ARPC3 and ACTR3

Number of citations of the paper that reports this interaction (PMID 11741539)
47

Data Source:
BioGRID (biochemical)
HPRD (in vivo, in vitro)

		ARPC3	ACTR3
Gene Name		actin related protein 2/3 complex, subunit 3, 21kDa	ARP3 actin-related protein 3 homolog (yeast)
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol Arp2/3 Protein Complex Focal Adhesion Actin Cytoskeleton Membrane Lamellipodium Extracellular Vesicular Exosome	Golgi Membrane Podosome Cytosol Actin Filament Arp2/3 Protein Complex Cell-cell Junction Focal Adhesion Actin Cytoskeleton Membrane Lamellipodium Hemidesmosome Excitatory Synapse Extracellular Vesicular Exosome
	Molecular Function	Structural Constituent Of Cytoskeleton Protein Binding Actin Filament Binding	Structural Constituent Of Cytoskeleton Protein Binding ATP Binding Actin Filament Binding
	Biological Process	Movement Of Cell Or Subcellular Component Axon Guidance Arp2/3 Complex-mediated Actin Nucleation Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Innate Immune Response Ephrin Receptor Signaling Pathway	Movement Of Cell Or Subcellular Component Establishment Or Maintenance Of Cell Polarity Axon Guidance Asymmetric Cell Division Response To Carbohydrate Positive Regulation Of Lamellipodium Assembly Meiotic Chromosome Movement Towards Spindle Pole Meiotic Cytokinesis Arp2/3 Complex-mediated Actin Nucleation Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Regulation Of Myosin II Filament Organization Innate Immune Response Response To Antibiotic Ephrin Receptor Signaling Pathway Positive Regulation Of Dendrite Morphogenesis Positive Regulation Of Filopodium Assembly Spindle Localization Cilium Morphogenesis
Pathways		EPHB-mediated forward signaling Axon guidance EPH-Ephrin signaling Fcgamma receptor (FCGR) dependent phagocytosis Regulation of actin dynamics for phagocytic cup formation Innate Immune System	EPHB-mediated forward signaling Axon guidance EPH-Ephrin signaling Fcgamma receptor (FCGR) dependent phagocytosis Regulation of actin dynamics for phagocytic cup formation Innate Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		20 interactors: ACTR3 ARAP1 ARPC4 BAG6 CDKN2B CETP EFTUD2 GOLGA2 HOXA3 LGALS4 LTA4H MAPK6 NRIP1 OTUD5 PRMT1 RPS4X THNSL2 WAS WASF2 WASL	13 interactors: ACTR2 ARPC2 ARPC3 ARPC4 ARPC5 CDC42 CDH1 CTTN HCLS1 JUND WASF2 WASF3 WASL
Entrez ID		10094	10096
HPRD ID		09175	05024
Ensembl ID		ENSG00000111229	ENSG00000115091
Uniprot IDs		O15145	B4DXW1 P61158
PDB IDs
Enriched GO Terms of Interacting Partners?		Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Regulation Of Actin Cytoskeleton Organization Regulation Of Actin Filament-based Process Phagocytosis Regulation Of Cytoskeleton Organization Fc Receptor Signaling Pathway Regulation Of Cell Projection Assembly Immune Response-activating Cell Surface Receptor Signaling Pathway Positive Regulation Of Filopodium Assembly Actin Filament Organization Positive Regulation Of Cellular Component Biogenesis Actin Cytoskeleton Organization Regulation Of Filopodium Assembly Actin Filament-based Process Immune Response-regulating Cell Surface Receptor Signaling Pathway Endocytosis Positive Regulation Of Arp2/3 Complex-mediated Actin Nucleation Positive Regulation Of Actin Nucleation Actin Filament-based Movement Positive Regulation Of Cytoskeleton Organization Immune System Process Immune Response-regulating Signaling Pathway Innate Immune Response Negative Regulation Of Stress Fiber Assembly Actin Polymerization Or Depolymerization Negative Regulation Of Actin Filament Bundle Assembly Positive Regulation Of Lamellipodium Assembly Defense Response Cell Cycle Regulation Of Organelle Organization Ephrin Receptor Signaling Pathway Positive Regulation Of Cell Projection Organization Positive Regulation Of Lamellipodium Organization Regulation Of Arp2/3 Complex-mediated Actin Nucleation Positive Regulation Of Immune Response Megakaryocyte Differentiation Regulation Of Actin Nucleation Regulation Of Lamellipodium Assembly Cytoskeleton Organization Positive Regulation Of Organelle Organization Immune Response Arp2/3 Complex-mediated Actin Nucleation Regulation Of Immune System Process Regulation Of Immune Response Actin Filament Polymerization Regulation Of Cell Projection Organization Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Immune System Process	Actin Filament Organization Actin Cytoskeleton Organization Actin Filament-based Process Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Regulation Of Cytoskeleton Organization Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Positive Regulation Of Cellular Component Biogenesis Regulation Of Organelle Organization Regulation Of Actin Cytoskeleton Organization Positive Regulation Of Cytoskeleton Organization Ephrin Receptor Signaling Pathway Regulation Of Actin Filament-based Process Cytoskeleton Organization Phagocytosis Cell Projection Organization Fc Receptor Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Cell Development Regulation Of Cellular Component Organization Regulation Of Protein Complex Assembly Regulation Of Actin Filament Polymerization Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Filament Length Immune Response-regulating Cell Surface Receptor Signaling Pathway Endocytosis Arp2/3 Complex-mediated Actin Nucleation Positive Regulation Of Organelle Organization Positive Regulation Of Actin Filament Polymerization Cell Morphogenesis Cell Differentiation Positive Regulation Of Protein Polymerization Immune Response-regulating Signaling Pathway Neuron Projection Development Cell Projection Morphogenesis Actin Nucleation Regulation Of Immune System Process Cell Part Morphogenesis Regulation Of Immune Response Positive Regulation Of Immune System Process Regulation Of Cellular Component Size Positive Regulation Of Protein Complex Assembly Neuron Development Positive Regulation Of Immune Response Neuron Projection Morphogenesis Organelle Organization Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Axon Guidance Actin Polymerization Or Depolymerization Neurogenesis
Tagcloud ?		aberrant coincident collective combinatorial computational concurrently consider cytoskeleton dysregulated enriched extensive focal metastasis metastatic microrna micrornas mounting nodes notable numerous organization perturbed rankl repression reveals summary tgfb1 transcripts upstream	actb anxa2 anxa6 canine cope dedifferentiation grade histologically hspa9 interesting kit mast mct mcts mutational noteworthy observable oncology paradox pdia3 proliferating proteome reflected tcp1a tcp1e transferrin tryptase tumours wdr1
Tagcloud (Difference) ?		aberrant coincident collective combinatorial computational concurrently consider cytoskeleton dysregulated enriched extensive focal metastasis metastatic microrna micrornas mounting nodes notable numerous organization perturbed rankl repression reveals summary tgfb1 transcripts upstream	actb anxa2 anxa6 canine cope dedifferentiation grade histologically hspa9 interesting kit mast mct mcts mutational noteworthy observable oncology paradox pdia3 proliferating proteome reflected tcp1a tcp1e transferrin tryptase tumours wdr1
Tagcloud (Intersection) ?