SWSAP1 and RAD51C

Number of citations of the paper that reports this interaction (PubMedID 21965664)
23

Data Source:
BioGRID (affinity chromatography technology, pull down)

		SWSAP1	RAD51C
Description		SWIM-type zinc finger 7 associated protein 1	RAD51 paralog C
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Shu Complex	Nucleus Nucleoplasm Replication Fork Cytoplasm Mitochondrion Cytosol Cell Junction Rad51B-Rad51C-Rad51D-XRCC2 Complex Rad51C-XRCC3 Complex Perinuclear Region Of Cytoplasm
	Molecular Function	DNA Binding Single-stranded DNA Binding Protein Binding ATP Hydrolysis Activity	Nucleotide Binding Four-way Junction DNA Binding DNA Binding Protein Binding ATP Binding Crossover Junction DNA Endonuclease Activity ATP-dependent DNA Damage Sensor Activity
	Biological Process	Double-strand Break Repair Via Homologous Recombination DNA Repair DNA Recombination DNA Damage Response Protein Stabilization	Meiotic DNA Recombinase Assembly Telomere Maintenance Via Recombination Double-strand Break Repair Via Homologous Recombination DNA Repair DNA Recombination DNA Damage Response Sister Chromatid Cohesion Female Meiosis Sister Chromatid Cohesion Reciprocal Meiotic Recombination Male Meiosis I Spermatogenesis Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle
Pathways			HDR through Homologous Recombination (HRR) Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) Resolution of D-loop Structures through Holliday Junction Intermediates Homologous DNA Pairing and Strand Exchange Presynaptic phase of homologous DNA pairing and strand exchange Meiotic recombination Defective homologous recombination repair (HRR) due to BRCA1 loss of function Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function Impaired BRCA2 binding to PALB2 Factors involved in megakaryocyte development and platelet production
Drugs
Diseases			Fanconi anemia
GWAS		Coronary artery disease ( 29212778)	Cognitive function ( 25644384) Primary tooth development (time to first tooth eruption) ( 23704328) Testicular germ cell tumor ( 23666239 23666240)
Interacting Genes		8 interacting genes: A2M EPM2AIP1 RAD51 RAD51B RAD51C RAD51D SPG21 XRCC3	8 interacting genes: APP PALB2 RAD51 RAD51B RAD51D SPG21 SWSAP1 XRCC3
Entrez ID		126074	5889
HPRD ID		08179	04143
Ensembl ID		ENSG00000173928	ENSG00000108384
Uniprot IDs		A0A6I8PRB2 Q6NVH7	A0A8V8TML8 O43502
PDB IDs			8FAZ 8GBJ 8OUY 8OUZ
Enriched GO Terms of Interacting Partners?		ATP-dependent DNA Damage Sensor Activity Telomere Maintenance Via Recombination Four-way Junction DNA Binding Mitotic Recombination Rad51B-Rad51C-Rad51D-XRCC2 Complex Reciprocal Meiotic Recombination Replication Fork Double-strand Break Repair Via Homologous Recombination Homologous Recombination Recombinational Repair Double-strand Break Repair DNA Recombination Telomere Maintenance Rad51C-XRCC3 Complex Telomere Organization ATP-dependent Activity, Acting On DNA Interstrand Cross-link Repair DNA Repair DNA Strand Invasion DNA Recombinase Assembly Crossover Junction DNA Endonuclease Activity DNA Metabolic Process DNA Damage Response Chromosome Organization Single-stranded DNA Binding Regulation Of Cell Cycle Phase Transition Regulation Of Cell Cycle Chromosome, Telomeric Region Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Positive Regulation Of Cell Cycle G2/M Phase Transition Meiosis I ATP Binding Positive Regulation Of Cell Cycle Process Regulation Of Cell Cycle Process Cellular Response To Stress Positive Regulation Of Cell Cycle Regulation Of Mitotic Cell Cycle Phase Transition Nucleotide Binding Meiosis I Cell Cycle Process Response To Glucoside Female Meiosis Sister Chromatid Cohesion Meiotic Nuclear Division Negative Regulation Of Complement Activation, Lectin Pathway Mitotic Recombination-dependent Replication Fork Processing Nuclear Division Macromolecule Metabolic Process DNA Strand Exchange Activity Presynaptic Intermediate Filament Cytoskeleton Nucleic Acid Metabolic Process Positive Regulation Of Mitotic Cell Cycle Phase Transition	Recombinational Repair Double-strand Break Repair Via Homologous Recombination ATP-dependent DNA Damage Sensor Activity Double-strand Break Repair DNA Recombination Telomere Maintenance Via Recombination DNA Repair Four-way Junction DNA Binding Mitotic Recombination Single-stranded DNA Binding Reciprocal Meiotic Recombination Replication Fork DNA Binding DNA Metabolic Process ATP-dependent Activity, Acting On DNA Developmental Growth DNA Damage Response Homologous Recombination Interstrand Cross-link Repair Rad51B-Rad51C-Rad51D-XRCC2 Complex DNA Strand Invasion Regulation Of Cell Cycle Nucleic Acid Metabolic Process Response To Stress Macromolecule Metabolic Process Telomere Maintenance Collateral Sprouting Telomere Organization Cellular Response To Stress Nucleobase-containing Compound Metabolic Process Cell Maturation Chromosome, Telomeric Region Neuron Maturation Developmental Maturation In Utero Embryonic Development Chordate Embryonic Development Reproductive Process Embryo Development Ending In Birth Or Egg Hatching Multicellular Organism Development Response To Gamma Radiation Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Response To Growth Factor Amylin Binding Positive Regulation Of Toll Signaling Pathway Regulation Of Cellular Response To X-ray Negative Regulation Of Glial Cell-derived Neurotrophic Factor Receptor Signaling Pathway Involved In Ureteric Bud Formation Type IV Hypersensitivity Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Involved In Ureteric Bud Formation
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