COMT and TRIP13

Number of citations of the paper that reports this interaction (PMID 16189514)
699

Data Source:
BioGRID (two hybrid, two hybrid, two hybrid)
HPRD (two hybrid)

		COMT	TRIP13
Gene Name		catechol-O-methyltransferase	thyroid hormone receptor interactor 13
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Mitochondrion Cytosol Plasma Membrane Membrane Integral Component Of Membrane Axon Dendritic Spine Cell Body Postsynaptic Membrane Extracellular Vesicular Exosome	Male Germ Cell Nucleus Nucleus
	Molecular Function	Magnesium Ion Binding Protein Binding O-methyltransferase Activity Catechol O-methyltransferase Activity	Transcription Cofactor Activity Protein Binding ATP Binding Identical Protein Binding
	Biological Process	Xenobiotic Metabolic Process Synaptic Transmission Female Pregnancy Learning Short-term Memory Estrogen Metabolic Process Response To Organic Cyclic Compound Cellular Response To Phosphate Starvation Methylation Response To Lipopolysaccharide Developmental Process Negative Regulation Of Renal Sodium Excretion Neurotransmitter Catabolic Process Neurotransmitter Biosynthetic Process Dopamine Catabolic Process Response To Drug Small Molecule Metabolic Process Negative Regulation Of Dopamine Metabolic Process Response To Pain Multicellular Organismal Reproductive Process Negative Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Homocysteine Metabolic Process Regulation Of Sensory Perception Of Pain	Oocyte Maturation Double-strand Break Repair Transcription From RNA Polymerase II Promoter Synaptonemal Complex Assembly Reciprocal Meiotic Recombination Male Meiosis I Female Meiosis I Spermatogenesis Spermatid Development Oogenesis Regulation Of Nucleic Acid-templated Transcription
Pathways		Defective OPLAH causes 5-oxoprolinase deficiency (OPLAHD) Defective AHCY causes Hypermethioninemia with S-adenosylhomocysteine hydrolase deficiency (HMAHCHD) Dopamine clearance from the synaptic cleft Defective MAT1A causes Methionine adenosyltransferase deficiency (MATD) Defective TPMT causes Thiopurine S-methyltransferase deficiency (TPMT deficiency) Defective UGT1A4 causes hyperbilirubinemia Enzymatic degradation of dopamine by COMT Enzymatic degradation of Dopamine by monoamine oxidase Metabolic disorders of biological oxidation enzymes Phase II conjugation Methylation Defective UGT1A1 causes hyperbilirubinemia Neurotransmitter Clearance In The Synaptic Cleft Defective SLC35D1 causes Schneckenbecken dysplasia (SCHBCKD) Biological oxidations Defective GGT1 causes Glutathionuria (GLUTH) Defective GCLC causes Hemolytic anemia due to gamma-glutamylcysteine synthetase deficiency (HAGGSD) Defective GSS causes Glutathione synthetase deficiency (GSS deficiency) Transmission across Chemical Synapses
Drugs		S-Adenosylmethionine Tolcapone Entacapone 3,5-Dinitrocatechol BIA N-{3-[5-(6-Amino-Purin-9-Yl)-3,4-Dihydroxy-Tetrahydro-Furan-2-Yl]-Allyl}-2,3-Dihydroxy-5-Nitro-Benzamide Nialamide (3,4-DIHYDROXY-2-NITROPHENYL)(PHENYL)METHANONE 7,8-dihydroxy-4-phenyl-2H-chromen-2-one
Diseases
GWAS
Protein-Protein Interactions		10 interactors: ACE CDC27 KRT31 KRT40 KRTAP5-9 LITAF RGS2 TRIP13 VKORC1 XRN2	75 interactors: ADAM15 AMDHD2 ARL11 ARSA ASB13 C11orf54 C4orf33 CARD14 CCBL1 CD99 COMT CPSF3L CRMP1 CRYBA2 CYB5R2 DDAH2 DIP2A DPYSL4 DTX2 FNDC3B GALT GLYCTK GPRIN2 GPSM1 HDHD3 KRTAP12-1 KRTAP12-2 KRTAP26-1 KRTAP3-2 LASP1 LNX1 LOXL4 LRR1 LRRC61 M1AP MAD2L1BP MAD2L2 METTL15 MGAT5B MORN3 MPPED2 MVP NIF3L1 NME4 PARK2 PARP11 PBLD PCMTD2 PELI1 PLAC8 PLK3 PLSCR3 PLSCR4 PPP2CA QARS RBPMS RHOXF2 SCP2 SEC24A SELENBP1 SEMA4G SIGLEC5 SMUG1 SPRYD7 STAMBP STAMBPL1 TEX37 THRB TINAGL1 TLDC1 TNRC6A TPT1 WDYHV1 ZNF34 ZNF655
Entrez ID		1312	9319
HPRD ID		00284	05145
Ensembl ID		ENSG00000093010	ENSG00000071539
Uniprot IDs		P21964	Q15645
PDB IDs		3A7E 3BWM 3BWY
