AEBP2 and RBBP4

Number of citations of the paper that reports this interaction (PMID 15225548)
146

Data Source:
HPRD (in vitro)

		AEBP2	RBBP4
Gene Name		AE binding protein 2	retinoblastoma binding protein 4
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm ESC/E(Z) Complex	Nuclear Chromatin Nucleus Nucleoplasm Sin3 Complex NuRD Complex NURF Complex CAF-1 Complex ESC/E(Z) Complex Protein Complex
	Molecular Function	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Negative Regulation Of Transcription Transcription Corepressor Activity Metal Ion Binding	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding Protein Binding DNA-dependent ATPase Activity Nucleosomal DNA Binding Histone Binding Histone Deacetylase Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated Gene Expression Chromatin Modification Regulation Of Gene Expression, Epigenetic Negative Regulation Of Gene Expression, Epigenetic	G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle DNA Replication Chromatin Organization Nucleosome Assembly DNA Replication-dependent Nucleosome Assembly DNA Replication-independent Nucleosome Assembly Chromatin Remodeling Transcription, DNA-templated Regulation Of Transcription, DNA-templated Negative Regulation Of Cell Proliferation Gene Expression Chromatin Assembly CENP-A Containing Nucleosome Assembly Regulation Of Gene Expression, Epigenetic ATP-dependent Chromatin Remodeling Negative Regulation Of Gene Expression, Epigenetic Regulation Of Cell Cycle
Pathways		Epigenetic regulation of gene expression PRC2 methylates histones and DNA	Chromosome Maintenance Chromatin organization HDACs deacetylate histones RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription RNA Polymerase I Transcription Initiation RNA Polymerase I Transcription RNA Polymerase I Promoter Clearance Deposition of new CENPA-containing nucleosomes at the centromere Cellular Senescence Epigenetic regulation of gene expression G2/M Transition G0 and Early G1 PRC2 methylates histones and DNA Cell Cycle, Mitotic Chromatin modifying enzymes Nucleosome assembly Oxidative Stress Induced Senescence Mitotic G2-G2/M phases Mitotic G1-G1/S phases Polo-like kinase mediated events
Drugs
Diseases
GWAS		Obesity-related traits ( 23251661) Pulmonary function ( 21946350)
Protein-Protein Interactions		10 interactors: APP EED HIST1H1A HIST1H1C HMBOX1 JMJD6 LDOC1 RALYL RBBP4 SUZ12	50 interactors: AEBP2 ANXA7 BCL11B BRCA1 BRMS1 BRMS1L CDKN1A CHAF1B CREB1 CREBBP DHX30 EED ESR1 EZH2 GATAD2B HAT1 HDAC1 HDAC2 HDAC3 HDAC4 HIST1H1A HIST2H2AC HIST2H3C HIST2H4A HIST3H3 HMOX2 ING1 LINC00152 LMNA MBD2 MBD3 MBD3L2 MTA1 MTA2 NR2E3 RB1 RBBP7 RBP1 RPN1 RPN2 SAP30 SIN3A SMN1 SP1 SP3 SPEN SUV39H1 TK1 TSSK3 XRCC6
Entrez ID		121536	5928
HPRD ID		16477	04232
Ensembl ID			ENSG00000162521
Uniprot IDs		Q6ZN18	Q09028
PDB IDs			2XU7 3GFC
Enriched GO Terms of Interacting Partners?		Chromatin Organization Chromosome Organization Negative Regulation Of Gene Expression, Epigenetic Nucleosome Assembly Chromatin Assembly Nucleosome Organization Chromatin Assembly Or Disassembly Protein-DNA Complex Assembly DNA Packaging Chromatin Modification Regulation Of Gene Expression, Epigenetic DNA Conformation Change Organelle Organization Histone Modification RNA Metabolic Process Histone H3-R2 Demethylation Histone H4-R3 Demethylation Peptidyl-lysine Hydroxylation To 5-hydroxy-L-lysine Gene Expression Synaptic Growth At Neuromuscular Junction Transcription, DNA-templated RNA Biosynthetic Process Histone Methylation Negative Regulation Of Gene Expression Cell Recognition Collateral Sprouting In Absence Of Injury Cellular Macromolecular Complex Assembly Regulation Of Transcription, DNA-templated Collateral Sprouting Axon Midline Choice Point Recognition Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Protein Methylation Regulation Of RNA Metabolic Process Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Nucleobase-containing Compound Metabolic Process Nucleosome Positioning Axon Choice Point Recognition Recognition Of Apoptotic Cell Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Neuron Remodeling DNA Replication-dependent Nucleosome Assembly Regulation Of Gene Expression Cellular Component Assembly Regulation Of Nitrogen Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Histone H3-K27 Methylation Regulation Of Histone H3-K27 Methylation Negative Regulation Of Cellular Metabolic Process	Chromatin Organization Chromosome Organization Negative Regulation Of Gene Expression Regulation Of Gene Expression, Epigenetic Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Gene Expression, Epigenetic Chromatin Modification Negative Regulation Of Biosynthetic Process Negative Regulation Of Cellular Metabolic Process Gene Expression Regulation Of Transcription From RNA Polymerase II Promoter Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Gene Expression Transcription, DNA-templated Nucleobase-containing Compound Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Transcription, DNA-templated Cellular Nitrogen Compound Metabolic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process RNA Biosynthetic Process Organelle Organization Histone Modification Regulation Of RNA Metabolic Process Cellular Macromolecule Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Macromolecule Biosynthetic Process Nitrogen Compound Metabolic Process RNA Metabolic Process Cellular Metabolic Process Chromatin Remodeling Histone Deacetylation Positive Regulation Of Transcription, DNA-templated Protein Deacetylation Biosynthetic Process ATP-dependent Chromatin Remodeling Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Biosynthetic Process Regulation Of Metabolic Process Rhythmic Process Chromatin Silencing Histone H3-K9 Modification Positive Regulation Of Metabolic Process Metabolic Process
Tagcloud ?		chromatin complexes components constitute creates domains establishing feedback form h2a h2aub h3k27 h3k27me3 histone jarid2 k27 key loop monoubiquitination nucleosomes pcr2 polycomb prc1 prc2 promotes provides repression step trimethylation	bfls borjeson charged coregulator deacetylase disordered fog1 forssman gal4 homeodomain impair implicates insert lehmann lymphoblastic mta1 nucleosome nurd nurf55 overlaps pair phf6 pocket propeller recognizing remodeling repression su top
Tagcloud (Difference) ?		chromatin complexes components constitute creates domains establishing feedback form h2a h2aub h3k27 h3k27me3 histone jarid2 k27 key loop monoubiquitination nucleosomes pcr2 polycomb prc1 prc2 promotes provides step trimethylation	bfls borjeson charged coregulator deacetylase disordered fog1 forssman gal4 homeodomain impair implicates insert lehmann lymphoblastic mta1 nucleosome nurd nurf55 overlaps pair phf6 pocket propeller recognizing remodeling su top
Tagcloud (Intersection) ?		repression