PRAP1 and SGTB

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		PRAP1	SGTB
Description		proline rich acidic protein 1	small glutamine rich tetratricopeptide repeat co-chaperone beta
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Endoplasmic Reticulum	Membrane TRC Complex
	Molecular Function	Protein Binding Lipid Binding Triglyceride Binding	Protein Binding Hsp70 Protein Binding Identical Protein Binding Protein-folding Chaperone Binding Molecular Adaptor Activity
	Biological Process	DNA Damage Response DNA Damage Response, Signal Transduction By P53 Class Mediator Negative Regulation Of Apoptotic Process Cellular Response To X-ray Deactivation Of Mitotic Spindle Assembly Checkpoint Positive Regulation Of Intestinal Lipid Absorption Positive Regulation Of Triglyceride Transport Positive Regulation Of Phospholipid Transport	Post-translational Protein Targeting To Endoplasmic Reticulum Membrane Protein Homooligomerization Protein Heterooligomerization
Pathways
Drugs
Diseases
GWAS		Nonunion in individuals with fractures ( 30680360)	Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Intralaminar thalamic nuclei volume ( 34006833) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		11 interacting genes: AHNAK2 ASPH CEP19 GRB2 HSPA6 MEOX2 MRFAP1 SGTA SGTB UBQLN1 UBQLN2	116 interacting genes: ABCG4 ADAT2 ADIPOQ AGR2 AGR3 ASPH BTC C1QA C1QL4 C1QTNF5 C1QTNF6 C5orf46 CALR CCL3L3 CD200R1 CD3D CD68 CD79B CD99L2 CDH15 CDSN CMPK1 COL10A1 COL1A2 COLQ COMP CREB3L3 CSH1 CSH2 CTAG1A CTAG1B CYB5R1 DEFA6 DEXI DMKN ECM1 EFEMP2 EMCN ERP29 ETNK1 EVA1A FBN1 FGF21 FZD7 GALNT11 GGH GIP GPX7 GYPA HSP90B1 HSPA13 IL6R IL6ST ITPRIP ITPRIPL1 KCNE5 KRT1 LAMP3 LAT LCN2 LHB LMO2 MYDGF NAXD NME3 OSMR PAGE3 PDIA6 PGRMC1 PODXL PPIB PPIC PRAP1 PRB1 PRB3 PRB4 PRR4 PSORS1C2 RAI2 RCN1 RNASE10 RNF144A RNF144B RNF170 SDC4 SDF2L1 SELENOM SERPINE1 SERPINF1 SERPINI2 SGCA SGTA SHISA5 SIL1 SLPI SOD3 SPINK4 SPP1 SRGN SYT11 SYT4 TFF1 TMEM108 TMEM123 TMPO TMUB1 TNFRSF19 TNFSF13 TXNDC12 UBL4A UPK3A VEGFC VWC2 WFDC12 ZG16 ZG16B
Entrez ID		118471	54557
HPRD ID		17898	18049
Ensembl ID		ENSG00000165828	ENSG00000197860
Uniprot IDs		A6XND8 Q96NZ9	Q96EQ0
PDB IDs
Enriched GO Terms of Interacting Partners?		TRC Complex Positive Regulation Of ERAD Pathway Regulation Of ERAD Pathway Positive Regulation Of Response To Endoplasmic Reticulum Stress Positive Regulation Of Proteolysis Regulation Of Response To Endoplasmic Reticulum Stress Post-translational Protein Targeting To Endoplasmic Reticulum Membrane ERAD Pathway Positive Regulation Of Proteasomal Protein Catabolic Process Regulation Of Proteolysis Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Protein Targeting To ER COP9 Signalosome Establishment Of Protein Localization To Endoplasmic Reticulum Regulation Of Proteasomal Protein Catabolic Process Polyubiquitin Modification-dependent Protein Binding Positive Regulation Of Protein Catabolic Process Response To Endoplasmic Reticulum Stress Guanyl-nucleotide Exchange Factor Adaptor Activity Negative Regulation Of Store-operated Calcium Channel Activity Vesicle Targeting, Trans-Golgi To Periciliary Membrane Compartment Cytoplasm Protein Targeting To Membrane Positive Regulation Of Protein Metabolic Process Peptidyl-aspartic Acid 3-dioxygenase Activity Regulation Of Transmembrane Transporter Activity Roof Of Mouth Development Regulation Of Monoatomic Ion Transmembrane Transporter Activity Grb2-EGFR Complex Autophagosome Negative Regulation Of G Protein-coupled Receptor Internalization Regulation Of Protein Catabolic Process Autophagosome Assembly Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Cellular Response To Stress Autophagosome Organization Negative Regulation Of Toll-like Receptor 3 Signaling Pathway BAT3 Complex Binding Negative Regulation Of Clathrin-dependent Endocytosis Vesicle Targeting, To, From Or Within Golgi Activation Of Store-operated Calcium Channel Activity Identical Protein Binding Somite Specification Proteasomal Protein Catabolic Process Positive Regulation Of Store-operated Calcium Channel Activity Regulation Of Calcium Ion Transmembrane Transport Neurotrophin TRKA Receptor Binding Cellular Heat Acclimation Regulation Of Cellular Response To Stress Negative Regulation Of ERAD Pathway	Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Protein Binding Collagen Trimer Endoplasmic Reticulum Chaperone Complex Endoplasmic Reticulum Extracellular Matrix Protein Folding Smooth Endoplasmic Reticulum Extracellular Matrix Structural Constituent Serine-type Endopeptidase Inhibitor Activity Sarcoplasmic Reticulum Lumen Extracellular Exosome Interleukin-6 Binding Interleukin-6 Receptor Activity Oncostatin-M Receptor Complex Melanosome Response To Bacterium Hormone Activity Interleukin-6 Receptor Complex Ciliary Neurotrophic Factor Receptor Complex Oncostatin-M Receptor Activity Positive Regulation Of Transport Memory Response To Endoplasmic Reticulum Stress Defense Response To Bacterium Ciliary Neurotrophic Factor Receptor Activity Interleukin-11 Receptor Activity Interleukin-11 Binding Oncostatin-M-mediated Signaling Pathway Regulation Of Smooth Muscle Cell-matrix Adhesion Regulation Of Immune System Process Sequestering Of Calcium Ion Biomineral Tissue Development Basement Membrane Ciliary Neurotrophic Factor-mediated Signaling Pathway ERAD Pathway Growth Factor Activity Golgi Lumen Positive Regulation Of Acute Inflammatory Response Ciliary Neurotrophic Factor Receptor Binding Response To Stress Regulation Of Cell-substrate Adhesion
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