SWSAP1 and A2M

Number of citations of the paper that reports this interaction (PubMedID 21163940)
58

Data Source:
BioGRID (two hybrid)

		SWSAP1	A2M
Description		SWIM-type zinc finger 7 associated protein 1	alpha-2-macroglobulin
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Shu Complex	Extracellular Region Extracellular Space Extracellular Matrix Platelet Alpha Granule Lumen Extracellular Exosome Blood Microparticle
	Molecular Function	DNA Binding Single-stranded DNA Binding Protein Binding ATP Hydrolysis Activity	Protease Binding Endopeptidase Inhibitor Activity Serine-type Endopeptidase Inhibitor Activity Signaling Receptor Binding Protein Binding Growth Factor Binding Enzyme Binding Interleukin-8 Binding Interleukin-1 Binding Peptidase Inhibitor Activity Tumor Necrosis Factor Binding Calcium-dependent Protein Binding
	Biological Process	Double-strand Break Repair Via Homologous Recombination DNA Repair DNA Recombination DNA Damage Response Protein Stabilization	Negative Regulation Of Complement Activation, Lectin Pathway Stem Cell Differentiation
Pathways			Platelet degranulation Intrinsic Pathway of Fibrin Clot Formation Degradation of the extracellular matrix HDL assembly
Drugs			Becaplermin Cisplatin Bacitracin Zinc Ocriplasmin Silver Zinc acetate Zinc chloride Zinc sulfate, unspecified form
Diseases
GWAS		Coronary artery disease ( 29212778)	Refractive error ( 32231278)
Interacting Genes		8 interacting genes: A2M EPM2AIP1 RAD51 RAD51B RAD51C RAD51D SPG21 XRCC3	99 interacting genes: ACTB ADAM19 ADAMTS1 AMBP ANXA6 ANXA7 AP1M2 APOE APP ATF7IP ATP1A1 B2M C11orf58 CDC37 CDC42 CDK2AP2 CDKN1A CELA1 CPB2 CTSB CTSE CYP2C18 CYP2C8 DNAJB1 ECSIT EGLN2 ELAVL3 ENO2 EVI5L EXOSC1 FARSA FBXL12 FBXW4 FIS1 GCDH GEM GRB2 H2AX HMOX2 HSP90AA1 HSPA5 HSPB2 IFIT3 IFIT5 IGSF8 IL10 IL1B IL4 KLK1 KLK13 KLK2 KLK3 LCAT LEP LINC02582 LONP1 LRP1 LYZ MAST1 MLST8 MMP2 MYOC NCDN NGF NOS3 NUDT21 OGA PAEP PAXIP1 PDGFA PDGFB PRAM1 PRDX2 RAB3A RAD23A RAP1B RETN RHEB RNF32 RPP14 SEPTIN8 SHBG SLC6A4 SMN1 STAMBPL1 SWSAP1 TGFBI TGIF1 TGM2 TK1 TNFRSF14 TRAPPC5 TSC22D1 TTR TUBA1B TYRO3 UFD1 UMPS USP40
Entrez ID		126074	2
HPRD ID		08179	00072
Ensembl ID		ENSG00000173928	ENSG00000175899
Uniprot IDs		A0A6I8PRB2 Q6NVH7	P01023
PDB IDs			1BV8 2P9R 6TAV 7O7L 7O7M 7O7N 7O7O 7O7P 7O7Q 7O7R 7O7S 7VON 7VOO
Enriched GO Terms of Interacting Partners?		ATP-dependent DNA Damage Sensor Activity Telomere Maintenance Via Recombination Four-way Junction DNA Binding Mitotic Recombination Rad51B-Rad51C-Rad51D-XRCC2 Complex Reciprocal Meiotic Recombination Replication Fork Double-strand Break Repair Via Homologous Recombination Homologous Recombination Recombinational Repair Double-strand Break Repair DNA Recombination Telomere Maintenance Rad51C-XRCC3 Complex Telomere Organization ATP-dependent Activity, Acting On DNA Interstrand Cross-link Repair DNA Repair DNA Strand Invasion DNA Recombinase Assembly Crossover Junction DNA Endonuclease Activity DNA Metabolic Process DNA Damage Response Chromosome Organization Single-stranded DNA Binding Regulation Of Cell Cycle Phase Transition Regulation Of Cell Cycle Chromosome, Telomeric Region Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Positive Regulation Of Cell Cycle G2/M Phase Transition Meiosis I ATP Binding Positive Regulation Of Cell Cycle Process Regulation Of Cell Cycle Process Cellular Response To Stress Positive Regulation Of Cell Cycle Regulation Of Mitotic Cell Cycle Phase Transition Nucleotide Binding Meiosis I Cell Cycle Process Response To Glucoside Female Meiosis Sister Chromatid Cohesion Meiotic Nuclear Division Negative Regulation Of Complement Activation, Lectin Pathway Mitotic Recombination-dependent Replication Fork Processing Nuclear Division Macromolecule Metabolic Process DNA Strand Exchange Activity Presynaptic Intermediate Filament Cytoskeleton Nucleic Acid Metabolic Process Positive Regulation Of Mitotic Cell Cycle Phase Transition	Negative Regulation Of Multicellular Organismal Process Extracellular Exosome Extracellular Space Peptidase Activity Ovulation From Ovarian Follicle Regulation Of Cell Activation Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Hydrolase Activity Ovulation Regulation Of Multicellular Organismal Process Response To Stress Regulation Of Blood Coagulation Negative Regulation Of Platelet Activation Regulation Of Hemostasis Extracellular Region Regulation Of Amyloid-beta Clearance Positive Regulation Of Cell Adhesion Smooth Muscle Adaptation Regulation Of Programmed Cell Death Regulation Of Immune Response Negative Regulation Of Blood Coagulation Negative Regulation Of Hemostasis Positive Regulation Of Amyloid-beta Clearance Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Proteolysis Negative Regulation Of Coagulation Regulation Of Cell Adhesion Regulation Of Biological Quality Regulation Of Membrane Protein Ectodomain Proteolysis Regulation Of Apoptotic Process Positive Regulation Of Cell Activation Identical Protein Binding Positive Regulation Of Protein Metabolic Process Protein Refolding Positive Regulation Of Cell Migration Positive Regulation Of Multicellular Organismal Process Protein Metabolic Process Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Lymphocyte Activation Regulation Of Transport Melanosome Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Smooth Muscle Cell Proliferation Serine-type Endopeptidase Activity Positive Regulation Of Cell Motility Extracellular Matrix Lipoprotein Particle Platelet-derived Growth Factor Complex Negative Regulation Of Phosphatidylinositol Biosynthetic Process Regulation Of Nitric Oxide Metabolic Process
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