HSPH1 and VAV2

Number of citations of the paper that reports this interaction (PMID 18654987)
7

Data Source:
BioGRID (two hybrid)

		HSPH1	VAV2
Gene Name		heat shock 105kDa/110kDa protein 1	vav 2 guanine nucleotide exchange factor
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Nucleoplasm Cytoplasm Cytosol Microtubule Extracellular Vesicular Exosome Endocytic Vesicle Lumen	Cytosol Plasma Membrane
	Molecular Function	Protein Binding ATP Binding Alpha-tubulin Binding	Guanyl-nucleotide Exchange Factor Activity Rho Guanyl-nucleotide Exchange Factor Activity Epidermal Growth Factor Receptor Binding Protein Binding Metal Ion Binding
	Biological Process	Receptor-mediated Endocytosis Response To Unfolded Protein Positive Regulation Of MHC Class I Biosynthetic Process Chaperone Mediated Protein Folding Requiring Cofactor Positive Regulation Of NK T Cell Activation	Angiogenesis Signal Transduction Small GTPase Mediated Signal Transduction Axon Guidance Blood Coagulation Regulation Of Gene Expression Cell Migration Lamellipodium Assembly Platelet Activation Regulation Of Blood Coagulation Positive Regulation Of Rho GTPase Activity Fc-epsilon Receptor Signaling Pathway Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Positive Regulation Of Apoptotic Process Positive Regulation Of Phosphatidylinositol 3-kinase Activity Innate Immune Response Vascular Endothelial Growth Factor Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Ephrin Receptor Signaling Pathway Regulation Of Small GTPase Mediated Signal Transduction Apoptotic Signaling Pathway
Pathways		Scavenging by Class F Receptors	Signaling by GPCR Axon guidance L1CAM interactions FCERI mediated MAPK activation VEGFA-VEGFR2 Pathway Rho GTPase cycle DAP12 signaling EPH-ephrin mediated repulsion of cells VEGFR2 mediated vascular permeability EPH-Ephrin signaling G alpha (12/13) signalling events Fcgamma receptor (FCGR) dependent phagocytosis Regulation of actin dynamics for phagocytic cup formation Innate Immune System Signalling by NGF DAP12 interactions Signal transduction by L1 Cell death signalling via NRAGE, NRIF and NADE p75 NTR receptor-mediated signalling GPCR downstream signaling Signaling by VEGF NRAGE signals death through JNK Signaling by Rho GTPases GPVI-mediated activation cascade Fc epsilon receptor (FCERI) signaling FCERI mediated Ca+2 mobilization Platelet activation, signaling and aggregation
Drugs
Diseases
GWAS			Multiple sclerosis ( 20598377) vWF and FVIII levels ( 21810271)
Protein-Protein Interactions		14 interactors: ADD1 CFL1 CHD3 CSNK2A1 CSNK2A2 DYNLRB1 HSPA8 PAFAH1B1 PAFAH1B3 PGK1 STK39 TUBA4A UBA1 VAV2	62 interactors: ARIH1 BIRC6 BOD1L1 BRDT BZW1 CBL CBLB CCNO CCT2 CCT3 CD19 CD44 CEP170 CHMP3 CRCP DCUN1D4 DNAJC21 EGFR EIF4G3 EPHB2 ERBB2 ERBB3 FNTA FUCA1 FYN GAPVD1 GRB2 HNRNPF HSPH1 IPO4 MARCH7 MED21 MRGBP NCKAP5 NEK3 PHF10 PNMA1 POGZ PPM1B PRLR RAC1 RAD23A RBBP6 RHOA RHOG SERBP1 SF3A3 SH3BP2 SNW1 SOCS1 SRPK2 SRRT ST13 STK24 SYK TARBP2 TCP11 TOM1L1 TTN UBE4B USP38 VCPIP1
Entrez ID		10808	7410
HPRD ID		09990	02694
Ensembl ID		ENSG00000120694	ENSG00000160293
Uniprot IDs		B4DYH1 Q92598	P52735
PDB IDs			2DLZ 2DM1 2LNW 2LNX
