ARPC3 and LGALS4

Number of citations: 0 (PubMedID 16169070)
Data Source: BioGRID (two hybrid), HPRD (two hybrid)

		ARPC3	LGALS4
Name		actin related protein 2/3 complex subunit 3	galectin 4
Structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Cytoskeleton Arp2/3 Protein Complex Focal Adhesion Actin Cytoskeleton Membrane Lamellipodium Cell Leading Edge Filamentous Actin Site Of Double-strand Break Cell Projection Growth Cone Leading Edge Extracellular Exosome	Extracellular Space Cytosol Plasma Membrane Extracellular Matrix
	Molecular Function	Actin Binding Structural Constituent Of Cytoskeleton Protein Binding Actin Filament Binding	Protein Binding Galactoside Binding Carbohydrate Binding
	Biological Process	Regulation Of Actin Filament Polymerization Arp2/3 Complex-mediated Actin Nucleation Actin Polymerization-dependent Cell Motility Regulation Of Synaptic Vesicle Endocytosis Cellular Response To Nerve Growth Factor Stimulus	Antibacterial Peptide Biosynthetic Process Cell Adhesion Defense Response To Bacterium
Pathways		Regulation of actin dynamics for phagocytic cup formation Regulation of actin dynamics for phagocytic cup formation EPHB-mediated forward signaling RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate WASPs and WAVEs Clathrin-mediated endocytosis FCGR3A-mediated phagocytosis FCGR3A-mediated phagocytosis	None
Drugs		N-[2-(2-methyl-1H-indol-3-yl)ethyl]thiophene-2-carboxamide (2S)-2-(3-bromophenyl)-3-(5-chloro-2-hydroxyphenyl)-1,3-thiazolidin-4-one	None
GWAS		Automobile speeding propensity ( 30643258 ) Bipolar disorder ( 31043756 ) Femoral neck bone mineral density ( 30172743 )	Blood protein levels ( 30072576 ) Logical memory (immediate recall) in mild cognitive impairment ( 29274321 )
Novel Interactors		2 novel interactors: SRPK2 WASHC4	None recorded
Interacting Genes		31 interacting genes: ACTR3 ARAP1 ARPC4 BAG6 CCR10 CDKN2B CEBPA CETP DUSP29 EFTUD2 FAM9A GOLGA2 HOXA3 LATS1 LGALS4 LTA4H MAPK6 NRIP1 OTUD5 POU2F1 PRMT1 RBBP8NL RETREG3 RPS4X SYBU TARS3 THNSL2 WAS WASF2 WASL ZNF576	18 interacting genes: ARPC3 BANP CDPF1 CEP55 EYA2 GOLGA6L9 HOMEZ HOXA1 HSF2BP KIAA1549 KRTAP11-1 MLH1 NCKIPSD OSGEP RFX6 RRAS2 TENM4 TOX2
Entrez ID		10094	3960
HPRD ID		09175	03949
Ensembl ID		ENSG00000111229	ENSG00000171747
Uniprot IDs		O15145	P56470 Q6FHZ4
PDB IDs		6UHC 6YW6 6YW7 8P94	1X50 4XZP 4YLZ 4YM0 4YM1 4YM2 4YM3 5CBL 5DUU 5DUV 5DUW 5DUX 6WAB
GO Terms Enriched among Interactors		Regulation Of Cell Projection Assembly Negative Regulation Of Actin Filament Bundle Assembly Actin Filament Polymerization Regulation Of Lamellipodium Assembly Negative Regulation Of Stress Fiber Assembly Positive Regulation Of Plasma Membrane Bounded Cell Projection Assembly Regulation Of Actin Filament Organization Actin Filament Organization Regulation Of Lamellipodium Organization Arp2/3 Protein Complex Actin Polymerization Or Depolymerization Actin Cytoskeleton Actin Filament-based Movement HMG Box Domain Binding Asymmetric Cell Division Protein Polymerization Regulation Of Actin Cytoskeleton Organization Nucleus Arp2/3 Complex-mediated Actin Nucleation Positive Regulation Of Cell Projection Organization Actin Binding Regulation Of Actin Filament-based Process Regulation Of Stress Fiber Assembly Regulation Of Supramolecular Fiber Organization Site Of Double-strand Break	None