AEBP2 and H1-1

Number of citations of the paper that reports this interaction (PubMedID 16431907)
0

Data Source:
BioGRID (pull down)

		AEBP2	H1-1
Description		AE binding protein 2	H1.1 linker histone, cluster member
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GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm ESC/E(Z) Complex	Chromatin Nucleosome Euchromatin Nucleus Nucleoplasm Chromosome Cell Surface Vesicle
	Molecular Function	DNA Binding Transcription Coregulator Activity Protein Binding Zinc Ion Binding Metal Ion Binding	DNA Binding Double-stranded DNA Binding Protein Binding Heparin Binding Structural Constituent Of Chromatin Chromatin DNA Binding Nucleosomal DNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Organization Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II	Nucleosome Assembly Spermatogenesis Chromosome Condensation Negative Regulation Of DNA Recombination Positive Regulation Of Receptor-mediated Endocytosis
Pathways		PRC2 methylates histones and DNA PKMTs methylate histone lysines	Apoptosis induced DNA fragmentation Formation of Senescence-Associated Heterochromatin Foci (SAHF)
Drugs
Diseases
GWAS		Body size at age 10 ( 32376654) Chronic mountain sickness ( 31417607) Diastolic blood pressure ( 30224653) Diverticular disease ( 30177863) Height ( 28552196) Lung function (FEV1/FVC) ( 30804560) Manganese levels ( 26025379) Obesity-related traits ( 23251661) Opioid use cessation ( 31936517) Pulmonary function ( 21946350) Response to fenofibrate (LDL cholesterol levels) ( 27002377) Schizophrenia, bipolar disorder or major depressive disorder ( 34099189)
Interacting Genes		18 interacting genes: APP EED H1-1 H1-2 HMBOX1 JMJD6 KRTAP10-8 LDOC1 MDFI PICK1 RALYL RBBP4 SUZ12 THAP1 TRIM55 TRIM63 TSPYL2 ZNF408	54 interacting genes: AEBP2 APP CCNA1 CCNA2 CCNB1 CCND2 CCNE1 CDK1 CDK11B CDK2 CDK4 CDK5 CDK6 CDK7 CDKN1B CRP CTCFL EED EHMT2 EP300 EZH2 GADD45A GZMA IRAK4 KAT2B LIMK1 LIMK2 LOX NAP1L1 NAP1L4 NASP NSD3 PAK4 PARP1 PARP3 PELP1 PRDM1 PRKCA PRKCB PRKCD PRKCE PRKCZ PRKDC PTMA RBBP4 RPS6KA5 SET SMYD5 SNCA SUZ12 TAF1 TERF1 TERF2IP TLK1
Entrez ID		121536	3024
HPRD ID		16477	00820
Ensembl ID		ENSG00000139154	ENSG00000124610
Uniprot IDs		Q6ZN18	Q02539
PDB IDs		5WAI 5Y0U 5Y1U 6C23 6C24 6WKR 7KSO 8EQV 8FYH 8T9G 8TAS 8TB9 8VMI 8VML 8VNV 8VNZ 9C8U 9DCH	9J8O
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Nucleobase-containing Compound Metabolic Process Chromatin Remodeling Identical Protein Binding Facultative Heterochromatin Formation ESC/E(Z) Complex Chromatin Organization Protein-DNA Complex Assembly Negative Regulation Of Transcription By RNA Polymerase II Nucleosome Assembly Regulation Of Nucleobase-containing Compound Metabolic Process Nucleus Nucleosomal DNA Binding Nucleosome Organization Negative Regulation Of Metabolic Process Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of DNA-templated Transcription Positive Regulation Of Receptor-mediated Endocytosis Sex Chromatin Negative Regulation Of RNA Metabolic Process Regulation Of Transcription By RNA Polymerase II Chromatin Silencing Complex Negative Regulation Of Macromolecule Metabolic Process Chromatin DNA Binding Regulation Of Primary Metabolic Process Epigenetic Regulation Of Gene Expression Protein-containing Complex Assembly Regulation Of Receptor-mediated Endocytosis Protein-containing Complex Organization Negative Regulation Of DNA Metabolic Process Positive Regulation Of Receptor Internalization Heterochromatin Formation Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Chromosome Chromatin Positive Regulation Of Endocytosis Chromosome Condensation Negative Regulation Of Gene Expression, Epigenetic Amyloid-beta Complex Growth Cone Lamellipodium Neuron Projection Organization Regulation Of RNA Metabolic Process Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Negative Regulation Of Macromolecule Biosynthetic Process Oligodendrocyte Differentiation Histone H4R3 Demethylase Activity Peptidyl-lysine Hydroxylation To 5-hydroxy-L-lysine Peptidyl-lysine 5-dioxygenase Activity	Chromatin Organization Protein Serine Kinase Activity Protein Serine/threonine Kinase Activity Chromatin Remodeling Nucleus Protein Kinase Activity Kinase Activity Cyclin-dependent Protein Kinase Holoenzyme Complex Regulation Of Nucleobase-containing Compound Metabolic Process Transferase Activity G1/S Transition Of Mitotic Cell Cycle Cell Cycle G1/S Phase Transition Regulation Of RNA Metabolic Process Nucleoplasm Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Protein Phosphorylation Regulation Of Gene Expression Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Phosphorylation Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Mitotic Cell Cycle Phase Transition Regulation Of Metabolic Process Cyclin-dependent Protein Serine/threonine Kinase Activity Regulation Of Cell Cycle Cell Cycle Phase Transition Regulation Of Cell Cycle Process Negative Regulation Of Metabolic Process Macromolecule Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Metabolic Process Cellular Response To Stress Cellular Response To Oxygen-containing Compound Negative Regulation Of Biosynthetic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Histone Binding Positive Regulation Of Macromolecule Metabolic Process Protein Modification Process Response To Stress Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity Negative Regulation Of RNA Metabolic Process ESC/E(Z) Complex Regulation Of Cell Cycle Phase Transition Cell Division Diacylglycerol-dependent Serine/threonine Kinase Activity Protein Localization To Chromosome
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