COMT and ACE

Number of citations of the paper that reports this interaction (PMID 12729939)
4

Data Source:
HPRD (in vivo)

		COMT	ACE
Gene Name		catechol-O-methyltransferase	angiotensin I converting enzyme
Image
Gene Ontology Annotations	Cellular Component	Mitochondrion Cytosol Plasma Membrane Membrane Integral Component Of Membrane Axon Dendritic Spine Cell Body Postsynaptic Membrane Extracellular Vesicular Exosome	Extracellular Region Extracellular Space Lysosome Endosome Plasma Membrane External Side Of Plasma Membrane Integral Component Of Membrane Extracellular Vesicular Exosome
	Molecular Function	Magnesium Ion Binding Protein Binding O-methyltransferase Activity Catechol O-methyltransferase Activity	Actin Binding Endopeptidase Activity Carboxypeptidase Activity Protein Binding Drug Binding Metallopeptidase Activity Exopeptidase Activity Tripeptidyl-peptidase Activity Peptidyl-dipeptidase Activity Zinc Ion Binding Chloride Ion Binding Mitogen-activated Protein Kinase Kinase Binding Bradykinin Receptor Binding Mitogen-activated Protein Kinase Binding
	Biological Process	Xenobiotic Metabolic Process Synaptic Transmission Female Pregnancy Learning Short-term Memory Estrogen Metabolic Process Response To Organic Cyclic Compound Cellular Response To Phosphate Starvation Methylation Response To Lipopolysaccharide Developmental Process Negative Regulation Of Renal Sodium Excretion Neurotransmitter Catabolic Process Neurotransmitter Biosynthetic Process Dopamine Catabolic Process Response To Drug Small Molecule Metabolic Process Negative Regulation Of Dopamine Metabolic Process Response To Pain Multicellular Organismal Reproductive Process Negative Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Homocysteine Metabolic Process Regulation Of Sensory Perception Of Pain	Kidney Development Blood Vessel Remodeling Angiotensin Maturation Angiotensin Catabolic Process In Blood Regulation Of Renal Output By Angiotensin Neutrophil Mediated Immunity Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Regulation Of Systemic Arterial Blood Pressure By Renin-angiotensin Proteolysis Spermatogenesis Regulation Of Blood Pressure Regulation Of Smooth Muscle Cell Migration Regulation Of Vasoconstriction Mononuclear Cell Proliferation Regulation Of Vasodilation Hormone Catabolic Process Peptide Catabolic Process Cellular Protein Metabolic Process Beta-amyloid Metabolic Process Arachidonic Acid Secretion Heart Contraction Regulation Of Angiotensin Metabolic Process Hematopoietic Stem Cell Differentiation Positive Regulation Of Protein Tyrosine Kinase Activity Cell Proliferation In Bone Marrow Positive Regulation Of Peptidyl-tyrosine Autophosphorylation Regulation Of Hematopoietic Stem Cell Proliferation Negative Regulation Of Gap Junction Assembly Positive Regulation Of Peptidyl-cysteine S-nitrosylation
Pathways		Defective OPLAH causes 5-oxoprolinase deficiency (OPLAHD) Defective AHCY causes Hypermethioninemia with S-adenosylhomocysteine hydrolase deficiency (HMAHCHD) Dopamine clearance from the synaptic cleft Defective MAT1A causes Methionine adenosyltransferase deficiency (MATD) Defective TPMT causes Thiopurine S-methyltransferase deficiency (TPMT deficiency) Defective UGT1A4 causes hyperbilirubinemia Enzymatic degradation of dopamine by COMT Enzymatic degradation of Dopamine by monoamine oxidase Metabolic disorders of biological oxidation enzymes Phase II conjugation Methylation Defective UGT1A1 causes hyperbilirubinemia Neurotransmitter Clearance In The Synaptic Cleft Defective SLC35D1 causes Schneckenbecken dysplasia (SCHBCKD) Biological oxidations Defective GGT1 causes Glutathionuria (GLUTH) Defective GCLC causes Hemolytic anemia due to gamma-glutamylcysteine synthetase deficiency (HAGGSD) Defective GSS causes Glutathione synthetase deficiency (GSS deficiency) Transmission across Chemical Synapses	Peptide hormone metabolism Metabolism of Angiotensinogen to Angiotensins
Drugs		S-Adenosylmethionine Tolcapone Entacapone 3,5-Dinitrocatechol BIA N-{3-[5-(6-Amino-Purin-9-Yl)-3,4-Dihydroxy-Tetrahydro-Furan-2-Yl]-Allyl}-2,3-Dihydroxy-5-Nitro-Benzamide Nialamide (3,4-DIHYDROXY-2-NITROPHENYL)(PHENYL)METHANONE 7,8-dihydroxy-4-phenyl-2H-chromen-2-one	Ramipril Fosinopril Trandolapril Benazepril Enalapril Candoxatril Moexipril Lisinopril Perindopril Quinapril Rescinnamine Captopril Cilazapril Spirapril 1-(3-Mercapto-2-Methyl-Propionyl)-Pyrrolidine-2-Carboxylic Acid 2-(Acetylamino)-2-Deoxy-a-D-Glucopyranose Temocapril
Diseases
GWAS			Angiotensin-converting enzyme activity ( 20066004) Metabolic traits ( 21886157) Metabolite levels ( 23281178)
Protein-Protein Interactions		10 interactors: ACE CDC27 KRT31 KRT40 KRTAP5-9 LITAF RGS2 TRIP13 VKORC1 XRN2	4 interactors: AGTR2 BDKRB2 COMT CSNK2A1
Entrez ID		1312	1636
HPRD ID		00284	00108
Ensembl ID		ENSG00000093010	ENSG00000159640
Uniprot IDs		P21964	B4DKH4 P12821
PDB IDs		3A7E 3BWM 3BWY	1O86 1O8A 1UZE 1UZF 2C6F 2C6N 2IUL 2IUX 2OC2 2XY9 2XYD 2YDM 3BKK 3BKL 3L3N 3NXQ 4APH 4APJ 4BXK
