HSPH1 and PAFAH1B1

Number of citations of the paper that reports this interaction (PubMedID 14733918)
0

Data Source:
HPRD (in vitro)

		HSPH1	PAFAH1B1
Description		heat shock protein family H (Hsp110) member 1	platelet activating factor acetylhydrolase 1b regulatory subunit 1
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GO Annotations	Cellular Component	Extracellular Region Nucleus Nucleoplasm Cytoplasm Cytosol Microtubule Protein-containing Complex Extracellular Exosome Endocytic Vesicle Lumen	Astral Microtubule Kinetochore Nucleus Nuclear Envelope Cytoplasm Centrosome Spindle Cytosol Cytoskeleton Kinesin Complex Microtubule Microtubule Associated Complex Cytoplasmic Microtubule Cell Cortex 1-alkyl-2-acetylglycerophosphocholine Esterase Complex Microtubule Cytoskeleton Membrane Axon Growth Cone Cell Leading Edge Motile Cilium Nuclear Membrane Vesicle Stereocilium Neuron Projection Neuronal Cell Body Perinuclear Region Of Cytoplasm Extracellular Exosome Central Region Of Growth Cone Schaffer Collateral - CA1 Synapse Glutamatergic Synapse Axon Cytoplasm
	Molecular Function	Nucleotide Binding Adenyl-nucleotide Exchange Factor Activity Protein Binding ATP Binding Alpha-tubulin Binding ATP-dependent Protein Folding Chaperone	Protein Binding Microtubule Binding Heparin Binding Dynactin Binding Identical Protein Binding Phospholipase Binding Protein-containing Complex Binding Dynein Intermediate Chain Binding Protein Heterodimerization Activity Microtubule Plus-end Binding Phosphoprotein Binding Dynein Complex Binding
	Biological Process	Protein Folding Response To Unfolded Protein Positive Regulation Of MHC Class I Biosynthetic Process Positive Regulation Of NK T Cell Activation	Establishment Of Mitotic Spindle Orientation Microtubule Cytoskeleton Organization Ameboidal-type Cell Migration Acrosome Assembly Neuron Migration Positive Regulation Of Cytokine-mediated Signaling Pathway Lipid Metabolic Process Microtubule-based Process Nuclear Migration JNK Cascade Chemical Synaptic Transmission Germ Cell Development Nervous System Development Neuroblast Proliferation Learning Or Memory Retrograde Axonal Transport Adult Locomotory Behavior Protein Secretion Negative Regulation Of Neuron Projection Development Lipid Catabolic Process Cell Migration Stem Cell Division Transmission Of Nerve Impulse Corpus Callosum Morphogenesis Hippocampus Development Layer Formation In Cerebral Cortex Cerebral Cortex Neuron Differentiation Cerebral Cortex Development Actin Cytoskeleton Organization Cell Differentiation Forebrain Development Microtubule Organizing Center Organization Osteoclast Development Reelin-mediated Signaling Pathway Positive Regulation Of Embryonic Development Establishment Of Planar Polarity Of Embryonic Epithelium Cortical Microtubule Organization Positive Regulation Of Axon Extension Positive Regulation Of Mitotic Cell Cycle Negative Regulation Of JNK Cascade Platelet Activating Factor Metabolic Process Vesicle Transport Along Microtubule Brain Morphogenesis Modulation Of Chemical Synaptic Transmission Neuromuscular Process Controlling Balance Microtubule Sliding Nuclear Membrane Disassembly Positive Regulation Of Cellular Component Organization Cell Division Establishment Of Localization In Cell Establishment Of Organelle Localization Establishment Of Centrosome Localization Maintenance Of Centrosome Location Auditory Receptor Cell Development Positive Regulation Of Dendritic Spine Morphogenesis Regulation Of Microtubule Cytoskeleton Organization Cochlea Development Microtubule Cytoskeleton Organization Involved In Establishment Of Planar Polarity Myeloid Leukocyte Migration Regulation Of Postsynapse Organization Radial Glia-guided Pyramidal Neuron Migration Interneuron Migration
Pathways		Scavenging by Class F Receptors Scavenging by Class F Receptors Regulation of HSF1-mediated heat shock response	Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane RHO GTPases Activate Formins COPI-independent Golgi-to-ER retrograde traffic Mitotic Prometaphase AURKA Activation by TPX2 EML4 and NUDC in mitotic spindle formation
Drugs		Phenethyl Isothiocyanate
Diseases			Lissencephaly (LIS); Miller-Dieker syndrome (MDLS)
