PRAP1 and MRFAP1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		PRAP1	MRFAP1
Description		proline rich acidic protein 1	Morf4 family associated protein 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Endoplasmic Reticulum	Nucleus Nucleoplasm Cytoplasm Perinuclear Region Of Cytoplasm
	Molecular Function	Protein Binding Lipid Binding Triglyceride Binding	Protein Binding
	Biological Process	DNA Damage Response DNA Damage Response, Signal Transduction By P53 Class Mediator Negative Regulation Of Apoptotic Process Cellular Response To X-ray Deactivation Of Mitotic Spindle Assembly Checkpoint Positive Regulation Of Intestinal Lipid Absorption Positive Regulation Of Triglyceride Transport Positive Regulation Of Phospholipid Transport
Pathways
Drugs
Diseases
GWAS		Nonunion in individuals with fractures ( 30680360)
Interacting Genes		11 interacting genes: AHNAK2 ASPH CEP19 GRB2 HSPA6 MEOX2 MRFAP1 SGTA SGTB UBQLN1 UBQLN2	40 interacting genes: ABI1 ABI2 ABI3 BRK1 C3orf62 C8orf33 CAVIN3 CCDC146 DCDC2 DNAJB5 DPY30 FCHSD2 GOLGA8F GOLGA8G HTT KIFC3 MAP1LC3B MORF4L1 MORF4L2 MTIF3 PAM16 PCBD2 PCNT PRAP1 PRKAA2 SDCBP SH2D4A SMU1 SUV39H2 TEX11 TK1 TPM2 TRIM47 TXN TXN2 UBTD1 UQCC2 WASHC1 ZDHHC17 ZNF655
Entrez ID		118471	93621
HPRD ID		17898	17589
Ensembl ID		ENSG00000165828	ENSG00000179010
Uniprot IDs		A6XND8 Q96NZ9	B3KQA0 Q9Y605
PDB IDs
Enriched GO Terms of Interacting Partners?		TRC Complex Positive Regulation Of ERAD Pathway Regulation Of ERAD Pathway Positive Regulation Of Response To Endoplasmic Reticulum Stress Positive Regulation Of Proteolysis Regulation Of Response To Endoplasmic Reticulum Stress Post-translational Protein Targeting To Endoplasmic Reticulum Membrane ERAD Pathway Positive Regulation Of Proteasomal Protein Catabolic Process Regulation Of Proteolysis Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Protein Targeting To ER COP9 Signalosome Establishment Of Protein Localization To Endoplasmic Reticulum Regulation Of Proteasomal Protein Catabolic Process Polyubiquitin Modification-dependent Protein Binding Positive Regulation Of Protein Catabolic Process Response To Endoplasmic Reticulum Stress Guanyl-nucleotide Exchange Factor Adaptor Activity Negative Regulation Of Store-operated Calcium Channel Activity Vesicle Targeting, Trans-Golgi To Periciliary Membrane Compartment Cytoplasm Protein Targeting To Membrane Positive Regulation Of Protein Metabolic Process Peptidyl-aspartic Acid 3-dioxygenase Activity Regulation Of Transmembrane Transporter Activity Roof Of Mouth Development Regulation Of Monoatomic Ion Transmembrane Transporter Activity Grb2-EGFR Complex Autophagosome Negative Regulation Of G Protein-coupled Receptor Internalization Regulation Of Protein Catabolic Process Autophagosome Assembly Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Cellular Response To Stress Autophagosome Organization Negative Regulation Of Toll-like Receptor 3 Signaling Pathway BAT3 Complex Binding Negative Regulation Of Clathrin-dependent Endocytosis Vesicle Targeting, To, From Or Within Golgi Activation Of Store-operated Calcium Channel Activity Identical Protein Binding Somite Specification Proteasomal Protein Catabolic Process Positive Regulation Of Store-operated Calcium Channel Activity Regulation Of Calcium Ion Transmembrane Transport Neurotrophin TRKA Receptor Binding Cellular Heat Acclimation Regulation Of Cellular Response To Stress Negative Regulation Of ERAD Pathway	SCAR Complex Positive Regulation Of Arp2/3 Complex-mediated Actin Nucleation Regulation Of Arp2/3 Complex-mediated Actin Nucleation Actin-based Cell Projection Regulation Of Actin Nucleation Positive Regulation Of Actin Nucleation Regulation Of Cell Projection Assembly Regulation Of Lamellipodium Assembly Positive Regulation Of Plasma Membrane Bounded Cell Projection Assembly Positive Regulation Of Organelle Organization Regulation Of Lamellipodium Organization Regulation Of Organelle Organization Regulation Of Organelle Assembly Cytoskeleton Actin Filament Organization Neuron Migration Cell Projection Morphogenesis Centriole Filopodium Tip Signaling Adaptor Activity Autophagosome Lamellipodium
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