FBLN2 and FBN1

Number of citations: 0 (PubMedID 8702639)
Data Source: BioGRID (pull down), HPRD (in vivo)

		FBLN2	FBN1
Name		fibulin 2	fibrillin 1
Structure		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Matrix Extracellular Vesicle	Microfibril Extracellular Region Basement Membrane Extracellular Space Endoplasmic Reticulum Lumen Extracellular Matrix
	Molecular Function	Extracellular Matrix Structural Constituent Calcium Ion Binding Protein Binding Extracellular Matrix Constituent Conferring Elasticity Extracellular Matrix Binding	Integrin Binding Hormone Activity Extracellular Matrix Structural Constituent Calcium Ion Binding Protein Binding Heparin Binding Extracellular Matrix Constituent Conferring Elasticity Identical Protein Binding Protein-containing Complex Binding
	Biological Process	Positive Regulation Of Cell-substrate Adhesion	Skeletal System Development Metanephros Development Kidney Development Glucose Metabolic Process Signal Transduction Heart Development Gene Expression Protein Kinase A Signaling Lung Development Positive Regulation Of Appetite Cell Adhesion Mediated By Integrin Activation Of Protein Kinase A Activity Sequestering Of BMP In Extracellular Matrix Sequestering Of TGFbeta In Extracellular Matrix Glucose Homeostasis Camera-type Eye Development Negative Regulation Of Osteoclast Differentiation Embryonic Eye Morphogenesis Post-embryonic Eye Morphogenesis Lung Alveolus Development Cellular Response To Transforming Growth Factor Beta Stimulus Cellular Response To Insulin-like Growth Factor Stimulus Negative Regulation Of Osteoclast Development
Pathways		Molecules associated with elastic fibres Molecules associated with elastic fibres	Degradation of the extracellular matrix Degradation of the extracellular matrix Elastic fibre formation Molecules associated with elastic fibres Molecules associated with elastic fibres Integrin cell surface interactions TGF-beta receptor signaling activates SMADs Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation
Diseases		None	Geleophysic dysplasia Weill-Marchesani syndrome, including: Weill-Marchesani syndrome; Weill-Marchesani-like syndrome Shprintzen-Goldberg syndrome Ectopia lentis MASS phenotype Marfan syndrome, including: Marfan syndrome (MFS); Neonatal MFS; Atypically severe MFS; New variant of MFS
GWAS		Appendicular lean mass ( 33097823 ) Bipolar disorder with mood-incongruent psychosis ( 23092984 ) Body mass index ( 26426971 ) Hip circumference adjusted for BMI ( 34021172 ) Response to cognitive-behavioural therapy in anxiety disorder ( 26989097 )	Breast cancer ( 17903305 ) Central corneal thickness ( 32528159 29760442 ) Height ( 32499652 31562340 ) Hepcidin/ferritin ratio ( 27846281 ) Hip circumference adjusted for BMI ( 34021172 28552196 ) Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy) ( 27418160 ) Intraocular pressure ( 29617998 ) Macular thickness ( 30535121 ) Pulse pressure ( 28739976 30578418 27841878 ) Pulse pressure x alcohol consumption interaction (2df test) ( 29912962 ) Refractive error ( 32231278 ) Spherical equivalent (joint analysis main effects and education interaction) ( 27020472 ) Spherical equivalent or myopia (age of diagnosis) ( 29808027 ) Spontaneous coronary artery dissection ( 32374345 ) Systolic blood pressure ( 27841878 30578418 ) Systolic blood pressure x alcohol consumption interaction (2df test) ( 29912962 ) Thoracic aortic aneurysms and dissections ( 21909107 ) Waist circumference adjusted for body mass index ( 34021172 )
Interacting Genes		32 interacting genes: ACAN ATN1 BCAN COL18A1 COL4A1 COL4A2 COL4A3 COL4A4 COL4A5 COL4A6 COL8A1 ELN ERCC6 FBN1 FBXW5 FN1 HOXA1 HSD3B7 HSPG2 ITGB3 JOSD1 LAMA1 LAMA5 LAMC2 LCE3D NID1 NUFIP2 OTX1 PRELP VCAN ZNF408 ZNF414	18 interacting genes: ATXN7 CALR DCN DYRK1A ELN FBLN2 FBN2 GET4 HGS HOXA1 HSPG2 LTBP1 MFAP2 MFAP5 MYOC SGTB SPRY2 VCAN
Entrez ID		2199	2200
HPRD ID		00630	00618
Ensembl ID		ENSG00000163520	ENSG00000166147
Uniprot IDs		P98095 Q86V58	P35555
