLC10A6 SLC16A7 SLC2A5 SLC35A4 SLC35F1 SLC39A1 SLC39A2 SLC48A1 SLC71A2 SLC7A8 SMIM1 THSD7A TLCD4 TMEM100 TMEM120B TMEM14B TMEM14C TMEM187 TMEM205 TMEM222 TMEM50A TRHR TRIP13 VAMP3 VAMP5 VKORC1 XRN2	13 interacting genes: ABHD16A APOD ARLN COMT FXYD6 KRTAP10-8 KRTAP2-3 KRTAP2-4 KRTAP6-3 MFF SPTSSA TRARG1 VAC14
Entrez ID		1312	9028
HPRD ID		00284	07050
Ensembl ID		ENSG00000093010	ENSG00000103269
Uniprot IDs		A0A140VJG8 P21964	O75783
PDB IDs		3A7E 3BWM 3BWY 4PYI 4PYJ 4PYK 4XUC 4XUD 4XUE 5LSA 6I3C 6I3D	Not available
GO Terms Enriched among Interactors		Membrane Transmembrane Transport Plasma Membrane G Protein-coupled Receptor Activity Connexin Complex Gap Junction Channel Activity G Protein-coupled Receptor Signaling Pathway Gap Junction Transmembrane Transporter Activity Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Nuclear Inner Membrane Regulation Of Blood Pressure Respiratory Burst After Phagocytosis Protein Binding Regulation Of Systemic Arterial Blood Pressure Mediated By A Chemical Signal Positive Regulation Of Blood Pressure Heme Metabolic Process Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Cell Differentiation Regulation Of Gap Junction Assembly Respiratory Burst Involved In Defense Response	Intermediate Filament Keratin Filament