Enriched GO Terms of Interacting Partners?		Axonogenesis Axon Development Cell Morphogenesis Involved In Neuron Differentiation Cell Morphogenesis Neuron Projection Morphogenesis Cell Morphogenesis Involved In Differentiation Axon Guidance Neuron Projection Development Cell Projection Morphogenesis Cell Part Morphogenesis Movement Of Cell Or Subcellular Component Neuron Development Cell Cycle Process Chemotaxis Neuron Differentiation Cell Projection Organization Mitotic Cell Cycle Process Locomotion Mitotic Cell Cycle Cell Cycle Nervous System Development Generation Of Neurons Secretion By Cell Platelet Activation Anatomical Structure Morphogenesis Neurogenesis Cell Differentiation Mitotic Spindle Checkpoint Negative Regulation Of Chromosome Segregation Cytoskeleton Organization Cell Development Regulation Of Mitotic Sister Chromatid Separation Negative Regulation Of Mitotic Nuclear Division Spindle Checkpoint 'de Novo' Posttranslational Protein Folding Secretion Regulation Of Mitotic Metaphase/anaphase Transition 'de Novo' Protein Folding Anatomical Structure Development Regulation Of Cellular Component Organization Chaperone-mediated Protein Folding Protein Folding Negative Regulation Of Fibril Organization Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteasomal Protein Catabolic Process Regulation Of Actin Filament Depolymerization Platelet Degranulation Microtubule-based Process Regulation Of Cellular Component Size Negative Regulation Of Cellular Protein Catabolic Process	Cellular Protein Metabolic Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cellular Response To Fibroblast Growth Factor Stimulus Enzyme Linked Receptor Protein Signaling Pathway Response To Fibroblast Growth Factor Phosphatidylinositol-mediated Signaling Cellular Response To Organic Substance Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Fc-epsilon Receptor Signaling Pathway Regulation Of Protein Metabolic Process Cellular Response To Growth Factor Stimulus Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Response To Growth Factor Response To Organic Substance Peptidyl-tyrosine Phosphorylation Fc Receptor Signaling Pathway Platelet Activation Innate Immune Response Regulation Of Cellular Protein Metabolic Process Cellular Protein Modification Process Cellular Metabolic Process Protein Metabolic Process Positive Regulation Of Viral Process Regulation Of Body Fluid Levels Wound Healing Immune Response Regulation Of Cell Adhesion Regulation Of Cell-cell Adhesion Immune Response-regulating Cell Surface Receptor Signaling Pathway Axon Guidance Cell Activation Regulation Of Signal Transduction Response To Wounding Regulation Of Signaling Intracellular Signal Transduction Regulation Of T Cell Activation Viral Process Positive Regulation Of Signal Transduction Blood Coagulation Cell Surface Receptor Signaling Pathway Hemostasis Protein Ubiquitination Regulation Of Immune System Process Signal Transduction Regulation Of Intracellular Signal Transduction Chemotaxis Positive Regulation Of Homotypic Cell-cell Adhesion
Tagcloud ?		accordingly aggressive aggressiveness bcl candidacy clarify concurrently confirming delay favors hodgkin injected interacts lymphoma lymphomas myc namalwa nhl nhls oncoproteins paralleled physically positively silenced stabilization tumorigenicity valuable	calm3 cblb ccna2 ccnd3 cdk6 cited1 dems dok elk3 fyn git1 hck lck module modules nonmodule p85beta pdgfra pib5pa psd93 ptch2 sam68 sh3kbp1 shc tgfbr1 tgfbr2 wilcoxon yes zfyve9
Tagcloud (Difference) ?		accordingly aggressive aggressiveness bcl candidacy clarify concurrently confirming delay favors hodgkin injected interacts lymphoma lymphomas myc namalwa nhl nhls oncoproteins paralleled physically positively silenced stabilization tumorigenicity valuable	calm3 cblb ccna2 ccnd3 cdk6 cited1 dems dok elk3 fyn git1 hck lck module modules nonmodule p85beta pdgfra pib5pa psd93 ptch2 sam68 sh3kbp1 shc tgfbr1 tgfbr2 wilcoxon yes zfyve9
Tagcloud (Intersection) ?