AEBP2 and EED

Number of citations of the paper that reports this interaction (PMID 15225548)
146

Data Source:
HPRD (in vitro)

		AEBP2	EED
Gene Name		AE binding protein 2	embryonic ectoderm development
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm ESC/E(Z) Complex	Sex Chromatin Nucleus Nucleoplasm Nucleolus Cytoplasm ESC/E(Z) Complex Pronucleus
	Molecular Function	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Negative Regulation Of Transcription Transcription Corepressor Activity Metal Ion Binding	Chromatin Binding Protein Binding Histone Methyltransferase Activity Identical Protein Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated Gene Expression Chromatin Modification Regulation Of Gene Expression, Epigenetic Negative Regulation Of Gene Expression, Epigenetic	Regulation Of Gene Expression By Genetic Imprinting Transcription, DNA-templated Gene Expression Histone Methylation Regulation Of Gene Expression, Epigenetic Negative Regulation Of Gene Expression, Epigenetic Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Histone H3-K27 Methylation
Pathways		Epigenetic regulation of gene expression PRC2 methylates histones and DNA	Oxidative Stress Induced Senescence Cellular Senescence Epigenetic regulation of gene expression PRC2 methylates histones and DNA
Drugs
Diseases
GWAS		Obesity-related traits ( 23251661) Pulmonary function ( 21946350)
Protein-Protein Interactions		10 interactors: APP EED HIST1H1A HIST1H1C HMBOX1 JMJD6 LDOC1 RALYL RBBP4 SUZ12	38 interactors: AEBP2 ANXA5 BRCA1 CDK2AP2 CTSL DNMT1 DNMT3A DNMT3B DUSP23 EHMT1 EPC2 EZH1 EZH2 FHL1 HDAC1 HDAC2 HDAC3 HIST1H1A HIST1H3A ITGA4 ITGAE ITGB7 MAP1LC3B NUDT21 PINK1 PJA1 PPP1CA PPP1R8 RBBP4 RPS10 SELENBP1 SMYD3 TGS1 TSC22D1 UBE2W YY1 ZBED8 ZFP42
Entrez ID		121536	8726
HPRD ID		16477	09343
Ensembl ID			ENSG00000074266
Uniprot IDs		Q6ZN18	E9PJK2 O75530
PDB IDs			3IIW 3IIY 3IJ0 3IJ1 3IJC 3JPX 3JZG 3JZH 3JZN 3K26 3K27
Enriched GO Terms of Interacting Partners?		Chromatin Organization Chromosome Organization Negative Regulation Of Gene Expression, Epigenetic Nucleosome Assembly Chromatin Assembly Nucleosome Organization Chromatin Assembly Or Disassembly Protein-DNA Complex Assembly DNA Packaging Chromatin Modification Regulation Of Gene Expression, Epigenetic DNA Conformation Change Organelle Organization Histone Modification RNA Metabolic Process Histone H3-R2 Demethylation Histone H4-R3 Demethylation Peptidyl-lysine Hydroxylation To 5-hydroxy-L-lysine Gene Expression Synaptic Growth At Neuromuscular Junction Transcription, DNA-templated RNA Biosynthetic Process Histone Methylation Negative Regulation Of Gene Expression Cell Recognition Collateral Sprouting In Absence Of Injury Cellular Macromolecular Complex Assembly Regulation Of Transcription, DNA-templated Collateral Sprouting Axon Midline Choice Point Recognition Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Protein Methylation Regulation Of RNA Metabolic Process Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Nucleobase-containing Compound Metabolic Process Nucleosome Positioning Axon Choice Point Recognition Recognition Of Apoptotic Cell Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Neuron Remodeling DNA Replication-dependent Nucleosome Assembly Regulation Of Gene Expression Cellular Component Assembly Regulation Of Nitrogen Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Histone H3-K27 Methylation Regulation Of Histone H3-K27 Methylation Negative Regulation Of Cellular Metabolic Process	Negative Regulation Of Gene Expression, Epigenetic Regulation Of Gene Expression, Epigenetic Chromatin Organization Chromosome Organization Chromatin Modification Negative Regulation Of Gene Expression DNA Methylation DNA Methylation On Cytosine Organelle Organization Negative Regulation Of Transcription, DNA-templated DNA Modification Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Methylation Negative Regulation Of Transcription From RNA Polymerase II Promoter C-5 Methylation Of Cytosine Nucleobase-containing Compound Metabolic Process Negative Regulation Of Biosynthetic Process Regulation Of Transcription, DNA-templated Gene Expression Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process RNA Biosynthetic Process Negative Regulation Of Cellular Metabolic Process Regulation Of Gene Expression Regulation Of RNA Metabolic Process Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Histone H3-K9 Methylation Histone H3-K27 Methylation DNA Metabolic Process Chromatin Silencing Histone H3-K9 Modification Transcription, DNA-templated Gene Silencing Positive Regulation Of Histone H3-K4 Methylation Regulation Of Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Histone Modification Negative Regulation Of Histone Methylation Cell-matrix Adhesion Involved In Ameboidal Cell Migration Histone H4 Deacetylation Cellular Metabolic Process Regulation Of Histone H3-K4 Methylation Cellular Macromolecule Biosynthetic Process Circadian Regulation Of Gene Expression RNA Metabolic Process Macromolecule Biosynthetic Process
Tagcloud ?		chromatin complexes components constitute creates domains establishing feedback form h2a h2aub h3k27 h3k27me3 histone jarid2 k27 key loop monoubiquitination nucleosomes pcr2 polycomb prc1 prc2 promotes provides repression step trimethylation	70z bait cdnas coexpressed coimmunoprecipitated compositions confirming developmentally drosophila ectoderm esc ezh2 fragment gal4 homolog hybrid hypomorphic lethal mammalian polycomb repeats represses repressor silenced t1031a t1040c wd40 yeast zeste
Tagcloud (Difference) ?		chromatin complexes components constitute creates domains establishing feedback form h2a h2aub h3k27 h3k27me3 histone jarid2 k27 key loop monoubiquitination nucleosomes pcr2 prc1 prc2 promotes provides repression step trimethylation	70z bait cdnas coexpressed coimmunoprecipitated compositions confirming developmentally drosophila ectoderm esc ezh2 fragment gal4 homolog hybrid hypomorphic lethal mammalian repeats represses repressor silenced t1031a t1040c wd40 yeast zeste
Tagcloud (Intersection) ?		polycomb