ARPC3 and CETP

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
HPRD (two hybrid)

		ARPC3	CETP
Gene Name		actin related protein 2/3 complex, subunit 3, 21kDa	cholesteryl ester transfer protein, plasma
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol Arp2/3 Protein Complex Focal Adhesion Actin Cytoskeleton Membrane Lamellipodium Extracellular Vesicular Exosome	Extracellular Region Extracellular Space Vesicle High-density Lipoprotein Particle Extracellular Vesicular Exosome
	Molecular Function	Structural Constituent Of Cytoskeleton Protein Binding Actin Filament Binding	Lipid Transporter Activity Phospholipid Transporter Activity Lipid Binding Cholesterol Binding Cholesterol Transporter Activity Triglyceride Binding Phosphatidylcholine Binding
	Biological Process	Movement Of Cell Or Subcellular Component Axon Guidance Arp2/3 Complex-mediated Actin Nucleation Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Innate Immune Response Ephrin Receptor Signaling Pathway	Triglyceride Metabolic Process Lipid Transport Receptor-mediated Endocytosis Cholesterol Metabolic Process Negative Regulation Of Macrophage Derived Foam Cell Differentiation Regulation Of Cholesterol Efflux Phospholipid Transport Cholesterol Transport Triglyceride Transport Very-low-density Lipoprotein Particle Remodeling Low-density Lipoprotein Particle Remodeling High-density Lipoprotein Particle Remodeling Lipoprotein Metabolic Process Cholesterol Homeostasis Reverse Cholesterol Transport Small Molecule Metabolic Process Phosphatidylcholine Metabolic Process Transmembrane Transport Lipid Homeostasis Phospholipid Homeostasis Triglyceride Homeostasis
Pathways		EPHB-mediated forward signaling Axon guidance EPH-Ephrin signaling Fcgamma receptor (FCGR) dependent phagocytosis Regulation of actin dynamics for phagocytic cup formation Innate Immune System	Lipoprotein metabolism HDL-mediated lipid transport LDL-mediated lipid transport Metabolism of lipids and lipoproteins Lipid digestion, mobilization, and transport Orphan transporters
Drugs
Diseases
GWAS			Age-related macular degeneration ( 20385819 23455636 21665990) Biochemical measures ( 19260141) Cardiovascular disease risk factors ( 21943158 20838585) Cholesterol ( 20066028) Cholesterol, total ( 20686565) Coronary heart disease ( 21347282) HDL cholesterol ( 23726366 20031538 19359809 20031564 21909109 18193043 18193044 20864672 19060906 23505323 19060910 19060911 20686565) HDL Cholesterol - Triglycerides (HDLC-TG) ( 21386085) Hematological and biochemical traits ( 20139978) LDL cholesterol ( 20686565) Lipid metabolism phenotypes ( 22286219 19936222) Lipoprotein-associated phospholipase A2 activity and mass ( 22003152 23118302) Metabolic syndrome ( 22399527 21386085 20694148) Metabolic syndrome (bivariate traits) ( 21386085) Metabolite levels ( 22916037) Triglycerides ( 17463246 20686565) Waist circumference and related phenotypes ( 18454146)
Protein-Protein Interactions		20 interactors: ACTR3 ARAP1 ARPC4 BAG6 CDKN2B CETP EFTUD2 GOLGA2 HOXA3 LGALS4 LTA4H MAPK6 NRIP1 OTUD5 PRMT1 RPS4X THNSL2 WAS WASF2 WASL	5 interactors: APOA1 ARPC3 EWSR1 LPL PRKACG
Entrez ID		10094	1071
HPRD ID		09175	00325
Ensembl ID		ENSG00000111229	ENSG00000087237
Uniprot IDs		O15145	P11597
PDB IDs			2OBD 4EWS 4F2A
Enriched GO Terms of Interacting Partners?		Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Regulation Of Actin Cytoskeleton Organization Regulation Of Actin Filament-based Process Phagocytosis Regulation Of Cytoskeleton Organization Fc Receptor Signaling Pathway Regulation Of Cell Projection Assembly Immune Response-activating Cell Surface Receptor Signaling Pathway Positive Regulation Of Filopodium Assembly Actin Filament Organization Positive Regulation Of Cellular Component Biogenesis Actin Cytoskeleton Organization Regulation Of Filopodium Assembly Actin Filament-based Process Immune Response-regulating Cell Surface Receptor Signaling Pathway Endocytosis Positive Regulation Of Arp2/3 Complex-mediated Actin Nucleation Positive Regulation Of Actin Nucleation