PDB IDs		Not available	1APJ 1EMN 1EMO 1LMJ 1UZJ 1UZK 1UZP 1UZQ 2M74 2W86 5MS9
GO Terms Enriched among Interactors		Basement Membrane Extracellular Matrix Structural Constituent Extracellular Matrix Collagen Type IV Trimer Extracellular Matrix Structural Constituent Conferring Tensile Strength Collagen Trimer Endoplasmic Reticulum Lumen Collagen-activated Tyrosine Kinase Receptor Signaling Pathway Extracellular Region Collagen-activated Signaling Pathway Cell Adhesion Extracellular Matrix Structural Constituent Conferring Compression Resistance Developmental Process Extracellular Structure Organization Extracellular Matrix Organization Integrin Binding Lysosomal Lumen Perineuronal Net Glomerular Basement Membrane Development Skeletal System Development Golgi Lumen Angiogenesis System Development Hyaluronic Acid Binding Extracellular Matrix Binding Endodermal Cell Differentiation Retinal Blood Vessel Morphogenesis Extracellular Space Substrate Adhesion-dependent Cell Spreading Regulation Of Basement Membrane Organization Positive Regulation Of Cell-substrate Adhesion Anatomical Structure Formation Involved In Morphogenesis Blood Coagulation, Fibrin Clot Formation Protein Complex Involved In Cell-matrix Adhesion Retina Vasculature Morphogenesis In Camera-type Eye Extracellular Matrix Constituent Conferring Elasticity Central Nervous System Development Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Cellular Response To Insulin-like Growth Factor Stimulus Cell-substrate Adhesion Heparin Binding Branching Involved In Salivary Gland Morphogenesis Proteoglycan Binding Positive Regulation Of Integrin-mediated Signaling Pathway Regulation Of Extracellular Matrix Organization Response To Activity Protein Activation Cascade Regulation Of Cell Adhesion Regulation Of Cell-substrate Adhesion Regulation Of Integrin-mediated Signaling Pathway	Microfibril Extracellular Matrix Extracellular Matrix Structural Constituent Extracellular Matrix Constituent Conferring Elasticity Extracellular Matrix Structural Constituent Conferring Compression Resistance Negative Regulation Of Supramolecular Fiber Organization Sequestering Of TGFbeta In Extracellular Matrix Embryonic Eye Morphogenesis Regulation Of Cellular Response To Growth Factor Stimulus Extracellular Matrix Binding Protein-folding Chaperone Binding Extracellular Region Regulation Of Supramolecular Fiber Organization Negative Regulation Of Vasculature Development Negative Regulation Of Angiogenesis Positive Regulation Of Mitochondrial Depolarization Negative Regulation Of Cytoskeleton Organization Sequestering Of Extracellular Ligand From Receptor Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Eye Morphogenesis Animal Organ Morphogenesis Extracellular Negative Regulation Of Signal Transduction Post-translational Protein Targeting To Endoplasmic Reticulum Membrane Sensory Organ Morphogenesis Positive Regulation Of Membrane Depolarization Calcium Ion Binding Negative Regulation Of Vascular Endothelial Growth Factor Signaling Pathway Maintenance Of Location Regulation Of Trophoblast Cell Migration Negative Regulation Of Cellular Response To Vascular Endothelial Growth Factor Stimulus Lysosomal Lumen Embryonic Morphogenesis Golgi Lumen Regulation Of Mitochondrial Depolarization Glycosaminoglycan Binding Negative Regulation Of Cellular Component Organization Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Signal Transduction Positive Regulation Of Cell-substrate Adhesion Negative Regulation Of Cellular Response To Growth Factor Stimulus Embryonic Organ Morphogenesis Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Fibronectin Binding Protein Targeting To ER Regulation Of Cytoskeleton Organization Establishment Of Protein Localization To Endoplasmic Reticulum Regulation Of Vascular Endothelial Growth Factor Signaling Pathway Negative Regulation Of Cell Communication Negative Regulation Of Signaling Regulation Of Protein Metabolic Process