FBLN2 and JOSD1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		FBLN2	JOSD1
Description		fibulin 2	Josephin domain containing 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Matrix Extracellular Vesicle	Cytoplasm Cytosol Plasma Membrane Membrane
	Molecular Function	Extracellular Matrix Structural Constituent Calcium Ion Binding Protein Binding Extracellular Matrix Constituent Conferring Elasticity Extracellular Matrix Binding	Cysteine-type Deubiquitinase Activity Protein Binding Peptidase Activity Hydrolase Activity Deubiquitinase Activity
	Biological Process	Positive Regulation Of Cell-substrate Adhesion	Proteolysis Endocytosis Protein Deubiquitination Membrane Biogenesis Cell Motility Membrane Organization
Pathways		Molecules associated with elastic fibres Molecules associated with elastic fibres	Josephin domain DUBs
Drugs
Diseases
GWAS		Appendicular lean mass ( 33097823) Bipolar disorder with mood-incongruent psychosis ( 23092984) Body mass index ( 26426971) Hip circumference adjusted for BMI ( 34021172) Response to cognitive-behavioural therapy in anxiety disorder ( 26989097)	Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Plateletcrit ( 32888494) Resting heart rate ( 27798624) Sleep duration ( 30846698)
Interacting Genes		32 interacting genes: ACAN ATN1 BCAN COL18A1 COL4A1 COL4A2 COL4A3 COL4A4 COL4A5 COL4A6 COL8A1 ELN ERCC6 FBN1 FBXW5 FN1 HOXA1 HSD3B7 HSPG2 ITGB3 JOSD1 LAMA1 LAMA5 LAMC2 LCE3D NID1 NUFIP2 OTX1 PRELP VCAN ZNF408 ZNF414	38 interacting genes: ADAMTSL4 CARD10 CYSRT1 FBLN2 KRT27 KRT31 KRT34 KRT40 KRT86 KRTAP1-1 KRTAP1-3 KRTAP10-3 KRTAP10-4 KRTAP10-8 KRTAP12-3 KRTAP2-3 KRTAP2-4 KRTAP5-9 KRTAP9-2 KRTAP9-3 LNX1 MDFI MID2 MTUS2 NBPF19 NOTCH2NLA PJA1 STUB1 TGM1 TRAF1 TRIM23 TRIM27 TRIM54 TRIM63 UBC USP15 USP21 USP28
Entrez ID		2199	9929
HPRD ID		00630	08823
Ensembl ID		ENSG00000163520	ENSG00000100221
Uniprot IDs		P98095 Q86V58	Q15040
PDB IDs
Enriched GO Terms of Interacting Partners?		Basement Membrane Extracellular Matrix Structural Constituent Extracellular Matrix Collagen Type IV Trimer Extracellular Matrix Structural Constituent Conferring Tensile Strength Collagen Trimer Endoplasmic Reticulum Lumen Collagen-activated Tyrosine Kinase Receptor Signaling Pathway Extracellular Region Collagen-activated Signaling Pathway Cell Adhesion Extracellular Matrix Structural Constituent Conferring Compression Resistance Developmental Process Extracellular Structure Organization Extracellular Matrix Organization Integrin Binding Lysosomal Lumen Perineuronal Net Glomerular Basement Membrane Development Skeletal System Development Golgi Lumen Angiogenesis System Development Hyaluronic Acid Binding Extracellular Matrix Binding Endodermal Cell Differentiation Retinal Blood Vessel Morphogenesis Extracellular Space Substrate Adhesion-dependent Cell Spreading Regulation Of Basement Membrane Organization Positive Regulation Of Cell-substrate Adhesion Anatomical Structure Formation Involved In Morphogenesis Blood Coagulation, Fibrin Clot Formation Protein Complex Involved In Cell-matrix Adhesion Retina Vasculature Morphogenesis In Camera-type Eye Extracellular Matrix Constituent Conferring Elasticity Central Nervous System Development Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Cellular Response To Insulin-like Growth Factor Stimulus Cell-substrate Adhesion Heparin Binding Branching Involved In Salivary Gland Morphogenesis Proteoglycan Binding Positive Regulation Of Integrin-mediated Signaling Pathway Regulation Of Extracellular Matrix Organization Response To Activity Protein Activation Cascade Regulation Of Cell Adhesion Regulation Of Cell-substrate Adhesion Regulation Of Integrin-mediated Signaling Pathway	Keratin Filament Intermediate Filament Structural Constituent Of Skin Epidermis Identical Protein Binding Intermediate Filament Organization Ubiquitin Protein Ligase Activity Post-translational Protein Modification Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Protein Ubiquitination Protein Modification By Small Protein Conjugation Cytosol Protein Modification Process Ubiquitin-protein Transferase Activity Epidermis Development Negative Regulation Of Viral Transcription Positive Regulation Of Autophagy Suppression Of Viral Release By Host Structural Molecule Activity Supramolecular Fiber Organization Regulation Of Viral Transcription Microtubule Cysteine-type Deubiquitinase Activity Protein Deubiquitination Deubiquitinase Activity
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