ARPC3 and EFTUD2

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		ARPC3	EFTUD2
Gene Name		actin related protein 2/3 complex, subunit 3, 21kDa	elongation factor Tu GTP binding domain containing 2
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol Arp2/3 Protein Complex Focal Adhesion Actin Cytoskeleton Membrane Lamellipodium Extracellular Vesicular Exosome	Nucleoplasm Spliceosomal Complex Cytoplasm Cajal Body Membrane Nuclear Speck Catalytic Step 2 Spliceosome
	Molecular Function	Structural Constituent Of Cytoskeleton Protein Binding Actin Filament Binding	GTPase Activity Protein Binding GTP Binding Poly(A) RNA Binding
	Biological Process	Movement Of Cell Or Subcellular Component Axon Guidance Arp2/3 Complex-mediated Actin Nucleation Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Innate Immune Response Ephrin Receptor Signaling Pathway	MRNA Splicing, Via Spliceosome MRNA Processing RNA Splicing Gene Expression
Pathways		EPHB-mediated forward signaling Axon guidance EPH-Ephrin signaling Fcgamma receptor (FCGR) dependent phagocytosis Regulation of actin dynamics for phagocytic cup formation Innate Immune System	Processing of Capped Intron-Containing Pre-mRNA mRNA Splicing mRNA Splicing - Minor Pathway mRNA Splicing - Major Pathway
Drugs
Diseases
GWAS
Protein-Protein Interactions		20 interactors: ACTR3 ARAP1 ARPC4 BAG6 CDKN2B CETP EFTUD2 GOLGA2 HOXA3 LGALS4 LTA4H MAPK6 NRIP1 OTUD5 PRMT1 RPS4X THNSL2 WAS WASF2 WASL	16 interactors: ARPC3 CYFIP1 GOLM1 GSK3B HINFP HSPB1 LSM8 PIN1 PRPF6 PRPF8 SF1 SF3B3 SF3B4 SNRNP40 SREK1 WBP4
Entrez ID		10094	9343
HPRD ID		09175	04869
Ensembl ID		ENSG00000111229	ENSG00000108883
Uniprot IDs		O15145	B3KX19 B4DMC0 K7EJ81 Q15029
PDB IDs
Enriched GO Terms of Interacting Partners?		Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Regulation Of Actin Cytoskeleton Organization Regulation Of Actin Filament-based Process Phagocytosis Regulation Of Cytoskeleton Organization Fc Receptor Signaling Pathway Regulation Of Cell Projection Assembly Immune Response-activating Cell Surface Receptor Signaling Pathway Positive Regulation Of Filopodium Assembly Actin Filament Organization Positive Regulation Of Cellular Component Biogenesis Actin Cytoskeleton Organization Regulation Of Filopodium Assembly Actin Filament-based Process Immune Response-regulating Cell Surface Receptor Signaling Pathway Endocytosis Positive Regulation Of Arp2/3 Complex-mediated Actin Nucleation Positive Regulation Of Actin Nucleation Actin Filament-based Movement Positive Regulation Of Cytoskeleton Organization Immune System Process Immune Response-regulating Signaling Pathway Innate Immune Response Negative Regulation Of Stress Fiber Assembly Actin Polymerization Or Depolymerization Negative Regulation Of Actin Filament Bundle Assembly Positive Regulation Of Lamellipodium Assembly Defense Response Cell Cycle Regulation Of Organelle Organization Ephrin Receptor Signaling Pathway Positive Regulation Of Cell Projection Organization Positive Regulation Of Lamellipodium Organization Regulation Of Arp2/3 Complex-mediated Actin Nucleation Positive Regulation Of Immune Response Megakaryocyte Differentiation Regulation Of Actin Nucleation Regulation Of Lamellipodium Assembly Cytoskeleton Organization Positive Regulation Of Organelle Organization Immune Response Arp2/3 Complex-mediated Actin Nucleation Regulation Of Immune System Process Regulation Of Immune Response Actin Filament Polymerization Regulation Of Cell Projection Organization Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Immune System Process	RNA Splicing MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions MRNA Processing MRNA Metabolic Process RNA Processing Gene Expression RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Spliceosomal Tri-snRNP Complex Assembly Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Ribonucleoprotein Complex Assembly Spliceosomal SnRNP Assembly Positive Regulation Of Cellular Metabolic Process Spliceosomal Complex Assembly Ribonucleoprotein Complex Biogenesis Negative Regulation Of Type B Pancreatic Cell Development Superior Temporal Gyrus Development Re-entry Into Mitotic Cell Cycle Negative Regulation Of Neuron Maturation Negative Regulation Of Phosphorylation Positive Regulation Of Organelle Organization Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Intracellular Signal Transduction Positive Regulation Of Gene Expression Regulation Of Organelle Organization Hypermethylation Of CpG Island Primary Sex Determination Positive Regulation Of Endothelial Cell Chemotaxis By VEGF-activated Vascular Endothelial Growth Factor Receptor Signaling Pathway Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Apoptotic Process Positive Regulation Of Cellular Biosynthetic Process MRNA 3'-splice Site Recognition Positive Regulation Of Cell Migration By Vascular Endothelial Growth Factor Signaling Pathway Cellular Response To Interleukin-3 Negative Regulation Of Protein Serine/threonine Kinase Activity Negative Regulation Of Female Gonad Development Positive Regulation Of Metabolic Process Negative Regulation Of Glycogen (starch) Synthase Activity Regulation Of Neuron Maturation Axonogenesis Negative Regulation Of MAPK Cascade Positive Regulation Of Arp2/3 Complex-mediated Actin Nucleation Protein Localization To Microtubule Positive Regulation Of Actin Nucleation Negative Regulation Of Dendrite Morphogenesis Positive Regulation Of Endothelial Cell Chemotaxis Positive Regulation Of Protein Complex Assembly
Tagcloud ?		aberrant coincident collective combinatorial computational concurrently consider cytoskeleton dysregulated enriched extensive focal metastasis metastatic microrna micrornas mounting nodes notable numerous organization perturbed rankl repression reveals summary tgfb1 transcripts upstream	3k36me3 antagonizing arranged bromo bs69 called chromatin connects decorated depends h3k36me3 identifies intron ir modalities phd pwwp reader recognizes remarkably retention reveals snrnp spliceosome splicing tandemly trimethylation u5 zmynd11
Tagcloud (Difference) ?		aberrant coincident collective combinatorial computational concurrently consider cytoskeleton dysregulated enriched extensive focal metastasis metastatic microrna micrornas mounting nodes notable numerous organization perturbed rankl repression summary tgfb1 transcripts upstream	3k36me3 antagonizing arranged bromo bs69 called chromatin connects decorated depends h3k36me3 identifies intron ir modalities phd pwwp reader recognizes remarkably retention snrnp spliceosome splicing tandemly trimethylation u5 zmynd11
Tagcloud (Intersection) ?		reveals