ARPC3 and TARS3

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		ARPC3	TARS3
Description		actin related protein 2/3 complex subunit 3	threonyl-tRNA synthetase 3
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Cytoskeleton Arp2/3 Protein Complex Focal Adhesion Actin Cytoskeleton Membrane Lamellipodium Cell Leading Edge Filamentous Actin Site Of Double-strand Break Cell Projection Growth Cone Leading Edge Extracellular Exosome	Nucleus Cytoplasm
	Molecular Function	Actin Binding Structural Constituent Of Cytoskeleton Protein Binding Actin Filament Binding	Nucleotide Binding Aminoacyl-tRNA Ligase Activity Threonine-tRNA Ligase Activity Protein Binding ATP Binding Ligase Activity
	Biological Process	Regulation Of Actin Filament Polymerization Arp2/3 Complex-mediated Actin Nucleation Actin Polymerization-dependent Cell Motility Regulation Of Synaptic Vesicle Endocytosis Cellular Response To Nerve Growth Factor Stimulus	Translation TRNA Aminoacylation For Protein Translation Threonyl-tRNA Aminoacylation TRNA Aminoacylation
Pathways		Regulation of actin dynamics for phagocytic cup formation Regulation of actin dynamics for phagocytic cup formation EPHB-mediated forward signaling RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate WASPs and WAVEs Clathrin-mediated endocytosis FCGR3A-mediated phagocytosis FCGR3A-mediated phagocytosis
Drugs		N-[2-(2-methyl-1H-indol-3-yl)ethyl]thiophene-2-carboxamide (2S)-2-(3-bromophenyl)-3-(5-chloro-2-hydroxyphenyl)-1,3-thiazolidin-4-one
Diseases
GWAS		Automobile speeding propensity ( 30643258) Bipolar disorder ( 31043756) Femoral neck bone mineral density ( 30172743)
Interacting Genes		31 interacting genes: ACTR3 ARAP1 ARPC4 BAG6 CCR10 CDKN2B CEBPA CETP DUSP29 EFTUD2 FAM9A GOLGA2 HOXA3 LATS1 LGALS4 LTA4H MAPK6 NRIP1 OTUD5 POU2F1 PRMT1 RBBP8NL RETREG3 RPS4X SYBU TARS3 THNSL2 WAS WASF2 WASL ZNF576	7 interacting genes: ARPC3 ATF4 DSCAM ECSIT LGALS14 RNF10 TARS2
Entrez ID		10094	123283
HPRD ID		09175	15469
Ensembl ID		ENSG00000111229	ENSG00000185418
Uniprot IDs		O15145	A2RTX5
PDB IDs		6UHC 6YW6 6YW7 8P94
Enriched GO Terms of Interacting Partners?		Regulation Of Cell Projection Assembly Negative Regulation Of Actin Filament Bundle Assembly Actin Filament Polymerization Regulation Of Lamellipodium Assembly Negative Regulation Of Stress Fiber Assembly Positive Regulation Of Plasma Membrane Bounded Cell Projection Assembly Regulation Of Actin Filament Organization Actin Filament Organization Regulation Of Lamellipodium Organization Arp2/3 Protein Complex Actin Polymerization Or Depolymerization Actin Cytoskeleton Actin Filament-based Movement HMG Box Domain Binding Asymmetric Cell Division Protein Polymerization Regulation Of Actin Cytoskeleton Organization Nucleus Arp2/3 Complex-mediated Actin Nucleation Positive Regulation Of Cell Projection Organization Actin Binding Regulation Of Actin Filament-based Process Regulation Of Stress Fiber Assembly Regulation Of Supramolecular Fiber Organization Site Of Double-strand Break
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