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FBLN2 and FBN1
Number of citations of the paper that reports this interaction (PubMedID
8702639
)
0
Data Source:
BioGRID
(pull down)
HPRD
(in vivo)
FBLN2
FBN1
Description
fibulin 2
fibrillin 1
Image
No pdb structure
GO Annotations
Cellular Component
Extracellular Region
Extracellular Matrix
Extracellular Vesicle
Microfibril
Extracellular Region
Basement Membrane
Extracellular Space
Endoplasmic Reticulum Lumen
Extracellular Matrix
Molecular Function
Extracellular Matrix Structural Constituent
Calcium Ion Binding
Protein Binding
Extracellular Matrix Constituent Conferring Elasticity
Extracellular Matrix Binding
Integrin Binding
Hormone Activity
Extracellular Matrix Structural Constituent
Calcium Ion Binding
Protein Binding
Heparin Binding
Extracellular Matrix Constituent Conferring Elasticity
Identical Protein Binding
Protein-containing Complex Binding
Biological Process
Positive Regulation Of Cell-substrate Adhesion
Skeletal System Development
Metanephros Development
Kidney Development
Glucose Metabolic Process
Signal Transduction
Heart Development
Gene Expression
Protein Kinase A Signaling
Lung Development
Positive Regulation Of Appetite
Cell Adhesion Mediated By Integrin
Activation Of Protein Kinase A Activity
Sequestering Of BMP In Extracellular Matrix
Sequestering Of TGFbeta In Extracellular Matrix
Glucose Homeostasis
Camera-type Eye Development
Negative Regulation Of Osteoclast Differentiation
Embryonic Eye Morphogenesis
Post-embryonic Eye Morphogenesis
Lung Alveolus Development
Cellular Response To Transforming Growth Factor Beta Stimulus
Cellular Response To Insulin-like Growth Factor Stimulus
Negative Regulation Of Osteoclast Development
Pathways
Molecules associated with elastic fibres
Molecules associated with elastic fibres
Degradation of the extracellular matrix
Degradation of the extracellular matrix
Elastic fibre formation
Molecules associated with elastic fibres
Molecules associated with elastic fibres
Integrin cell surface interactions
TGF-beta receptor signaling activates SMADs
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Post-translational protein phosphorylation
Drugs
Diseases
Geleophysic dysplasia
Weill-Marchesani syndrome, including: Weill-Marchesani syndrome; Weill-Marchesani-like syndrome
Shprintzen-Goldberg syndrome
Ectopia lentis
MASS phenotype
Marfan syndrome, including: Marfan syndrome (MFS); Neonatal MFS; Atypically severe MFS; New variant of MFS
GWAS
Appendicular lean mass (
33097823
)
Bipolar disorder with mood-incongruent psychosis (
23092984
)
Body mass index (
26426971
)
Hip circumference adjusted for BMI (
34021172
)
Response to cognitive-behavioural therapy in anxiety disorder (
26989097
)
Breast cancer (
17903305
)
Central corneal thickness (
32528159
29760442
)
Height (
32499652
31562340
)
Hepcidin/ferritin ratio (
27846281
)
Hip circumference adjusted for BMI (
34021172
28552196
)
Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy) (
27418160
)
Intraocular pressure (
29617998
)
Macular thickness (
30535121
)
Pulse pressure (
28739976
30578418
27841878
)
Pulse pressure x alcohol consumption interaction (2df test) (
29912962
)
Refractive error (
32231278
)
Spherical equivalent (joint analysis main effects and education interaction) (
27020472
)
Spherical equivalent or myopia (age of diagnosis) (
29808027
)
Spontaneous coronary artery dissection (
32374345
)
Systolic blood pressure (
27841878
30578418
)
Systolic blood pressure x alcohol consumption interaction (2df test) (
29912962
)
Thoracic aortic aneurysms and dissections (
21909107
)
Waist circumference adjusted for body mass index (
34021172
)
Interacting Genes
32 interacting genes:
ACAN
ATN1
BCAN
COL18A1
COL4A1
COL4A2
COL4A3
COL4A4
COL4A5
COL4A6
COL8A1
ELN
ERCC6
FBN1
FBXW5
FN1
HOXA1
HSD3B7
HSPG2
ITGB3
JOSD1
LAMA1
LAMA5
LAMC2
LCE3D
NID1
NUFIP2
OTX1
PRELP
VCAN
ZNF408
ZNF414
18 interacting genes:
ATXN7
CALR
DCN
DYRK1A
ELN
FBLN2
FBN2
GET4
HGS
HOXA1
HSPG2
LTBP1
MFAP2
MFAP5
MYOC
SGTB
SPRY2
VCAN
Entrez ID
2199
2200
HPRD ID
00630
00618
Ensembl ID
ENSG00000163520
ENSG00000166147
Uniprot IDs
P98095
Q86V58
P35555
PDB IDs
1APJ
1EMN
1EMO
1LMJ
1UZJ
1UZK
1UZP
1UZQ
2M74
2W86
5MS9
Enriched GO Terms of Interacting Partners
?
