HSPH1 and UBA1

Number of citations of the paper that reports this interaction (PubMedID 14733918)
0

Data Source:
HPRD (in vitro)

		HSPH1	UBA1
Description		heat shock protein family H (Hsp110) member 1	ubiquitin like modifier activating enzyme 1
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GO Annotations	Cellular Component	Extracellular Region Nucleus Nucleoplasm Cytoplasm Cytosol Microtubule Protein-containing Complex Extracellular Exosome Endocytic Vesicle Lumen	Heterochromatin Nucleus Nucleoplasm Cytoplasm Mitochondrion Lysosomal Membrane Cytosol Endosome Membrane Desmosome Rough Endoplasmic Reticulum Membrane Extracellular Exosome
	Molecular Function	Nucleotide Binding Adenyl-nucleotide Exchange Factor Activity Protein Binding ATP Binding Alpha-tubulin Binding ATP-dependent Protein Folding Chaperone	Nucleotide Binding RNA Binding Ubiquitin Activating Enzyme Activity Protein Binding ATP Binding Ubiquitin-like Modifier Activating Enzyme Activity Ligase Activity
	Biological Process	Protein Folding Response To Unfolded Protein Positive Regulation Of MHC Class I Biosynthetic Process Positive Regulation Of NK T Cell Activation	Ubiquitin-dependent Protein Catabolic Process DNA Damage Response Protein Ubiquitination
Pathways		Scavenging by Class F Receptors Scavenging by Class F Receptors Regulation of HSF1-mediated heat shock response	Synthesis of active ubiquitin: roles of E1 and E2 enzymes Antigen processing: Ubiquitination & Proteasome degradation
Drugs		Phenethyl Isothiocyanate	Hexatantalum Dodecabromide Quercetin
Diseases			Spinal muscular atrophy (SMA), including: SMA type I (SMA1) / Werdning-Hoffman disease; SMA type II (SMA2); SMA type III (SMA3) / Kugeleberg-Welander disease; SMA type IV (SMA4); X-linked SMA 2 (SMAX2); X-linked distal SMA 3 (DSMAX); Distal SMA autosomal recessive type 4 (DSMA4); Congenital distal spinal muscular atrophy (SMAL); SMA proximal adult autosomal dominant (SMAPAD)
GWAS		Metabolite levels ( 23823483)
Interacting Genes		20 interacting genes: ADD1 CEBPA CFL1 CHD3 CSNK2A1 CSNK2A2 DYNLRB1 FNDC3B HSPA13 HSPA8 NEDD8 NMI PAFAH1B1 PAFAH1B3 PGK1 PTEN STK39 TUBA4A UBA1 VAV2	51 interacting genes: ABCF1 AZGP1P2 BUB3 CDK1 CEBPA CHEK1 ECHS1 GAN GRB2 HGS HSPH1 LINC01554 MGMT MTNR1A OGT PIAS3 SEMA3F SMAD5 SUMO2 TAF9 TMCC2 TSSC4 TTC19 UBC UBE2A UBE2B UBE2C UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2G1 UBE2J1 UBE2J2 UBE2K UBE2L1 UBE2L3 UBE2L6 UBE2M UBE2N UBE2Q2 UBE2R2 UBE2S UBE2T UBE2U UBE2W UBE2Z UBTD2
Entrez ID		10808	7317
HPRD ID		09990	02440
Ensembl ID		ENSG00000120694	ENSG00000130985
Uniprot IDs		A0A0A0MSM0 B4DY72 Q92598	A0A024R1A3 P22314
PDB IDs		6GFA	4P22 6DC6 7PYV
Enriched GO Terms of Interacting Partners?		Regulation Of Proteolysis Regulation Of Cell Size Protein Kinase CK2 Complex 1-alkyl-2-acetylglycerophosphocholine Esterase Complex Cytoplasm Regulation Of Cellular Component Size Cytosol Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Cell Size Nucleotide Binding ATP Binding Protein Targeting To Vacuole Involved In Autophagy Microtubule Cytoskeleton Organization Positive Regulation Of Embryonic Development Cellular Response To Stress Microtubule-based Process PML Body PcG Protein Complex Protein Refolding Negative Regulation Of Cellular Component Organization Negative Regulation Of Supramolecular Fiber Organization Cytoskeleton Organization Negative Regulation Of Actin Filament Depolymerization Cellular Response To Metal Ion Protein Heterodimerization Activity Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Regulation Of Protein Metabolic Process Cofilin-actin Rod Negative Regulation Of Unidimensional Cell Growth Regulation Of Dendritic Spine Morphogenesis Positive Regulation Of Cell Growth Positive Regulation Of Dendritic Spine Development Regulation Of Postsynapse Organization Positive Regulation Of Establishment Of Cell Polarity Regulating Cell Shape Protein Depolymerization Positive Regulation Of Barbed-end Actin Filament Capping Negative Regulation Of Cell Projection Organization Positive Regulation Of Protein Localization To Cell Leading Edge Protein Serine Kinase Activity Protein Serine/threonine Kinase Activity Chaperone-mediated Autophagy Translocation Complex Disassembly ATP-dependent Protein Folding Chaperone Dynein Intermediate Chain Binding Central Nervous System Neuron Axonogenesis Phosphoglycerate Kinase Activity Negative Regulation Of Synaptic Vesicle Clustering Positive Regulation Of Sodium Ion Import Across Plasma Membrane Response To Stress Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process	Ubiquitin Conjugating Enzyme Activity Protein Polyubiquitination Protein Modification By Small Protein Conjugation Post-translational Protein Modification Ubiquitin-protein Transferase Activity Protein Ubiquitination Protein K48-linked Ubiquitination Ubiquitin-like Protein Transferase Activity Protein Modification Process Protein K11-linked Ubiquitination Modification-dependent Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process ATP Binding Transferase Activity Ubiquitin-dependent Protein Catabolic Process Nucleotide Binding Protein Metabolic Process Macromolecule Catabolic Process Proteolysis Ubiquitin Protein Ligase Binding Protein Monoubiquitination Macromolecule Metabolic Process Catabolic Process Protein K63-linked Ubiquitination Proteasomal Protein Catabolic Process Protein K6-linked Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein Catabolic Process Nucleoplasm ISG15 Transferase Activity HULC Complex DNA Damage Response ISG15-protein Conjugation Regulation Of Post-translational Protein Modification Free Ubiquitin Chain Polymerization Nucleus DNA Repair Positive Regulation Of Post-translational Protein Modification Protein K29-linked Ubiquitination Cellular Response To Stress Cell Cycle Phase Transition Ubiquitin Binding Regulation Of Protein Modification Process Protein K27-linked Ubiquitination Positive Regulation Of Protein Ubiquitination Ubiquitin Ligase Complex Positive Regulation Of Protein Metabolic Process Regulation Of Protein Ubiquitination TORC1 Signaling DNA Metabolic Process
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