Enriched GO Terms of Interacting Partners?		Spermatogenesis Male Gamete Generation Gamete Generation Sexual Reproduction Multicellular Organismal Reproductive Process Multicellular Organism Reproduction Reproduction Negative Regulation Of Gap Junction Assembly Cell Proliferation In Bone Marrow Single Organism Reproductive Process Positive Regulation Of Peptidyl-cysteine S-nitrosylation Developmental Process Reproductive Process Positive Regulation Of Peptidyl-tyrosine Autophosphorylation Regulation Of Renal Output By Angiotensin Angiotensin Catabolic Process In Blood Multicellular Organismal Protein Catabolic Process Multicellular Organismal Protein Metabolic Process Regulation Of Adrenergic Receptor Signaling Pathway Regulation Of Hematopoietic Stem Cell Proliferation Vitamin K Metabolic Process Positive Regulation Of Cardiac Muscle Contraction Negative Regulation Of CAMP-mediated Signaling Hormone Catabolic Process Negative Regulation Of Phospholipase Activity Metaphase/anaphase Transition Of Mitotic Cell Cycle Relaxation Of Vascular Smooth Muscle Relaxation Of Smooth Muscle Negative Regulation Of Cardiac Muscle Hypertrophy Positive Regulation Of Striated Muscle Contraction Negative Regulation Of Muscle Hypertrophy Angiotensin Maturation Epidermis Development Regulation Of Angiotensin Metabolic Process Peptide Catabolic Process Regulation Of Blood Volume By Renin-angiotensin Hematopoietic Stem Cell Differentiation Arachidonic Acid Secretion Positive Regulation Of Microtubule Polymerization Peptidyl-glutamic Acid Carboxylation Relaxation Of Cardiac Muscle Regulation Of Systemic Arterial Blood Pressure By Circulatory Renin-angiotensin Negative Regulation Of Transferase Activity Female Meiosis I Negative Regulation Of NF-kappaB Import Into Nucleus Negative Regulation Of Smooth Muscle Contraction Blood Circulation Positive Regulation Of Protein Autophosphorylation Negative Regulation Of Lipase Activity Neutrophil Mediated Immunity	Negative Regulation Of Epithelial To Mesenchymal Transition Negative Regulation Of Stem Cell Differentiation Catabolic Process Pyrimidine Nucleobase Catabolic Process Negative Regulation Of Mitotic Cell Cycle Phospholipid Scrambling Regulation Of Epithelial To Mesenchymal Transition Metabolic Process Endomembrane System Organization Regulation Of SMAD Protein Import Into Nucleus Negative Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Protein Phosphorylation Phospholipid Transport Carboxylic Acid Catabolic Process Negative Regulation Of Protein Metabolic Process Small Molecule Metabolic Process Negative Regulation Of Apoptotic Process Negative Regulation Of Cell Morphogenesis Involved In Differentiation Negative Regulation Of Programmed Cell Death Dopamine Metabolic Process Regulation Of Protein Autophosphorylation Positive Regulation Of Homocysteine Metabolic Process RRNA Base Methylation Negative Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Glutaminyl-tRNA Aminoacylation Lipid Hydroperoxide Transport Positive Regulation Of Intracellular Cholesterol Transport UDP-glucose Catabolic Process Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Mitochondrial Fusion Cellular Response To Phosphate Starvation Male Meiosis Chromosome Separation Regulation Of Protein Metabolic Process Negative Regulation Of Cell Death Negative Regulation Of Phosphorylation Protein Ubiquitination Regulation Of Apoptotic Process
Tagcloud ?		3h altering alters c6 catechol catecholamines dopamine fourfold hek293 heterologous hplc kinetic km metabolizes monoamine neurotransmitter norepinephrine plasmalemmal potencies retention ro saturation serotonin substrates transporter transporters tropolone uptake velocity	abrogates anaphase apc assembles attached bub3 bubr1 cdc20 centrally checkpoint comet correctly cyclosome delays disassemble disassembled disassembly hela hydrolysis inactivated mad2 mcc mitotic p31 participates spindle subcomplex sufficiently turned
Tagcloud (Difference) ?		3h altering alters c6 catechol catecholamines dopamine fourfold hek293 heterologous hplc kinetic km metabolizes monoamine neurotransmitter norepinephrine plasmalemmal potencies retention ro saturation serotonin substrates transporter transporters tropolone uptake velocity	abrogates anaphase apc assembles attached bub3 bubr1 cdc20 centrally checkpoint comet correctly cyclosome delays disassemble disassembled disassembly hela hydrolysis inactivated mad2 mcc mitotic p31 participates spindle subcomplex sufficiently turned
Tagcloud (Intersection) ?