AEBP2 and SUZ12

Number of citations of the paper that reports this interaction (PMID 15225548)
146

Data Source:
HPRD (in vitro)

		AEBP2	SUZ12
Gene Name		AE binding protein 2	SUZ12 polycomb repressive complex 2 subunit
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm ESC/E(Z) Complex	Sex Chromatin Nucleus Nucleoplasm Nucleolus ESC/E(Z) Complex
	Molecular Function	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Negative Regulation Of Transcription Transcription Corepressor Activity Metal Ion Binding	Chromatin Binding RNA Binding Protein Binding Methylated Histone Binding Histone Methyltransferase Activity Sequence-specific DNA Binding Metal Ion Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated Gene Expression Chromatin Modification Regulation Of Gene Expression, Epigenetic Negative Regulation Of Gene Expression, Epigenetic	Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated Positive Regulation Of Cell Proliferation Gene Expression Histone Methylation Histone Ubiquitination Regulation Of Gene Expression, Epigenetic Negative Regulation Of Cell Differentiation Negative Regulation Of Gene Expression, Epigenetic
Pathways		Epigenetic regulation of gene expression PRC2 methylates histones and DNA	Oxidative Stress Induced Senescence Cellular Senescence Epigenetic regulation of gene expression PRC2 methylates histones and DNA
Drugs
Diseases
GWAS		Obesity-related traits ( 23251661) Pulmonary function ( 21946350)
Protein-Protein Interactions		10 interactors: APP EED HIST1H1A HIST1H1C HMBOX1 JMJD6 LDOC1 RALYL RBBP4 SUZ12	15 interactors: AEBP2 CDK19 CDK8 CREB1 CTCF EZH2 HIST1H1A HIST3H3 MED17 MED6 PAXIP1 PJA1 UBE2I USP7 WDR77
Entrez ID		121536	23512
HPRD ID		16477	06949
Ensembl ID			ENSG00000178691
Uniprot IDs		Q6ZN18	A8K1U9 J3QQW9 Q15022
PDB IDs
Enriched GO Terms of Interacting Partners?		Chromatin Organization Chromosome Organization Negative Regulation Of Gene Expression, Epigenetic Nucleosome Assembly Chromatin Assembly Nucleosome Organization Chromatin Assembly Or Disassembly Protein-DNA Complex Assembly DNA Packaging Chromatin Modification Regulation Of Gene Expression, Epigenetic DNA Conformation Change Organelle Organization Histone Modification RNA Metabolic Process Histone H3-R2 Demethylation Histone H4-R3 Demethylation Peptidyl-lysine Hydroxylation To 5-hydroxy-L-lysine Gene Expression Synaptic Growth At Neuromuscular Junction Transcription, DNA-templated RNA Biosynthetic Process Histone Methylation Negative Regulation Of Gene Expression Cell Recognition Collateral Sprouting In Absence Of Injury Cellular Macromolecular Complex Assembly Regulation Of Transcription, DNA-templated Collateral Sprouting Axon Midline Choice Point Recognition Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Protein Methylation Regulation Of RNA Metabolic Process Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Nucleobase-containing Compound Metabolic Process Nucleosome Positioning Axon Choice Point Recognition Recognition Of Apoptotic Cell Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Neuron Remodeling DNA Replication-dependent Nucleosome Assembly Regulation Of Gene Expression Cellular Component Assembly Regulation Of Nitrogen Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Histone H3-K27 Methylation Regulation Of Histone H3-K27 Methylation Negative Regulation Of Cellular Metabolic Process	Regulation Of Transcription From RNA Polymerase II Promoter Chromosome Organization Chromatin Organization Organelle Organization Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Transcription From RNA Polymerase II Promoter Maintenance Of DNA Methylation Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Chromatin Modification Transcription, DNA-templated RNA Metabolic Process RNA Biosynthetic Process Nitrogen Compound Metabolic Process Gene Expression Cellular Metabolic Process Positive Regulation Of Transcription, DNA-templated Transcription Initiation From RNA Polymerase II Promoter Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Cellular Protein Modification Process Regulation Of Gene Expression, Epigenetic Positive Regulation Of Transcription From RNA Polymerase II Promoter DNA Metabolic Process DNA-templated Transcription, Initiation Negative Regulation Of Transcription, DNA-templated Regulation Of Histone Acetylation Positive Regulation Of Metabolic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Peptidyl-lysine Modification Regulation Of Histone Methylation Cellular Macromolecule Biosynthetic Process DNA Methylation Positive Regulation Of Histone H3-K36 Methylation Positive Regulation Of SUMO Transferase Activity Macromolecule Biosynthetic Process Negative Regulation Of Gene Expression Regulation Of Metabolic Process Negative Regulation Of Gene Expression, Epigenetic Negative Regulation Of Biosynthetic Process
Tagcloud ?		chromatin complexes components constitute creates domains establishing feedback form h2a h2aub h3k27 h3k27me3 histone jarid2 k27 key loop monoubiquitination nucleosomes pcr2 polycomb prc1 prc2 promotes provides repression step trimethylation	arise border cartilage cooperates craniofacial crest differentiate ectoderm eed embryogenesis expand extensively ezh2 fails h3k27 learnt migrate neural occupancy plate polycomb prc2 repressive slug snail2 specification trimethylation vertebrate xenopus
Tagcloud (Difference) ?		chromatin complexes components constitute creates domains establishing feedback form h2a h2aub h3k27me3 histone jarid2 k27 key loop monoubiquitination nucleosomes pcr2 prc1 promotes provides repression step	arise border cartilage cooperates craniofacial crest differentiate ectoderm eed embryogenesis expand extensively ezh2 fails learnt migrate neural occupancy plate repressive slug snail2 specification vertebrate xenopus
Tagcloud (Intersection) ?		h3k27 polycomb prc2 trimethylation