FBLN2 and LAMC2

Number of citations of the paper that reports this interaction (PMID 11733994)
25

Data Source:
HPRD (in vitro)

		FBLN2	LAMC2
Gene Name		fibulin 2	laminin, gamma 2
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Proteinaceous Extracellular Matrix Extracellular Matrix Vesicle Extracellular Vesicular Exosome	Extracellular Region Laminin-2 Complex Laminin-5 Complex Extracellular Space Cell Cortex Membrane Perinuclear Region Of Cytoplasm
	Molecular Function	Extracellular Matrix Structural Constituent Calcium Ion Binding Extracellular Matrix Binding	Heparin Binding
	Biological Process	Positive Regulation Of Cell-substrate Adhesion Extracellular Matrix Organization	Cell Adhesion Epidermis Development Extracellular Matrix Disassembly Extracellular Matrix Organization Hemidesmosome Assembly Cell Junction Assembly
Pathways		Molecules associated with elastic fibres Elastic fibre formation	Cell junction organization Type I hemidesmosome assembly Collagen formation Laminin interactions Anchoring fibril formation Non-integrin membrane-ECM interactions Degradation of the extracellular matrix Assembly of collagen fibrils and other multimeric structures
Drugs
Diseases
GWAS		Bipolar disorder (mood-incongruent) ( 23092984)	Coronary heart disease ( 21347282) Systemic lupus erythematosus ( 21408207)
Protein-Protein Interactions		22 interactors: ACAN ATN1 BCAN COL18A1 COL4A1 COL4A2 COL4A3 COL4A4 COL4A5 COL4A6 ELN FBN1 FN1 HSPG2 ITGB3 LAMA1 LAMA5 LAMC2 NID1 PRELP VCAN ZNF408	6 interactors: BMP1 COL7A1 FBLN2 LAMB3 NID1 SLA2
Entrez ID		2199	3918
HPRD ID		00630	01031
Ensembl ID		ENSG00000163520	ENSG00000058085
Uniprot IDs		F5H1F3 P98095 Q86V58 Q9Y3V7	Q13753
PDB IDs
Enriched GO Terms of Interacting Partners?		Extracellular Matrix Disassembly Extracellular Matrix Organization Extracellular Structure Organization Collagen Catabolic Process Collagen Metabolic Process Multicellular Organismal Macromolecule Metabolic Process Multicellular Organismal Metabolic Process Anatomical Structure Development System Development Developmental Process Multicellular Organismal Development Cell Adhesion Cell Morphogenesis Involved In Differentiation Glycosaminoglycan Catabolic Process Cardiovascular System Development Blood Vessel Morphogenesis Locomotion Catabolic Process Blood Vessel Development Cell Morphogenesis Nervous System Development Angiogenesis Vasculature Development Movement Of Cell Or Subcellular Component Anatomical Structure Morphogenesis Glycosaminoglycan Biosynthetic Process Axon Guidance Tissue Development Cell-substrate Junction Assembly Cell Development Organ Development Axonogenesis Glomerular Basement Membrane Development Renal System Development Cell Projection Morphogenesis Glycosaminoglycan Metabolic Process Axon Development Cell Part Morphogenesis Cell Morphogenesis Involved In Neuron Differentiation Chemotaxis Urogenital System Development Pathogenesis Neuron Projection Morphogenesis Cell Differentiation Proteoglycan Metabolic Process Cell Projection Organization Neuron Projection Development Retinal Blood Vessel Morphogenesis Kidney Development Neurogenesis	Extracellular Matrix Disassembly Extracellular Matrix Organization Extracellular Structure Organization Endodermal Cell Differentiation Endoderm Formation Cell Adhesion Endoderm Development Positive Regulation Of Cell-substrate Adhesion Formation Of Primary Germ Layer Gastrulation Regulation Of Cell-substrate Adhesion Epidermis Development Negative Regulation Of Calcium-mediated Signaling Hemidesmosome Assembly Positive Regulation Of Cell Adhesion Glomerular Basement Membrane Development Basement Membrane Organization Cartilage Condensation Tissue Development
Tagcloud ?		3p 3p24 anonymous arrayed candidate chromosomal closely colocation d3s1585 excluded fibulin generated intragenic linkage locus lod map marfan marker markers matrix mfs2 p25 placed point polymorphic polymorphisms scores sequencing	accumulating adhesion alpha3beta1 alpha6beta4 anticancer attractive autocrine barrier basement biomarker countries crucial drive egfrs indicates influences inhibiting integrins lamina laminin laminins layers mechanical membranes migration morbidity network transformed tumorigenesis
Tagcloud (Difference) ?		3p 3p24 anonymous arrayed candidate chromosomal closely colocation d3s1585 excluded fibulin generated intragenic linkage locus lod map marfan marker markers matrix mfs2 p25 placed point polymorphic polymorphisms scores sequencing	accumulating adhesion alpha3beta1 alpha6beta4 anticancer attractive autocrine barrier basement biomarker countries crucial drive egfrs indicates influences inhibiting integrins lamina laminin laminins layers mechanical membranes migration morbidity network transformed tumorigenesis
Tagcloud (Intersection) ?