AEBP2 and SUZ12

Number of citations of the paper that reports this interaction (PubMedID 15225548)
0

Data Source:
HPRD (in vitro)

		AEBP2	SUZ12
Description		AE binding protein 2	SUZ12 polycomb repressive complex 2 subunit
Image
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm ESC/E(Z) Complex	Sex Chromatin Nucleus Nucleoplasm Chromatin Silencing Complex Nucleolus RSC-type Complex Nuclear Body Protein-DNA Complex ESC/E(Z) Complex Ribonucleoprotein Complex
	Molecular Function	DNA Binding Transcription Coregulator Activity Protein Binding Zinc Ion Binding Metal Ion Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Transcription Corepressor Binding Chromatin Binding RNA Binding Protein Binding Enzyme Activator Activity Zinc Ion Binding Chromatin DNA Binding Sequence-specific DNA Binding Metal Ion Binding Histone H3K9me2/3 Reader Activity LncRNA Binding Promoter-specific Chromatin Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Organization Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Organization Cell Population Proliferation Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell Differentiation Oligodendrocyte Differentiation Random Inactivation Of X Chromosome Facultative Heterochromatin Formation
Pathways		PRC2 methylates histones and DNA PKMTs methylate histone lysines	PRC2 methylates histones and DNA Oxidative Stress Induced Senescence PKMTs methylate histone lysines SUMOylation of chromatin organization proteins Activation of anterior HOX genes in hindbrain development during early embryogenesis Regulation of PTEN gene transcription Regulation of PTEN gene transcription Transcriptional Regulation by E2F6 HCMV Early Events Defective pyroptosis Negative Regulation of CDH1 Gene Transcription Regulation of PD-L1(CD274) transcription
Drugs
Diseases
GWAS		Body size at age 10 ( 32376654) Chronic mountain sickness ( 31417607) Diastolic blood pressure ( 30224653) Diverticular disease ( 30177863) Height ( 28552196) Lung function (FEV1/FVC) ( 30804560) Manganese levels ( 26025379) Obesity-related traits ( 23251661) Opioid use cessation ( 31936517) Pulmonary function ( 21946350) Response to fenofibrate (LDL cholesterol levels) ( 27002377) Schizophrenia, bipolar disorder or major depressive disorder ( 34099189)	High chromosomal aberration frequency (chromosome type) ( 31586183) Hip circumference adjusted for BMI ( 25673412)
Interacting Genes		18 interacting genes: APP EED H1-1 H1-2 HMBOX1 JMJD6 KRTAP10-8 LDOC1 MDFI PICK1 RALYL RBBP4 SUZ12 THAP1 TRIM55 TRIM63 TSPYL2 ZNF408	18 interacting genes: AEBP2 BCL11A CDK19 CDK8 CREB1 EZH2 H1-1 H3-4 LATS2 MED17 MED6 PAXIP1 PJA1 PRDM14 RNF10 UBC UBE2I WDR77
Entrez ID		121536	23512
HPRD ID		16477	06949
Ensembl ID		ENSG00000139154	ENSG00000178691
Uniprot IDs		Q6ZN18	J3QQW9 Q15022
PDB IDs		5WAI 5Y0U 5Y1U 6C23 6C24 6WKR 7KSO 8EQV 8FYH 8T9G 8TAS 8TB9 8VMI 8VML 8VNV 8VNZ 9C8U 9DCH	4W2R 5HYN 5IJ7 5IJ8 5LS6 5WAI 5WAK 5WG6 6B3W 6C23 6C24 6NQ3 6WKR 7AT8 7KSO 7KSR 7KTP 7TD5 8EQV 8FYH 8T9G 8TAS 8TB9 8VMI 8VML 8VNV 8VNZ 9C8U 9DCH
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Nucleobase-containing Compound Metabolic Process Chromatin Remodeling Identical Protein Binding Facultative Heterochromatin Formation ESC/E(Z) Complex Chromatin Organization Protein-DNA Complex Assembly Negative Regulation Of Transcription By RNA Polymerase II Nucleosome Assembly Regulation Of Nucleobase-containing Compound Metabolic Process Nucleus Nucleosomal DNA Binding Nucleosome Organization Negative Regulation Of Metabolic Process Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of DNA-templated Transcription Positive Regulation Of Receptor-mediated Endocytosis Sex Chromatin Negative Regulation Of RNA Metabolic Process Regulation Of Transcription By RNA Polymerase II Chromatin Silencing Complex Negative Regulation Of Macromolecule Metabolic Process Chromatin DNA Binding Regulation Of Primary Metabolic Process Epigenetic Regulation Of Gene Expression Protein-containing Complex Assembly Regulation Of Receptor-mediated Endocytosis Protein-containing Complex Organization Negative Regulation Of DNA Metabolic Process Positive Regulation Of Receptor Internalization Heterochromatin Formation Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Chromosome Chromatin Positive Regulation Of Endocytosis Chromosome Condensation Negative Regulation Of Gene Expression, Epigenetic Amyloid-beta Complex Growth Cone Lamellipodium Neuron Projection Organization Regulation Of RNA Metabolic Process Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Negative Regulation Of Macromolecule Biosynthetic Process Oligodendrocyte Differentiation Histone H4R3 Demethylase Activity Peptidyl-lysine Hydroxylation To 5-hydroxy-L-lysine Peptidyl-lysine 5-dioxygenase Activity	Nucleoplasm Protein Modification Process ESC/E(Z) Complex Regulation Of Transcription By RNA Polymerase II Positive Regulation Of DNA-templated Transcription Initiation Positive Regulation Of Transcription Initiation By RNA Polymerase II Regulation Of Transcription Initiation By RNA Polymerase II Protein Modification By Small Protein Conjugation Inner Cell Mass Cell Fate Commitment Regulation Of DNA-templated Transcription Initiation Protein-DNA Complex Assembly Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Nucleus Regulation Of Nucleobase-containing Compound Metabolic Process CKM Complex Mediator Complex Regulation Of Developmental Process Post-translational Protein Modification Maintenance Of Cell Number Regulation Of RNA Metabolic Process Transcription Coregulator Activity DNA Replication-dependent Chromatin Assembly Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Protein Metabolic Process Transferase Complex Regulation Of Multicellular Organismal Process Regulation Of Primary Metabolic Process Negative Regulation Of RNA Metabolic Process G1 To G0 Transition Chromatin Organization Positive Regulation Of RNA Metabolic Process Protein Ubiquitination Chromatin DNA Binding Response To L-glutamate Regulation Of Cell Differentiation Regulation Of Transcription Elongation By RNA Polymerase II Chromatin Remodeling Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Gliogenesis Positive Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Chromosome Regulation Of DNA-templated Transcription Elongation Rhythmic Process Nucleosome Assembly
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?