FAM210B and VKORC1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		FAM210B	VKORC1
Description		family with sequence similarity 210 member B	vitamin K epoxide reductase complex subunit 1
Image		No pdb structure
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Outer Membrane Membrane	Endoplasmic Reticulum Endoplasmic Reticulum Lumen Endoplasmic Reticulum Membrane Membrane
	Molecular Function	Protein Binding	Protein Binding Oxidoreductase Activity Oxidoreductase Activity, Acting On CH Or CH2 Groups, Disulfide As Acceptor Vitamin-K-epoxide Reductase (warfarin-sensitive) Activity Vitamin-K-epoxide Reductase (warfarin-insensitive) Activity Quinone Binding
	Biological Process	Inflammatory Response Cell Differentiation Erythrocyte Differentiation Erythrocyte Maturation Skin Development Positive Regulation Of Erythrocyte Differentiation Spleen Development Cellular Response To Estradiol Stimulus Reactive Oxygen Species Metabolic Process	Xenobiotic Metabolic Process Blood Coagulation Peptidyl-glutamic Acid Carboxylation Vitamin K Metabolic Process Positive Regulation Of Coagulation Bone Development
Pathways			Metabolism of vitamin K
Drugs			Menadione Dicoumarol Phenindione Warfarin Phenprocoumon Acenocoumarol
Diseases			Combined deficiency of vitamin K-dependent clotting factors (VKCFD)
GWAS			Bipolar disorder ( 31043756) Bipolar I disorder ( 31043756) Body fat distribution (arm fat ratio) ( 30664634) Warfarin maintenance dose ( 18535201 19300499 20833655 26265036) Warfarin maintenance dose (adjusted for clinical factors) ( 28686080)
Interacting Genes		66 interacting genes: ADGRE2 APOL2 ATP6V0B ATP6V0C BCL2L13 BET1 C1GALT1 C5orf46 CCDC167 CD300C CLDND2 CNIH3 CYB5B CYB5R3 CYP4F2 EMP3 FIS1 FXYD6-FXYD2 GIMAP5 HEXB HMOX1 HMOX2 IER3IP1 IFITM3 INSIG2 LNPEP LPAR3 MFF MS4A13 NINJ2 NKG7 ORMDL2 OTOP3 PLP2 PLPP6 RPRM RTP2 SERP1 SERP2 SLC16A13 SLC30A8 SLC35B4 SLC35G1 SMCO4 SMIM1 STATH STX6 STX7 SYNJ2BP TF TFRC TIMM23 TIMMDC1 TMEM107 TMEM11 TMEM140 TMEM187 TMEM19 TMIE UBE2J1 VAMP1 VAMP3 VAMP4 VKORC1 YIF1A ZDHHC21	93 interacting genes: AHSG APLP2 APOA1 APOA2 APOC1 APOC3 APOC4 ARL6IP5 ASGR1 ASGR2 ATP5MC3 ATP6AP2 BCAP31 C1S CCDC12 CCDC167 CD63 CD81 CD9 CLDN10 CNN3 COMT CPLX4 CREB3 CREB3L1 CXADR DPM2 ECHDC1 FAM209A FAM210B FGG FGL1 FIS1 FTL GJB1 GORAB GPR152 HAMP HDAC6 HOMER2 HP HPR HSD17B7 IFITM3 JAGN1 KCNK17 LIG4 LMNA MANBAL MSMO1 MSRB1 MT1X MUC1 PCDH1 PCMT1 PDIA6 PIGH PLP2 PPA2 PPIB PROCR REEP5 RMDN1 RMDN3 RMND5A SAA1 SAT1 SERPINA1 SLC15A3 SLC22A2 SLC25A1 SLC31A2 SLC7A14 SNORA12 SPTSSA STAT6 SURF4 TF TMBIM4 TMEM120A TMEM134 TMEM176A TMEM230 TMEM242 TMEM256 TMEM35B TMEM45B TMT1B TRAM1 TREX1 VAPB YIF1A ZCCHC24
Entrez ID		116151	79001
HPRD ID		12737	10540
Ensembl ID		ENSG00000124098	ENSG00000167397
Uniprot IDs		Q96KR6	A0A0S2Z5X7 A0A0S2Z6I4 Q9BQB6
PDB IDs			6WV3 6WV4 6WV5 6WV6 6WV7 6WVH
