COMT and TRIP13

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid, two hybrid, two hybrid)
HPRD (two hybrid)

		COMT	TRIP13
Description		catechol-O-methyltransferase	thyroid hormone receptor interactor 13
Image
GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Membrane Axon Dendrite Vesicle Synapse Extracellular Exosome	Male Germ Cell Nucleus Nucleus Chromosome
	Molecular Function	Magnesium Ion Binding Protein Binding Methyltransferase Activity O-methyltransferase Activity Catechol O-methyltransferase Activity Transferase Activity Metal Ion Binding	Nucleotide Binding Transcription Coregulator Activity Protein Binding ATP Binding ATP Hydrolysis Activity Identical Protein Binding
	Biological Process	Behavioral Fear Response Response To Hypoxia Kidney Development Synaptic Transmission, Dopaminergic Startle Response Response To Amphetamine Renin Secretion Into Blood Stream Glycogen Metabolic Process Catecholamine Metabolic Process Lipid Metabolic Process Prostaglandin Metabolic Process Response To Stress Response To Oxidative Stress Learning Or Memory Learning Memory Regulation Of Blood Pressure Visual Learning Response To Temperature Stimulus Response To Xenobiotic Stimulus Response To Wounding Response To Toxic Substance Gene Expression Dopamine Secretion Cellular Response To Phosphate Starvation Cerebellar Cortex Morphogenesis Response To Food Methylation Developmental Process Glomerulus Development Cholesterol Efflux Multicellular Organismal Response To Stress Response To Cytokine Multicellular Organism Growth Exploration Behavior Renal Sodium Excretion Norepinephrine Metabolic Process Dopamine Metabolic Process Dopamine Catabolic Process Catecholamine Catabolic Process Fear Response Habituation Norepinephrine Secretion Cognition Detection Of Temperature Stimulus Involved In Sensory Perception Of Pain Response To Corticosterone Artery Development Cellular Response To Cocaine Mastication Renal Albumin Absorption Renal Filtration Response To Salt Response To Dopamine Response To Angiotensin	Oocyte Maturation Double-strand Break Repair Transcription By RNA Polymerase II Mitotic Spindle Assembly Checkpoint Signaling Synaptonemal Complex Assembly Reciprocal Meiotic Recombination Male Meiosis I Female Meiosis I Spermatogenesis Spermatid Development Cell Differentiation Oogenesis Meiotic Cell Cycle Meiotic Recombination Checkpoint Signaling
Pathways		Methylation Enzymatic degradation of dopamine by COMT Enzymatic degradation of Dopamine by monoamine oxidase Potential therapeutics for SARS
Drugs		Ademetionine Tolcapone Entacapone 3,5-Dinitrocatechol 2-Methoxyestradiol BIA N-[(E)-3-[(2R,3S,4R,5R)-5-(6-Aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]prop-2-enyl]-2,3-dihydroxy-5-nitrobenzamide Nialamide (3,4-DIHYDROXY-2-NITROPHENYL)(PHENYL)METHANONE 7,8-dihydroxy-4-phenyl-2H-chromen-2-one Opicapone
Diseases
GWAS		Serum metabolite levels ( 23093944) Systolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Urinary metabolite levels in chronic kidney disease ( 31959995) Urinary metabolite modules (eigenmetabolites) in chronic kidney disease ( 31959995)	Pancreatic cancer ( 25086665)
Interacting Genes		68 interacting genes: ACE AQP7 AVPR2 BEST2 CCL4L2 CDC27 CDC42 CNR2 CREB3L1 EMD FAM209A FFAR3 FXR2 GET1 GJB1 GJB3 GJB4 GJB5 GLP1R GPR152 GPR161 GPR42 HIBADH HSD3B7 KCNK5 KRT31 KRT40 KRTAP5-9 LITAF MTNR1A MYADML2 NIPAL4 OTOP3 PGAP2 PLPP6 REEP4 RGS2 RHBDD2 RHBDL1 S1PR3 SELENOK SLC10A6 SLC16A7 SLC2A5 SLC35A4 SLC35F1 SLC39A1 SLC39A2 SLC48A1 SLC71A2 SLC7A8 SMIM1 THSD7A TLCD4 TMEM100 TMEM120B TMEM14B TMEM14C TMEM187 TMEM205 TMEM222 TMEM50A TRHR TRIP13 VAMP3 VAMP5 VKORC1 XRN2	113 interacting genes: ACTMAP ADAM15 AMDHD2 ANKRD10 ARL11 ARSA ASB13 BKGD BUB1B C4orf33 CARD14 CD99 CDC20 CDIN1 CEP170B CFP CLIP4 COMT CRMP1 CRYBA2 CYB5R2 DCTN3 DDAH2 DIP2A DPYSL4 DTX2 EEF2KMT FBLN5 FBXO8 FILNC1 FNDC3B GALT GLYCTK GPRIN2 GPSM1 HDHD3 IGFN1 IL2RB INCA1 INTS11 KRTAP12-1 KRTAP12-2 KRTAP12-4 KRTAP26-1 KRTAP3-2 KRTAP6-1 KRTAP6-2 KYAT1 LASP1 LNX1 LOXL4 LRR1 LRRC61 M1AP MAD2L1 MAD2L1BP MBLAC1 MEAK7 METTL15 MGAT5B MORN3 MPPED2 MVP MYEOV NIF3L1 NME4 NTAQ1 PARP11 PAX9 PBLD PCMTD2 PCSK5 PELI1 PLAC8 PLK3 PLSCR3 PLSCR4 POLR2L PPP2CA PRKAA2 PRKN PRR13 PSMB8 QARS1 RBPMS RHOXF2 RNF4 SCP2 SDCBP SEC24A SELENBP1 SEMA3B SEMA4G SHARPIN SIGLEC5 SMUG1 SPMIP9 SPRYD7 SSC4D STAMBP STAMBPL1 SUMO2 TENT5B THRB TINAGL1 TNRC6A TPT1 UBE2I VDR VENTX ZMYM5 ZNF34 ZNF655
Entrez ID		1312	9319
HPRD ID		00284	05145
Ensembl ID		ENSG00000093010	ENSG00000071539
Uniprot IDs		A0A140VJG8 P21964	Q15645
PDB IDs		3A7E 3BWM 3BWY 4PYI 4PYJ 4PYK 4XUC 4XUD 4XUE 5LSA 6I3C 6I3D	5VQ9 5VQA 5WC2 6F0X 6LK0 7L9P
Enriched GO Terms of Interacting Partners?		Membrane Transmembrane Transport Plasma Membrane G Protein-coupled Receptor Activity Connexin Complex Gap Junction Channel Activity G Protein-coupled Receptor Signaling Pathway Gap Junction Transmembrane Transporter Activity Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Nuclear Inner Membrane Regulation Of Blood Pressure Respiratory Burst After Phagocytosis Protein Binding Regulation Of Systemic Arterial Blood Pressure Mediated By A Chemical Signal Positive Regulation Of Blood Pressure Heme Metabolic Process Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Cell Differentiation Regulation Of Gap Junction Assembly Respiratory Burst Involved In Defense Response	Protein Binding Mitotic Checkpoint Complex Hydrolase Activity, Acting On Carbon-nitrogen (but Not Peptide) Bonds Protein K6-linked Ubiquitination Intermediate Filament
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