ARPC3 and HOXA3

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid, two hybrid)

		ARPC3	HOXA3
Description		actin related protein 2/3 complex subunit 3	homeobox A3
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Cytoskeleton Arp2/3 Protein Complex Focal Adhesion Actin Cytoskeleton Membrane Lamellipodium Cell Leading Edge Filamentous Actin Site Of Double-strand Break Cell Projection Growth Cone Leading Edge Extracellular Exosome	Chromatin Nucleus Nucleoplasm
	Molecular Function	Actin Binding Structural Constituent Of Cytoskeleton Protein Binding Actin Filament Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding HMG Box Domain Binding
	Biological Process	Regulation Of Actin Filament Polymerization Arp2/3 Complex-mediated Actin Nucleation Actin Polymerization-dependent Cell Motility Regulation Of Synaptic Vesicle Endocytosis Cellular Response To Nerve Growth Factor Stimulus	Angiogenesis Blood Vessel Remodeling Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Cell Population Proliferation Animal Organ Morphogenesis Anterior/posterior Pattern Specification Specification Of Animal Organ Position Gene Expression Glossopharyngeal Nerve Morphogenesis Thyroid Gland Development Thymus Development Animal Organ Formation Embryonic Skeletal System Morphogenesis Embryonic Skeletal System Development Cartilage Development Parathyroid Gland Development Stem Cell Proliferation Positive Regulation Of Stem Cell Proliferation
Pathways		Regulation of actin dynamics for phagocytic cup formation Regulation of actin dynamics for phagocytic cup formation EPHB-mediated forward signaling RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate WASPs and WAVEs Clathrin-mediated endocytosis FCGR3A-mediated phagocytosis FCGR3A-mediated phagocytosis	Activation of anterior HOX genes in hindbrain development during early embryogenesis
Drugs		N-[2-(2-methyl-1H-indol-3-yl)ethyl]thiophene-2-carboxamide (2S)-2-(3-bromophenyl)-3-(5-chloro-2-hydroxyphenyl)-1,3-thiazolidin-4-one
Diseases
GWAS		Automobile speeding propensity ( 30643258) Bipolar disorder ( 31043756) Femoral neck bone mineral density ( 30172743)	A body shape index ( 34021172) Chronic venous disease ( 28374850) Diastolic blood pressure ( 27618448) Hypertension ( 27618448 30487518) Lymphocyte count ( 32888494) Mean arterial pressure ( 27618448) Monocyte count ( 27863252 32888494) Pulse pressure ( 30487518) Systolic blood pressure ( 30487518 28135244 27618448) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172) White blood cell count ( 32888494)
Interacting Genes		31 interacting genes: ACTR3 ARAP1 ARPC4 BAG6 CCR10 CDKN2B CEBPA CETP DUSP29 EFTUD2 FAM9A GOLGA2 HOXA3 LATS1 LGALS4 LTA4H MAPK6 NRIP1 OTUD5 POU2F1 PRMT1 RBBP8NL RETREG3 RPS4X SYBU TARS3 THNSL2 WAS WASF2 WASL ZNF576	10 interacting genes: ALX4 ARPC3 POT1 PWP1 RCHY1 SEC23B SOX10 TERF1 TINF2 ZDHHC17
Entrez ID		10094	3200
HPRD ID		09175	00842
Ensembl ID		ENSG00000111229	ENSG00000105997
Uniprot IDs		O15145	A4D182 B3KPN8 O43365
PDB IDs		6UHC 6YW6 6YW7 8P94
Enriched GO Terms of Interacting Partners?		Regulation Of Cell Projection Assembly Negative Regulation Of Actin Filament Bundle Assembly Actin Filament Polymerization Regulation Of Lamellipodium Assembly Negative Regulation Of Stress Fiber Assembly Positive Regulation Of Plasma Membrane Bounded Cell Projection Assembly Regulation Of Actin Filament Organization Actin Filament Organization Regulation Of Lamellipodium Organization Arp2/3 Protein Complex Actin Polymerization Or Depolymerization Actin Cytoskeleton Actin Filament-based Movement HMG Box Domain Binding Asymmetric Cell Division Protein Polymerization Regulation Of Actin Cytoskeleton Organization Nucleus Arp2/3 Complex-mediated Actin Nucleation Positive Regulation Of Cell Projection Organization Actin Binding Regulation Of Actin Filament-based Process Regulation Of Stress Fiber Assembly Regulation Of Supramolecular Fiber Organization Site Of Double-strand Break	Shelterin Complex Nuclear Telomere Cap Complex Telomere Capping Negative Regulation Of Telomere Maintenance Via Telomerase Telomeric DNA Binding Negative Regulation Of DNA Biosynthetic Process Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Negative Regulation Of Telomere Maintenance Regulation Of Telomere Maintenance Via Telomerase Telomere Assembly Regulation Of Telomere Maintenance Via Telomere Lengthening Positive Regulation Of Telomere Maintenance Negative Regulation Of Chromosome Organization Telomeric D-loop Disassembly G-rich Strand Telomeric DNA Binding Regulation Of DNA Biosynthetic Process DNA Biosynthetic Process Telomeric Loop Disassembly Telomere Maintenance Positive Regulation Of Chromosome Organization Regulation Of Telomere Maintenance Telomere Organization Negative Regulation Of DNA Metabolic Process Nucleobase-containing Compound Biosynthetic Process Telomere Maintenance Via Telomerase RNA-templated DNA Biosynthetic Process Chromosome, Telomeric Region Telomere Maintenance Via Telomere Lengthening Regulation Of Chromosome Organization Positive Regulation Of Nucleobase-containing Compound Metabolic Process Nucleic Acid Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of Establishment Of Protein Localization To Telomere Negative Regulation Of Establishment Of Protein-containing Complex Localization To Telomere DNA Metabolic Process Negative Regulation Of Establishment Of RNA Localization To Telomere Positive Regulation Of DNA Metabolic Process Chromosome Positive Regulation Of Shelterin Complex Assembly Growth Cone Leading Edge Histone H4K20me3 Reader Activity Perforant Pathway To Dendrate Granule Cell Synapse Positive Regulation Of DNA Strand Elongation Positive Regulation Of Telomeric D-loop Disassembly G-rich Single-stranded DNA Binding Macromolecule Biosynthetic Process Chromosome Organization Positive Regulation Of Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Telomeric D-loop Disassembly
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