DCD and APPBP2

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		DCD	APPBP2
Description		dermcidin	amyloid beta precursor protein binding protein 2
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Membrane Extrinsic Component Of Membrane Extracellular Exosome	Nucleus Nucleoplasm Cytoplasm Cytoskeleton Microtubule Microtubule Associated Complex Membrane Cytoplasmic Vesicle Membrane Cul2-RING Ubiquitin Ligase Complex
	Molecular Function	RNA Binding Monoatomic Ion Channel Activity Monoatomic Anion Channel Activity Protein Binding Peptidase Activity Lipid Binding Hydrolase Activity Metal Ion Binding	Microtubule Motor Activity Protein Binding Ubiquitin-like Ligase-substrate Adaptor Activity
	Biological Process	Proteolysis Inorganic Anion Transport Killing Of Cells Of Another Organism Monoatomic Ion Transmembrane Transport Defense Response To Bacterium Defense Response To Gram-negative Bacterium Defense Response To Gram-positive Bacterium Defense Response To Fungus Killing By Host Of Symbiont Cells Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Monoatomic Anion Transmembrane Transport	Intracellular Protein Transport Protein Transport Protein Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Intracellular Transport
Pathways		Antimicrobial peptides
Drugs		Zinc Zinc acetate Zinc chloride Zinc sulfate, unspecified form
Diseases
GWAS		Type 2 diabetes ( 18372903)	Interleukin-6 levels ( 33517400) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Waist-hip ratio ( 28552196)
Interacting Genes		8 interacting genes: APPBP2 ASPH CEBPA FOXP1 HSP90AA1 IL24 SUMO2 USP7	122 interacting genes: - AADAC ACTN1 AHCY AIM2 AK3 ALDH1L1 ANKRD10 APP AR ARMCX5 ASCC3 ATP13A1 BCL7A BIN2 C1orf50 CALM3 CCDC167 CCDC85C CCNL1 CDK16 CHMP5 CIBAR1 CLCN1 CNTFR COL24A1 CORO2B CREB3 CSNK1G2 CST2 CTC1 CYBA DCD DHRS2 DHX16 DOLK DPEP1 DPYS EID3 ERO1A FAM107A FSTL1 FXYD7 GALNT3 GCSAM GP9 GPRC5C GSTP1 H2AC15 HGFAC HIPK4 HSD3B7 HSPA4 ITGB4 ITGB5 KHK KIF6 KLF11 KLHL35 LANCL2 LONRF3 LUC7L2 LUZP4 MAN2B2 MCOLN1 MGAT4B MLLT3 MMP28 MRPL28 MSH2 MSLN MUL1 MYLK NFYA NHERF1 NPRL3 PCSK5 PEX39 PI4KAP2 PNPLA5 PPIL6 PPP1R8 PRKAA2 PRKACB PSAP PTCH1 PYROXD2 RAB7B RASSF5 RHEB RILPL1 RNF128 RNF34 RNGTT RRS1 SELENOI SELENOV SLC22A6 SLC25A23 SLC33A2 SLC7A10 SNX5 SPDYE2 SPDYE2B ST8SIA5 SYNRG SYT11 TAF11 TAFA4 TBL3 TCF25 TNP2 TRMT2A UBE2R2 UGGT2 WAS WDR24 WFIKKN1 WNT5B ZC3H10 ZCCHC12 ZNF747
Entrez ID		117159	10513
HPRD ID		07363	05616
Ensembl ID		ENSG00000161634	ENSG00000062725
Uniprot IDs		P81605	Q92624
PDB IDs		2KSG 2NDK 2YMK 6SHK	8JAL 8JAQ 8JAR 8JAS 8JAU 8JAV
Enriched GO Terms of Interacting Partners?		Regulation Of Proteolysis Regulation Of Protein Catabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteolysis Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Catabolic Process Positive Regulation Of Protein Catabolic Process Regulation Of Muscle System Process Regulation Of Intracellular Transport Regulation Of Protein Metabolic Process Positive Regulation Of Protein Metabolic Process RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding CTP Binding DATP Binding Regulation Of Protein Stability Peptidyl-aspartic Acid 3-dioxygenase Activity Regulation Of Cardiac Muscle Contraction Positive Regulation Of Intracellular Protein Transport Regulation Of Striated Muscle Contraction Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Cellular Response To Tumor Necrosis Factor Cellular Response To Cytokine Stimulus Response To Vitamin B2 C/EBP Complex Neurofibrillary Tangle Assembly UTP Binding Sulfonylurea Receptor Binding Positive Regulation Of Interleukin-21 Production Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Telomere Maintenance PML Body Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Positive Regulation Of Metabolic Process Regulation Of Cellular Localization CHOP-C/EBP Complex Response To Tumor Necrosis Factor Positive Regulation Of Proteasomal Protein Catabolic Process Rho GDP-dissociation Inhibitor Binding Symbiont-mediated Disruption Of Host Cell PML Body Regulation Of Establishment Of Protein Localization Transmembrane Transporter Binding Positive Regulation Of Intracellular Transport Regulation Of System Process Response To Peptide Histone Deacetylase Binding Response To Cytokine Positive Regulation Of Proteolysis Involved In Protein Catabolic Process White Fat Cell Proliferation Regulation Of Intracellular Protein Transport	Protein Binding
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