GWAS		Metabolite levels ( 23823483)	Adverse response to drug ( 30420678) Anxiety ( 33859377) Depression ( 33859377) Mean platelet volume ( 32888494) Neurociticism ( 29500382) Neuroticism ( 27089181) Self-reported tiredness ( 28194004)
Interacting Genes		20 interacting genes: ADD1 CEBPA CFL1 CHD3 CSNK2A1 CSNK2A2 DYNLRB1 FNDC3B HSPA13 HSPA8 NEDD8 NMI PAFAH1B1 PAFAH1B3 PGK1 PTEN STK39 TUBA4A UBA1 VAV2	26 interacting genes: CLIP1 CRYAA CSNK2A1 CUL4A CUL4B DAB1 DCTN1 DCTN2 DCX DNAI1 FBXO7 HSPH1 KARS1 KATNA1 KATNB1 MAP1B MAP2 NDE1 NDEL1 NUDC PAFAH1B2 PAFAH1B3 PDE4D SLC25A21-AS1 TNIK TUBA1A
Entrez ID		10808	5048
HPRD ID		09990	03329
Ensembl ID		ENSG00000120694	ENSG00000007168
Uniprot IDs		A0A0A0MSM0 B4DY72 Q92598	A0A6Q8PFT2 A0A6Q8PFU3 P43034
PDB IDs		6GFA	7MT1 8DYU 8DYV 8FDT 8FDU 8PQW 8PQY 8PQZ 8PTK
Enriched GO Terms of Interacting Partners?		Regulation Of Proteolysis Regulation Of Cell Size Protein Kinase CK2 Complex 1-alkyl-2-acetylglycerophosphocholine Esterase Complex Cytoplasm Regulation Of Cellular Component Size Cytosol Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Cell Size Nucleotide Binding ATP Binding Protein Targeting To Vacuole Involved In Autophagy Microtubule Cytoskeleton Organization Positive Regulation Of Embryonic Development Cellular Response To Stress Microtubule-based Process PML Body PcG Protein Complex Protein Refolding Negative Regulation Of Cellular Component Organization Negative Regulation Of Supramolecular Fiber Organization Cytoskeleton Organization Negative Regulation Of Actin Filament Depolymerization Cellular Response To Metal Ion Protein Heterodimerization Activity Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Regulation Of Protein Metabolic Process Cofilin-actin Rod Negative Regulation Of Unidimensional Cell Growth Regulation Of Dendritic Spine Morphogenesis Positive Regulation Of Cell Growth Positive Regulation Of Dendritic Spine Development Regulation Of Postsynapse Organization Positive Regulation Of Establishment Of Cell Polarity Regulating Cell Shape Protein Depolymerization Positive Regulation Of Barbed-end Actin Filament Capping Negative Regulation Of Cell Projection Organization Positive Regulation Of Protein Localization To Cell Leading Edge Protein Serine Kinase Activity Protein Serine/threonine Kinase Activity Chaperone-mediated Autophagy Translocation Complex Disassembly ATP-dependent Protein Folding Chaperone Dynein Intermediate Chain Binding Central Nervous System Neuron Axonogenesis Phosphoglycerate Kinase Activity Negative Regulation Of Synaptic Vesicle Clustering Positive Regulation Of Sodium Ion Import Across Plasma Membrane Response To Stress Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process	Microtubule Microtubule Cytoskeleton Organization Microtubule-based Process Microtubule Binding Cytoskeleton Cytoskeleton Organization Microtubule Associated Complex Organelle Localization Cytosol Cytoplasm Neuron Migration Establishment Of Organelle Localization Chromosome Localization Centrosome Regulation Of Microtubule Polymerization Or Depolymerization Organelle Organization Microtubule-based Transport Spindle Nervous System Development Microtubule-based Movement Microtubule Cytoskeleton Organization Involved In Mitosis Microtubule Cytoskeleton Neuron Projection Morphogenesis Regulation Of Neuron Projection Development Regulation Of Microtubule Polymerization Cell Projection Morphogenesis Regulation Of Microtubule Cytoskeleton Organization Kinetochore Transport Along Microtubule Platelet-activating Factor Acetyltransferase Activity 1-alkyl-2-acetylglycerophosphocholine Esterase Complex Organelle Transport Along Microtubule Cytoskeleton-dependent Intracellular Transport Protein Heterodimerization Activity Positive Regulation Of Microtubule Polymerization Establishment Of Vesicle Localization Dynein Complex Establishment Of Mitotic Spindle Orientation Basal Dendrite Katanin Complex Radial Glia-guided Pyramidal Neuron Migration Establishment Of Mitotic Spindle Localization Vesicle Localization Mitotic Centrosome Separation Regulation Of Plasma Membrane Bounded Cell Projection Organization Dendrite Development Establishment Of Spindle Orientation Negative Regulation Of Microtubule Polymerization Or Depolymerization Regulation Of Microtubule-based Process Axon Hillock
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