ARPC3 and WASF2

Number of citations of the paper that reports this interaction (PMID 11146629)
91

Data Source:
HPRD (in vitro)

		ARPC3	WASF2
Gene Name		actin related protein 2/3 complex, subunit 3, 21kDa	WAS protein family, member 2
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol Arp2/3 Protein Complex Focal Adhesion Actin Cytoskeleton Membrane Lamellipodium Extracellular Vesicular Exosome	Ruffle Intracellular Early Endosome Cytosol Cell-cell Junction Actin Cytoskeleton Lamellipodium SCAR Complex Extracellular Vesicular Exosome
	Molecular Function	Structural Constituent Of Cytoskeleton Protein Binding Actin Filament Binding	Actin Binding Protein Binding Protein Complex Binding
	Biological Process	Movement Of Cell Or Subcellular Component Axon Guidance Arp2/3 Complex-mediated Actin Nucleation Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Innate Immune Response Ephrin Receptor Signaling Pathway	Angiogenesis Ameboidal-type Cell Migration Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Lamellipodium Assembly Rac Protein Signal Transduction Lamellipodium Assembly Actin Cytoskeleton Organization Actin Filament-based Movement Megakaryocyte Development Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Innate Immune Response Vascular Endothelial Growth Factor Receptor Signaling Pathway Negative Regulation Of Stress Fiber Assembly Lamellipodium Morphogenesis
Pathways		EPHB-mediated forward signaling Axon guidance EPH-Ephrin signaling Fcgamma receptor (FCGR) dependent phagocytosis Regulation of actin dynamics for phagocytic cup formation Innate Immune System	Signaling by VEGF Fcgamma receptor (FCGR) dependent phagocytosis VEGFA-VEGFR2 Pathway Regulation of actin dynamics for phagocytic cup formation Innate Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		20 interactors: ACTR3 ARAP1 ARPC4 BAG6 CDKN2B CETP EFTUD2 GOLGA2 HOXA3 LGALS4 LTA4H MAPK6 NRIP1 OTUD5 PRMT1 RPS4X THNSL2 WAS WASF2 WASL	23 interactors: ABI1 ABI2 ABI3 ABL1 ACTB ACTR2 ACTR3 APBB1 ARPC3 BAIAP2 BTK CDC42 CYFIP2 DOCK1 FYN GAS7 GRB2 ITSN2 NCKAP1 PACSIN1 PRPF40A PSTPIP1 TCERG1
Entrez ID		10094	10163
HPRD ID		09175	05796
Ensembl ID		ENSG00000111229	ENSG00000158195
Uniprot IDs		O15145	Q9Y6W5
PDB IDs			2A40
Enriched GO Terms of Interacting Partners?		Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Regulation Of Actin Cytoskeleton Organization Regulation Of Actin Filament-based Process Phagocytosis Regulation Of Cytoskeleton Organization Fc Receptor Signaling Pathway Regulation Of Cell Projection Assembly Immune Response-activating Cell Surface Receptor Signaling Pathway Positive Regulation Of Filopodium Assembly Actin Filament Organization Positive Regulation Of Cellular Component Biogenesis Actin Cytoskeleton Organization Regulation Of Filopodium Assembly Actin Filament-based Process Immune Response-regulating Cell Surface Receptor Signaling Pathway Endocytosis Positive Regulation Of Arp2/3 Complex-mediated Actin Nucleation Positive Regulation Of Actin Nucleation Actin Filament-based Movement Positive Regulation Of Cytoskeleton Organization Immune System Process Immune Response-regulating Signaling Pathway Innate Immune Response Negative Regulation Of Stress Fiber Assembly Actin Polymerization Or Depolymerization Negative Regulation Of Actin Filament Bundle Assembly Positive Regulation Of Lamellipodium Assembly Defense Response Cell Cycle Regulation Of Organelle Organization Ephrin Receptor Signaling Pathway Positive Regulation Of Cell Projection Organization Positive Regulation Of Lamellipodium Organization Regulation Of Arp2/3 Complex-mediated Actin Nucleation Positive Regulation Of Immune Response Megakaryocyte Differentiation Regulation Of Actin Nucleation Regulation Of Lamellipodium Assembly Cytoskeleton Organization Positive Regulation Of Organelle Organization Immune Response Arp2/3 Complex-mediated Actin Nucleation Regulation Of Immune System Process Regulation Of Immune Response Actin Filament Polymerization Regulation Of Cell Projection Organization Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Immune System Process	Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Fc Receptor Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Endocytosis Phagocytosis Immune Response-regulating Cell Surface Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Innate Immune Response Positive Regulation Of Immune Response Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cell Projection Organization Vesicle-mediated Transport Neuron Projection Development Cell Projection Morphogenesis Neuron Projection Morphogenesis Cell Part Morphogenesis Regulation Of Immune Response Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Immune System Process Neuron Development Immune Response Vascular Endothelial Growth Factor Receptor Signaling Pathway Actin Filament Organization Cell Morphogenesis Defense Response Neuron Differentiation Cell Development Movement Of Cell Or Subcellular Component Axonogenesis Regulation Of Immune System Process Axon Guidance Axon Development Cell Morphogenesis Involved In Neuron Differentiation Actin Cytoskeleton Organization Actin Filament-based Process Generation Of Neurons Locomotion Cell Morphogenesis Involved In Differentiation Neurogenesis Immune System Process Cytoskeleton Organization Chemotaxis Nervous System Development Regulation Of Cellular Component Organization Anatomical Structure Morphogenesis Regulation Of Cytoskeleton Organization Ephrin Receptor Signaling Pathway Regulation Of Actin Cytoskeleton Organization
Tagcloud ?		aberrant coincident collective combinatorial computational concurrently consider cytoskeleton dysregulated enriched extensive focal metastasis metastatic microrna micrornas mounting nodes notable numerous organization perturbed rankl repression reveals summary tgfb1 transcripts upstream
Tagcloud (Difference) ?		aberrant coincident collective combinatorial computational concurrently consider cytoskeleton dysregulated enriched extensive focal metastasis metastatic microrna micrornas mounting nodes notable numerous organization perturbed rankl repression reveals summary tgfb1 transcripts upstream
Tagcloud (Intersection) ?