Basement Membrane
Extracellular Matrix Structural Constituent
Extracellular Matrix
Collagen Type IV Trimer
Extracellular Matrix Structural Constituent Conferring Tensile Strength
Collagen Trimer
Endoplasmic Reticulum Lumen
Collagen-activated Tyrosine Kinase Receptor Signaling Pathway
Extracellular Region
Collagen-activated Signaling Pathway
Cell Adhesion
Extracellular Matrix Structural Constituent Conferring Compression Resistance
Developmental Process
Extracellular Structure Organization
Extracellular Matrix Organization
Integrin Binding
Lysosomal Lumen
Perineuronal Net
Glomerular Basement Membrane Development
Skeletal System Development
Golgi Lumen
Angiogenesis
System Development
Hyaluronic Acid Binding
Extracellular Matrix Binding
Endodermal Cell Differentiation
Retinal Blood Vessel Morphogenesis
Extracellular Space
Substrate Adhesion-dependent Cell Spreading
Regulation Of Basement Membrane Organization
Positive Regulation Of Cell-substrate Adhesion
Anatomical Structure Formation Involved In Morphogenesis
Blood Coagulation, Fibrin Clot Formation
Protein Complex Involved In Cell-matrix Adhesion
Retina Vasculature Morphogenesis In Camera-type Eye
Extracellular Matrix Constituent Conferring Elasticity
Central Nervous System Development
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Cellular Response To Insulin-like Growth Factor Stimulus
Cell-substrate Adhesion
Heparin Binding
Branching Involved In Salivary Gland Morphogenesis
Proteoglycan Binding
Positive Regulation Of Integrin-mediated Signaling Pathway
Regulation Of Extracellular Matrix Organization
Response To Activity
Protein Activation Cascade
Regulation Of Cell Adhesion
Regulation Of Cell-substrate Adhesion
Regulation Of Integrin-mediated Signaling Pathway
Microfibril
Extracellular Matrix
Extracellular Matrix Structural Constituent
Extracellular Matrix Constituent Conferring Elasticity
Extracellular Matrix Structural Constituent Conferring Compression Resistance
Negative Regulation Of Supramolecular Fiber Organization
Sequestering Of TGFbeta In Extracellular Matrix
Embryonic Eye Morphogenesis
Regulation Of Cellular Response To Growth Factor Stimulus
Extracellular Matrix Binding
Protein-folding Chaperone Binding
Extracellular Region
Regulation Of Supramolecular Fiber Organization
Negative Regulation Of Vasculature Development
Negative Regulation Of Angiogenesis
Positive Regulation Of Mitochondrial Depolarization
Negative Regulation Of Cytoskeleton Organization
Sequestering Of Extracellular Ligand From Receptor
Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Eye Morphogenesis
Animal Organ Morphogenesis
Extracellular Negative Regulation Of Signal Transduction
Post-translational Protein Targeting To Endoplasmic Reticulum Membrane
Sensory Organ Morphogenesis
Positive Regulation Of Membrane Depolarization
Calcium Ion Binding
Negative Regulation Of Vascular Endothelial Growth Factor Signaling Pathway
Maintenance Of Location
Regulation Of Trophoblast Cell Migration
Negative Regulation Of Cellular Response To Vascular Endothelial Growth Factor Stimulus
Lysosomal Lumen
Embryonic Morphogenesis
Golgi Lumen
Regulation Of Mitochondrial Depolarization
Glycosaminoglycan Binding
Negative Regulation Of Cellular Component Organization
Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Negative Regulation Of Signal Transduction
Positive Regulation Of Cell-substrate Adhesion
Negative Regulation Of Cellular Response To Growth Factor Stimulus
Embryonic Organ Morphogenesis
Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway
Fibronectin Binding
Protein Targeting To ER
Regulation Of Cytoskeleton Organization
Establishment Of Protein Localization To Endoplasmic Reticulum
Regulation Of Vascular Endothelial Growth Factor Signaling Pathway
Negative Regulation Of Cell Communication
Negative Regulation Of Signaling
Regulation Of Protein Metabolic Process
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Tagcloud (Intersection)
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