Enriched GO Terms of Interacting Partners?		Membrane Endoplasmic Reticulum Membrane SNARE Complex SNAP Receptor Activity Golgi Membrane Establishment Of Protein Localization Endoplasmic Reticulum Mitochondrial Outer Membrane Heme Oxidation Heme Oxygenase (decyclizing) Activity SNARE Complex Assembly Organelle Fusion Protein Binding Intracellular Chemical Homeostasis Nitric-oxide Synthase Complex Vesicle Fusion Synaptic Vesicle To Endosome Fusion Transport Vesicle Organelle Membrane Fusion Monoatomic Cation Homeostasis Monoatomic Ion Homeostasis Chemical Homeostasis Proton-transporting Two-sector ATPase Complex, Proton-transporting Domain Intracellular Monoatomic Cation Homeostasis Nitrite Reductase (NO-forming) Activity Multicellular Organismal-level Iron Ion Homeostasis Clathrin-coated Endocytic Vesicle Membrane Protein Targeting Multicellular Organismal-level Chemical Homeostasis Cellular Homeostasis Intracellular Monoatomic Ion Homeostasis Recycling Endosome Protein Targeting To Mitochondrion Nitric Oxide Metabolic Process Plasma Membrane Reactive Nitrogen Species Metabolic Process Membrane Fusion Cholesterol Biosynthetic Process HFE-transferrin Receptor Complex Negative Regulation Of Fatty Acid Transport Golgi Lumen Acidification Vacuolar Proton-transporting V-type ATPase, V0 Domain Proton-transporting V-type ATPase, V0 Domain Sterol Biosynthetic Process Bleb Assembly Heme Catabolic Process Response To Type II Interferon Golgi Vesicle Transport Azurophil Granule Protein Transport	Endoplasmic Reticulum Membrane Spherical High-density Lipoprotein Particle Very-low-density Lipoprotein Particle High-density Lipoprotein Particle High-density Lipoprotein Particle Receptor Binding Blood Microparticle Endoplasmic Reticulum Chylomicron Cholesterol Efflux Phospholipid Efflux Membrane Cholesterol Transport Phosphatidylcholine-sterol O-acyltransferase Activator Activity Negative Regulation Of Very-low-density Lipoprotein Particle Remodeling High-density Lipoprotein Particle Remodeling Sterol Transport Lipase Inhibitor Activity Plasma Lipoprotein Particle Assembly Protein-lipid Complex Assembly Plasma Lipoprotein Particle Clearance Extracellular Exosome Lipoprotein Metabolic Process Organic Hydroxy Compound Transport Asialoglycoprotein Receptor Activity Regulation Of Transport Endoplasmic Reticulum Lumen Regulation Of Intestinal Absorption Plasma Lipoprotein Particle Remodeling Response To Endoplasmic Reticulum Stress Cellular Response To Lipoprotein Particle Stimulus Protein-containing Complex Remodeling Lipid Transport Negative Regulation Of Lipid Transport Zymogen Activation Acute-phase Response Chemical Homeostasis Triglyceride Homeostasis Acylglycerol Homeostasis Peptidyl-methionine Modification Negative Regulation Of Cholesterol Import Myoblast Fusion Involved In Skeletal Muscle Regeneration Iron Ion Export Across Plasma Membrane Reverse Cholesterol Transport Regulation Of Lipid Transport Defense Response Endocytic Vesicle Lumen Cholesterol Binding Apolipoprotein Receptor Binding Negative Regulation Of Very-low-density Lipoprotein Particle Clearance Negative Regulation Of Cholesterol Transport
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