HSPH1 and ADD1

Number of citations of the paper that reports this interaction (PMID 14733918)
1

Data Source:
HPRD (in vivo, in vitro)

		HSPH1	ADD1
Gene Name		heat shock 105kDa/110kDa protein 1	adducin 1 (alpha)
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Nucleoplasm Cytoplasm Cytosol Microtubule Extracellular Vesicular Exosome Endocytic Vesicle Lumen	Nucleus Nucleoplasm Cytosol Plasma Membrane Focal Adhesion F-actin Capping Protein Complex Postsynaptic Density Dendritic Spine Intermediate Filament Cytoskeleton Perinuclear Region Of Cytoplasm
	Molecular Function	Protein Binding ATP Binding Alpha-tubulin Binding	Actin Binding Structural Molecule Activity Calmodulin Binding Transcription Factor Binding Spectrin Binding T Cell Receptor Binding Protein Homodimerization Activity Poly(A) RNA Binding Protein Heterodimerization Activity Actin Filament Binding
	Biological Process	Receptor-mediated Endocytosis Response To Unfolded Protein Positive Regulation Of MHC Class I Biosynthetic Process Chaperone Mediated Protein Folding Requiring Cofactor Positive Regulation Of NK T Cell Activation	Cell Morphogenesis In Utero Embryonic Development Cell Volume Homeostasis Apoptotic Process Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Activation Of Signaling Protein Activity Involved In Unfolded Protein Response Hemoglobin Metabolic Process Actin Cytoskeleton Organization Erythrocyte Differentiation Endoplasmic Reticulum Unfolded Protein Response Positive Regulation Of Protein Binding Multicellular Organism Growth Cellular Protein Metabolic Process Positive Regulation Of Angiogenesis Positive Regulation Of Endocytosis Homeostasis Of Number Of Cells Within A Tissue Barbed-end Actin Filament Capping Actin Filament Bundle Assembly Cellular Response To Retinoic Acid
Pathways		Scavenging by Class F Receptors	Apoptotic cleavage of cellular proteins IRE1alpha activates chaperones Programmed Cell Death Apoptotic execution phase Caspase-mediated cleavage of cytoskeletal proteins XBP1(S) activates chaperone genes Unfolded Protein Response (UPR)
Drugs
Diseases
GWAS
Protein-Protein Interactions		14 interactors: ADD1 CFL1 CHD3 CSNK2A1 CSNK2A2 DYNLRB1 HSPA8 PAFAH1B1 PAFAH1B3 PGK1 STK39 TUBA4A UBA1 VAV2	21 interactors: ADD2 ATP1A1 CALM1 CASP3 CSNK2B GEMIN7 HMG20A HSPH1 ID2 ID3 MAP1LC3B PRKACA PRKCD RFX1 ROCK1 SMARCC1 SPTA1 SPTAN1 SPTB TK1 ZDHHC17
Entrez ID		10808	118
HPRD ID		09990	00036
Ensembl ID		ENSG00000120694	ENSG00000087274
Uniprot IDs		B4DYH1 Q92598	A2A3N8 P35611 Q86XM2
PDB IDs
Enriched GO Terms of Interacting Partners?		Axonogenesis Axon Development Cell Morphogenesis Involved In Neuron Differentiation Cell Morphogenesis Neuron Projection Morphogenesis Cell Morphogenesis Involved In Differentiation Axon Guidance Neuron Projection Development Cell Projection Morphogenesis Cell Part Morphogenesis Movement Of Cell Or Subcellular Component Neuron Development Cell Cycle Process Chemotaxis Neuron Differentiation Cell Projection Organization Mitotic Cell Cycle Process Locomotion Mitotic Cell Cycle Cell Cycle Nervous System Development Generation Of Neurons Secretion By Cell Platelet Activation Anatomical Structure Morphogenesis Neurogenesis Cell Differentiation Mitotic Spindle Checkpoint Negative Regulation Of Chromosome Segregation Cytoskeleton Organization Cell Development Regulation Of Mitotic Sister Chromatid Separation Negative Regulation Of Mitotic Nuclear Division Spindle Checkpoint 'de Novo' Posttranslational Protein Folding Secretion Regulation Of Mitotic Metaphase/anaphase Transition 'de Novo' Protein Folding Anatomical Structure Development Regulation Of Cellular Component Organization Chaperone-mediated Protein Folding Protein Folding Negative Regulation Of Fibril Organization Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteasomal Protein Catabolic Process Regulation Of Actin Filament Depolymerization Platelet Degranulation Microtubule-based Process Regulation Of Cellular Component Size Negative Regulation Of Cellular Protein Catabolic Process	Negative Regulation Of Actin Filament Polymerization Response To External Stimulus Negative Regulation Of Protein Polymerization Regulation Of Actin Filament-based Process Regulation Of Binding Nervous System Development Negative Regulation Of Protein Complex Assembly Actin Filament Capping Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Negative Regulation Of Actin Filament Depolymerization Negative Regulation Of Cytoskeleton Organization Regulation Of Actin Filament Polymerization Regulation Of Actin Filament Depolymerization Execution Phase Of Apoptosis Regulation Of Actin Cytoskeleton Organization Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Filament Length System Development Negative Regulation Of Protein Complex Disassembly Vascular Endothelial Growth Factor Receptor Signaling Pathway Response To Stimulus Regulation Of Cell Activation Regulation Of Protein Depolymerization Neuron Differentiation Generation Of Neurons Developmental Process Regulation Of Cytoskeleton Organization Regulation Of Protein Complex Disassembly Multicellular Organismal Development Immune System Process Neurogenesis Anatomical Structure Development Cellular Metabolic Process Regulation Of Protein Binding Regulation Of Cellular Component Size Regulation Of Protein Complex Assembly Chemotaxis Regulation Of Cell Adhesion Activation Of Phospholipase C Activity Anatomical Structure Morphogenesis Regulation Of Cell-cell Adhesion Positive Regulation Of Phospholipase C Activity Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Axon Guidance Cell Morphogenesis Involved In Differentiation Negative Regulation Of Glial Cell Apoptotic Process Neurotrophin TRK Receptor Signaling Pathway Regulation Of Cardiac Muscle Contraction Neurotrophin Signaling Pathway Positive Regulation Of Phospholipase Activity
Tagcloud ?		accordingly aggressive aggressiveness bcl candidacy clarify concurrently confirming delay favors hodgkin injected interacts lymphoma lymphomas myc namalwa nhl nhls oncoproteins paralleled physically positively silenced stabilization tumorigenicity valuable	arnt2 asked camk2g cstb ctgf downregulated dr1 epas1 globin gna11 hif1a hypoxic il6st khsrp mars multitude neuroglobin neuroprotection ngb o4 ogd pea15 r4 reoxygenation rest spatially temporally tg wt
Tagcloud (Difference) ?		accordingly aggressive aggressiveness bcl candidacy clarify concurrently confirming delay favors hodgkin injected interacts lymphoma lymphomas myc namalwa nhl nhls oncoproteins paralleled physically positively silenced stabilization tumorigenicity valuable	arnt2 asked camk2g cstb ctgf downregulated dr1 epas1 globin gna11 hif1a hypoxic il6st khsrp mars multitude neuroglobin neuroprotection ngb o4 ogd pea15 r4 reoxygenation rest spatially temporally tg wt
Tagcloud (Intersection) ?