FBLN2 and PRELP

Number of citations of the paper that reports this interaction (PubMedID 11847210)
0

Data Source:
HPRD (in vitro)

		FBLN2	PRELP
Description		fibulin 2	proline and arginine rich end leucine rich repeat protein
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Matrix Extracellular Vesicle	Extracellular Region Extracellular Space Golgi Lumen Extracellular Matrix Lysosomal Lumen Extracellular Exosome Extracellular Vesicle
	Molecular Function	Extracellular Matrix Structural Constituent Calcium Ion Binding Protein Binding Extracellular Matrix Constituent Conferring Elasticity Extracellular Matrix Binding	Extracellular Matrix Structural Constituent Heparin Binding Extracellular Matrix Structural Constituent Conferring Compression Resistance
	Biological Process	Positive Regulation Of Cell-substrate Adhesion	Skeletal System Development Cellular Senescence
Pathways		Molecules associated with elastic fibres Molecules associated with elastic fibres	Keratan sulfate biosynthesis Keratan sulfate degradation Defective CHST6 causes MCDC1 Defective ST3GAL3 causes MCT12 and EIEE15 Defective B4GALT1 causes B4GALT1-CDG (CDG-2d)
Drugs
Diseases
GWAS		Appendicular lean mass ( 33097823) Bipolar disorder with mood-incongruent psychosis ( 23092984) Body mass index ( 26426971) Hip circumference adjusted for BMI ( 34021172) Response to cognitive-behavioural therapy in anxiety disorder ( 26989097)	Attention deficit hyperactivity disorder (inattention symptoms) ( 32595297)
Interacting Genes		32 interacting genes: ACAN ATN1 BCAN COL18A1 COL4A1 COL4A2 COL4A3 COL4A4 COL4A5 COL4A6 COL8A1 ELN ERCC6 FBN1 FBXW5 FN1 HOXA1 HSD3B7 HSPG2 ITGB3 JOSD1 LAMA1 LAMA5 LAMC2 LCE3D NID1 NUFIP2 OTX1 PRELP VCAN ZNF408 ZNF414	6 interacting genes: COL1A1 COL2A1 FBLN2 FN1 HSPG2 NID1
Entrez ID		2199	5549
HPRD ID		00630	03556
Ensembl ID		ENSG00000163520	ENSG00000188783
Uniprot IDs		P98095 Q86V58	P51888
PDB IDs
Enriched GO Terms of Interacting Partners?		Basement Membrane Extracellular Matrix Structural Constituent Extracellular Matrix Collagen Type IV Trimer Extracellular Matrix Structural Constituent Conferring Tensile Strength Collagen Trimer Endoplasmic Reticulum Lumen Collagen-activated Tyrosine Kinase Receptor Signaling Pathway Extracellular Region Collagen-activated Signaling Pathway Cell Adhesion Extracellular Matrix Structural Constituent Conferring Compression Resistance Developmental Process Extracellular Structure Organization Extracellular Matrix Organization Integrin Binding Lysosomal Lumen Perineuronal Net Glomerular Basement Membrane Development Skeletal System Development Golgi Lumen Angiogenesis System Development Hyaluronic Acid Binding Extracellular Matrix Binding Endodermal Cell Differentiation Retinal Blood Vessel Morphogenesis Extracellular Space Substrate Adhesion-dependent Cell Spreading Regulation Of Basement Membrane Organization Positive Regulation Of Cell-substrate Adhesion Anatomical Structure Formation Involved In Morphogenesis Blood Coagulation, Fibrin Clot Formation Protein Complex Involved In Cell-matrix Adhesion Retina Vasculature Morphogenesis In Camera-type Eye Extracellular Matrix Constituent Conferring Elasticity Central Nervous System Development Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Cellular Response To Insulin-like Growth Factor Stimulus Cell-substrate Adhesion Heparin Binding Branching Involved In Salivary Gland Morphogenesis Proteoglycan Binding Positive Regulation Of Integrin-mediated Signaling Pathway Regulation Of Extracellular Matrix Organization Response To Activity Protein Activation Cascade Regulation Of Cell Adhesion Regulation Of Cell-substrate Adhesion Regulation Of Integrin-mediated Signaling Pathway	Extracellular Matrix Structural Constituent Extracellular Matrix Proteoglycan Binding Basement Membrane Regulation Of Cell-substrate Adhesion Regulation Of Cell Adhesion Fibrillar Collagen Trimer Platelet-derived Growth Factor Binding Positive Regulation Of Cell-substrate Adhesion Extracellular Region Cartilage Development Involved In Endochondral Bone Morphogenesis Endochondral Ossification Extracellular Matrix Binding Extracellular Matrix Organization Extracellular Matrix Structural Constituent Conferring Tensile Strength Extracellular Structure Organization Anatomical Structure Formation Involved In Morphogenesis Endoplasmic Reticulum Lumen Collagen Fibril Organization Collagen Binding Cellular Response To Vitamin E Collagen Trimer System Development Cartilage Development Collagen Type I Trimer Protease Binding Cellular Response To Fluoride Positive Regulation Of Cell Adhesion Cell-matrix Adhesion Collagen V Binding Skeletal System Morphogenesis Ossification Collagen Type II Trimer Negative Regulation Of Monocyte Activation Positive Regulation Of Substrate-dependent Cell Migration, Cell Attachment To Substrate CAF-1 Complex Animal Organ Development Calcium Ion Binding Response To Fluoride Sensory Perception Of Mechanical Stimulus Sensory Perception Of Sound Extracellular Space Calcium-independent Cell-matrix Adhesion Integrin Binding Cell-substrate Adhesion Collagen Type XI Trimer Anterior Head Development Intramembranous Ossification Visual Perception Skeletal System Development
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