Actin Filament-based Movement Positive Regulation Of Cytoskeleton Organization Immune System Process Immune Response-regulating Signaling Pathway Innate Immune Response Negative Regulation Of Stress Fiber Assembly Actin Polymerization Or Depolymerization Negative Regulation Of Actin Filament Bundle Assembly Positive Regulation Of Lamellipodium Assembly Defense Response Cell Cycle Regulation Of Organelle Organization Ephrin Receptor Signaling Pathway Positive Regulation Of Cell Projection Organization Positive Regulation Of Lamellipodium Organization Regulation Of Arp2/3 Complex-mediated Actin Nucleation Positive Regulation Of Immune Response Megakaryocyte Differentiation Regulation Of Actin Nucleation Regulation Of Lamellipodium Assembly Cytoskeleton Organization Positive Regulation Of Organelle Organization Immune Response Arp2/3 Complex-mediated Actin Nucleation Regulation Of Immune System Process Regulation Of Immune Response Actin Filament Polymerization Regulation Of Cell Projection Organization Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Immune System Process	Triglyceride Catabolic Process Acylglycerol Catabolic Process Plasma Lipoprotein Particle Remodeling Triglyceride Homeostasis Acylglycerol Homeostasis Glycerolipid Metabolic Process Regulation Of Plasma Lipoprotein Particle Levels Phototransduction, Visible Light Retinoid Metabolic Process Diterpenoid Metabolic Process Positive Regulation Of Lipase Activity Detection Of Visible Light Triglyceride Metabolic Process Phototransduction Neutral Lipid Metabolic Process Detection Of Light Stimulus Negative Regulation Of Cell Adhesion Molecule Production Lipid Homeostasis Isoprenoid Metabolic Process Cellular Lipid Catabolic Process Negative Regulation Of Interleukin-1 Beta Secretion Chemical Homeostasis Lipoprotein Metabolic Process Detection Of Abiotic Stimulus Negative Regulation Of Very-low-density Lipoprotein Particle Remodeling Cholesterol Import Chylomicron Remodeling Cellular Lipid Metabolic Process Positive Regulation Of Cytoskeleton Organization Negative Regulation Of Interleukin-1 Secretion Lipid Catabolic Process High-density Lipoprotein Particle Clearance Positive Regulation Of Sequestering Of Triglyceride Protein Oxidation Lipid Metabolic Process Negative Regulation Of Heterotypic Cell-cell Adhesion Negative Regulation Of Cytokine Secretion Involved In Immune Response High-density Lipoprotein Particle Assembly Positive Regulation Of Cellular Component Biogenesis Very-low-density Lipoprotein Particle Remodeling Homeostatic Process Positive Regulation Of Triglyceride Catabolic Process Positive Regulation Of Cholesterol Esterification Regulation Of Intestinal Cholesterol Absorption Phospholipid Homeostasis Peptidyl-methionine Modification Response To Light Stimulus Response To Stress Regulation Of Actin Cytoskeleton Organization Regulation Of Cholesterol Esterification
Tagcloud ?		aberrant coincident collective combinatorial computational concurrently consider cytoskeleton dysregulated enriched extensive focal metastasis metastatic microrna micrornas mounting nodes notable numerous organization perturbed rankl repression reveals summary tgfb1 transcripts upstream	allele allelic b1 b1b1 b2b2 carriers causal causally chd cholesteryl circulating duplicate embase ester genotype genotypic instrument marginally mendelian mug probabilities publication pubmed qualified randomization rs708272 searched unresolved weighted
Tagcloud (Difference) ?		aberrant coincident collective combinatorial computational concurrently consider cytoskeleton dysregulated enriched extensive focal metastasis metastatic microrna micrornas mounting nodes notable numerous organization perturbed rankl repression reveals summary tgfb1 transcripts upstream	allele allelic b1 b1b1 b2b2 carriers causal causally chd cholesteryl circulating duplicate embase ester genotype genotypic instrument marginally mendelian mug probabilities publication pubmed qualified randomization rs708272 searched unresolved weighted
Tagcloud (Intersection) ?