Enriched GO Terms of Interacting Partners?		Spermatogenesis Male Gamete Generation Gamete Generation Sexual Reproduction Multicellular Organismal Reproductive Process Multicellular Organism Reproduction Reproduction Negative Regulation Of Gap Junction Assembly Cell Proliferation In Bone Marrow Single Organism Reproductive Process Positive Regulation Of Peptidyl-cysteine S-nitrosylation Developmental Process Reproductive Process Positive Regulation Of Peptidyl-tyrosine Autophosphorylation Regulation Of Renal Output By Angiotensin Angiotensin Catabolic Process In Blood Multicellular Organismal Protein Catabolic Process Multicellular Organismal Protein Metabolic Process Regulation Of Adrenergic Receptor Signaling Pathway Regulation Of Hematopoietic Stem Cell Proliferation Vitamin K Metabolic Process Positive Regulation Of Cardiac Muscle Contraction Negative Regulation Of CAMP-mediated Signaling Hormone Catabolic Process Negative Regulation Of Phospholipase Activity Metaphase/anaphase Transition Of Mitotic Cell Cycle Relaxation Of Vascular Smooth Muscle Relaxation Of Smooth Muscle Negative Regulation Of Cardiac Muscle Hypertrophy Positive Regulation Of Striated Muscle Contraction Negative Regulation Of Muscle Hypertrophy Angiotensin Maturation Epidermis Development Regulation Of Angiotensin Metabolic Process Peptide Catabolic Process Regulation Of Blood Volume By Renin-angiotensin Hematopoietic Stem Cell Differentiation Arachidonic Acid Secretion Positive Regulation Of Microtubule Polymerization Peptidyl-glutamic Acid Carboxylation Relaxation Of Cardiac Muscle Regulation Of Systemic Arterial Blood Pressure By Circulatory Renin-angiotensin Negative Regulation Of Transferase Activity Female Meiosis I Negative Regulation Of NF-kappaB Import Into Nucleus Negative Regulation Of Smooth Muscle Contraction Blood Circulation Positive Regulation Of Protein Autophosphorylation Negative Regulation Of Lipase Activity Neutrophil Mediated Immunity	Regulation Of Renal Sodium Excretion Regulation Of Excretion Dopamine Metabolic Process Vasodilation Catecholamine Metabolic Process Regulation Of Blood Vessel Size Regulation Of Tube Size Phenol-containing Compound Metabolic Process Positive Regulation Of Homocysteine Metabolic Process Cellular Response To Phosphate Starvation Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To Osmotic Stress By P53 Class Mediator Aldosterone Secretion Vasodilation By Angiotensin Involved In Regulation Of Systemic Arterial Blood Pressure Regulation Of Ion Homeostasis Regulation Of Homocysteine Metabolic Process Regulation Of Metanephros Size Negative Regulation Of Secretion Negative Regulation Of Dopamine Metabolic Process G-protein Coupled Receptor Signaling Pathway Coupled To CGMP Nucleotide Second Messenger Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To Osmotic Stress Negative Regulation Of Icosanoid Secretion Regulation Of Kidney Size Renin-angiotensin Regulation Of Aldosterone Production Muscle System Process Regulation Of Hormone Levels Positive Regulation Of Metanephric Glomerulus Development Regulation Of Blood Vessel Size By Renin-angiotensin Regulation Of Apoptotic Process Negative Regulation Of Renal Sodium Excretion Dopamine Catabolic Process Regulation Of Cell Proliferation Lipid Transport Blood Circulation Negative Regulation Of Neurotrophin TRK Receptor Signaling Pathway Catecholamine Catabolic Process Regulation Of Cell Death Lipid Localization Angiotensin-activated Signaling Pathway Negative Regulation Of Norepinephrine Secretion Regulation Of Cell Growth Brain Renin-angiotensin System Regulation Of Response To Osmotic Stress Positive Regulation Of Glomerulus Development Cell Growth Involved In Cardiac Muscle Cell Development Regulation Of Neurotrophin TRK Receptor Signaling Pathway Negative Regulation Of Transport Regulation Of Cellular Amino Acid Metabolic Process Negative Regulation Of Heart Rate Cellular Metal Ion Homeostasis Inflammatory Response
Tagcloud ?		3h altering alters c6 catechol catecholamines dopamine fourfold hek293 heterologous hplc kinetic km metabolizes monoamine neurotransmitter norepinephrine plasmalemmal potencies retention ro saturation serotonin substrates transporter transporters tropolone uptake velocity	aminoguanidine attendant augmentation blue blunted cardioprotection cgmp cilazaprilat ck creatine cyclase fashion guanylate hypoxia indomethacin methylene monoacetate monomethyl myocardium myocyte myocytes nmma nonmyocytes paracrine preservation preserved reoxygenated reoxygenation staurosporine
Tagcloud (Difference) ?		3h altering alters c6 catechol catecholamines dopamine fourfold hek293 heterologous hplc kinetic km metabolizes monoamine neurotransmitter norepinephrine plasmalemmal potencies retention ro saturation serotonin substrates transporter transporters tropolone uptake velocity	aminoguanidine attendant augmentation blue blunted cardioprotection cgmp cilazaprilat ck creatine cyclase fashion guanylate hypoxia indomethacin methylene monoacetate monomethyl myocardium myocyte myocytes nmma nonmyocytes paracrine preservation preserved reoxygenated reoxygenation staurosporine
Tagcloud (Intersection) ?