PRAP1 and HSPA6

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		PRAP1	HSPA6
Description		proline rich acidic protein 1	heat shock protein family A (Hsp70) member 6
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Endoplasmic Reticulum	Extracellular Region Nucleus Cytoplasm Centriole Cytosol Plasma Membrane COP9 Signalosome Secretory Granule Lumen Extracellular Exosome Blood Microparticle Ficolin-1-rich Granule Lumen
	Molecular Function	Protein Binding Lipid Binding Triglyceride Binding	Nucleotide Binding Protein Binding ATP Binding ATP Hydrolysis Activity Enzyme Binding Heat Shock Protein Binding Protein Folding Chaperone Unfolded Protein Binding ATP-dependent Protein Folding Chaperone
	Biological Process	DNA Damage Response DNA Damage Response, Signal Transduction By P53 Class Mediator Negative Regulation Of Apoptotic Process Cellular Response To X-ray Deactivation Of Mitotic Spindle Assembly Checkpoint Positive Regulation Of Intestinal Lipid Absorption Positive Regulation Of Triglyceride Transport Positive Regulation Of Phospholipid Transport	Protein Folding Response To Unfolded Protein Cellular Response To Heat Protein Refolding Cellular Heat Acclimation
Pathways			Regulation of HSF1-mediated heat shock response Neutrophil degranulation
Drugs
Diseases
GWAS		Nonunion in individuals with fractures ( 30680360)	Alanine aminotransferase levels ( 33547301) Birth weight ( 31043758) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Functional impairment in major depressive disorder, bipolar disorder and schizophrenia ( 24039173) Helicobacter pylori serologic status ( 23652523) Inflammatory bowel disease ( 23128233 28067908) Offspring birth weight ( 31043758) Ulcerative colitis ( 21297633 28067908)
Interacting Genes		11 interacting genes: AHNAK2 ASPH CEP19 GRB2 HSPA6 MEOX2 MRFAP1 SGTA SGTB UBQLN1 UBQLN2	18 interacting genes: ADCK5 AHCYL1 BAG4 C22orf15 CISH COMMD6 CYP4F12 DNAJB4 FLNA KRT222 LGALS7 LGALS7B PPIB PRAP1 RPA1 SNCA TERF1 WEE2-AS1
Entrez ID		118471	3310
HPRD ID		17898	00775
Ensembl ID		ENSG00000165828	ENSG00000173110
Uniprot IDs		A6XND8 Q96NZ9	A0A384NKX5 B3KSM6 P17066
PDB IDs			3FE1
Enriched GO Terms of Interacting Partners?		TRC Complex Positive Regulation Of ERAD Pathway Regulation Of ERAD Pathway Positive Regulation Of Response To Endoplasmic Reticulum Stress Positive Regulation Of Proteolysis Regulation Of Response To Endoplasmic Reticulum Stress Post-translational Protein Targeting To Endoplasmic Reticulum Membrane ERAD Pathway Positive Regulation Of Proteasomal Protein Catabolic Process Regulation Of Proteolysis Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Protein Targeting To ER COP9 Signalosome Establishment Of Protein Localization To Endoplasmic Reticulum Regulation Of Proteasomal Protein Catabolic Process Polyubiquitin Modification-dependent Protein Binding Positive Regulation Of Protein Catabolic Process Response To Endoplasmic Reticulum Stress Guanyl-nucleotide Exchange Factor Adaptor Activity Negative Regulation Of Store-operated Calcium Channel Activity Vesicle Targeting, Trans-Golgi To Periciliary Membrane Compartment Cytoplasm Protein Targeting To Membrane Positive Regulation Of Protein Metabolic Process Peptidyl-aspartic Acid 3-dioxygenase Activity Regulation Of Transmembrane Transporter Activity Roof Of Mouth Development Regulation Of Monoatomic Ion Transmembrane Transporter Activity Grb2-EGFR Complex Autophagosome Negative Regulation Of G Protein-coupled Receptor Internalization Regulation Of Protein Catabolic Process Autophagosome Assembly Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Cellular Response To Stress Autophagosome Organization Negative Regulation Of Toll-like Receptor 3 Signaling Pathway BAT3 Complex Binding Negative Regulation Of Clathrin-dependent Endocytosis Vesicle Targeting, To, From Or Within Golgi Activation Of Store-operated Calcium Channel Activity Identical Protein Binding Somite Specification Proteasomal Protein Catabolic Process Positive Regulation Of Store-operated Calcium Channel Activity Regulation Of Calcium Ion Transmembrane Transport Neurotrophin TRKA Receptor Binding Cellular Heat Acclimation Regulation Of Cellular Response To Stress Negative Regulation Of ERAD Pathway	Regulation Of B Cell Antigen Processing And Presentation Negative Regulation Of Exocytosis Immune Complex Clearance By Monocytes And Macrophages Negative Regulation Of Type I Hypersensitivity Negative Regulation Of Antibody-dependent Cellular Cytotoxicity Regulation Of Membrane Repolarization During Atrial Cardiac Muscle Cell Action Potential Regulation Of Protein Stability Positive Regulation Of Organelle Organization Protein Sequestering Activity Intracellular Membrane-bounded Organelle Telomere Maintenance Via Telomere Lengthening RNA-templated DNA Biosynthetic Process Telomere Maintenance Via Telomerase G-rich Strand Telomeric DNA Binding Response To Desipramine Negative Regulation Of Norepinephrine Uptake Phospholipase D Inhibitor Activity Positive Regulation Of SNARE Complex Assembly Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission Negative Regulation Of Establishment Of Protein Localization To Telomere Negative Regulation Of Establishment Of Protein-containing Complex Localization To Telomere Negative Regulation Of Establishment Of RNA Localization To Telomere Positive Regulation Of Shelterin Complex Assembly Negative Regulation Of MRNA Modification Positive Regulation Of Triglyceride Transport Positive Regulation Of Monoatomic Ion Transport Positive Regulation Of Cellular Component Organization
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