FAM210B and HEXB

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		FAM210B	HEXB
Description		family with sequence similarity 210 member B	hexosaminidase subunit beta
Image		No pdb structure
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Outer Membrane Membrane	Acrosomal Vesicle Extracellular Region Extracellular Space Lysosome Membrane Cytoplasmic Vesicle Azurophil Granule Lumen Azurophil Granule Lysosomal Lumen Cortical Granule Extracellular Exosome Beta-N-acetylhexosaminidase Complex
	Molecular Function	Protein Binding	Hydrolase Activity, Hydrolyzing O-glycosyl Compounds Beta-N-acetylhexosaminidase Activity Protein Binding Acetylglucosaminyltransferase Activity Hexosaminidase Activity Beta-N-acetylglucosaminidase Activity Hydrolase Activity Hydrolase Activity, Acting On Glycosyl Bonds Carbohydrate Binding Identical Protein Binding Protein-containing Complex Binding
	Biological Process	Inflammatory Response Cell Differentiation Erythrocyte Differentiation Erythrocyte Maturation Skin Development Positive Regulation Of Erythrocyte Differentiation Spleen Development Cellular Response To Estradiol Stimulus Reactive Oxygen Species Metabolic Process	Skeletal System Development Carbohydrate Metabolic Process N-acetylglucosamine Metabolic Process N-glycan Processing Lipid Metabolic Process Glycosphingolipid Metabolic Process Ganglioside Catabolic Process Intracellular Calcium Ion Homeostasis Lysosome Organization Single Fertilization Penetration Of Zona Pellucida Sensory Perception Of Sound Locomotory Behavior Male Courtship Behavior Regulation Of Cell Shape Phospholipid Biosynthetic Process Oligosaccharide Catabolic Process Regulation Of Metabolic Process Lipid Storage Sexual Reproduction Glycosaminoglycan Metabolic Process Chondroitin Sulfate Proteoglycan Catabolic Process Dermatan Sulfate Proteoglycan Catabolic Process Hyaluronan Catabolic Process Myelination Astrocyte Cell Migration Positive Regulation Of Transcription By RNA Polymerase II Oogenesis Neuromuscular Process Controlling Balance Neuromuscular Process Neuron Cellular Homeostasis Carbohydrate Derivative Metabolic Process
Pathways			Keratan sulfate degradation CS/DS degradation Hyaluronan degradation Defective HEXB causes GM2G2 (Hyaluronan metabolism) Neutrophil degranulation Glycosphingolipid catabolism
Drugs			Pyrimethamine 2-Acetamido-2-Deoxy-D-Glucono-1,5-Lactone N-Acetyl-glucosamine thiazoline (2R,3R,4S,5R)-2-acetamido-3,4-dihydroxy-5-hydroxymethyl-piperidine
Diseases			GM2 gangliosidoses, including: Tay-Sachs disease (type I); Sandhoff disease (type II); Tay-Sachs disease AB variant
GWAS			Gut microbiota relative abundance (unassigned genus belonging to family Clostridiales) ( 33208821) Metabolite levels ( 23823483) Night sleep phenotypes ( 27126917)
Interacting Genes		66 interacting genes: ADGRE2 APOL2 ATP6V0B ATP6V0C BCL2L13 BET1 C1GALT1 C5orf46 CCDC167 CD300C CLDND2 CNIH3 CYB5B CYB5R3 CYP4F2 EMP3 FIS1 FXYD6-FXYD2 GIMAP5 HEXB HMOX1 HMOX2 IER3IP1 IFITM3 INSIG2 LNPEP LPAR3 MFF MS4A13 NINJ2 NKG7 ORMDL2 OTOP3 PLP2 PLPP6 RPRM RTP2 SERP1 SERP2 SLC16A13 SLC30A8 SLC35B4 SLC35G1 SMCO4 SMIM1 STATH STX6 STX7 SYNJ2BP TF TFRC TIMM23 TIMMDC1 TMEM107 TMEM11 TMEM140 TMEM187 TMEM19 TMIE UBE2J1 VAMP1 VAMP3 VAMP4 VKORC1 YIF1A ZDHHC21	6 interacting genes: AIRE CSNK2B EIF2D FAM210B HOXA1 TMEM14B
Entrez ID		116151	3074
HPRD ID		12737	06043
Ensembl ID		ENSG00000124098	ENSG00000049860
Uniprot IDs		Q96KR6	A0A024RAJ6 P07686 Q5URX0
PDB IDs			1NOU 1NOW 1NP0 1O7A 2GJX 2GK1 3LMY 5BRO
Enriched GO Terms of Interacting Partners?		Membrane Endoplasmic Reticulum Membrane SNARE Complex SNAP Receptor Activity Golgi Membrane Establishment Of Protein Localization Endoplasmic Reticulum Mitochondrial Outer Membrane Heme Oxidation Heme Oxygenase (decyclizing) Activity SNARE Complex Assembly Organelle Fusion Protein Binding Intracellular Chemical Homeostasis Nitric-oxide Synthase Complex Vesicle Fusion Synaptic Vesicle To Endosome Fusion Transport Vesicle Organelle Membrane Fusion Monoatomic Cation Homeostasis Monoatomic Ion Homeostasis Chemical Homeostasis Proton-transporting Two-sector ATPase Complex, Proton-transporting Domain Intracellular Monoatomic Cation Homeostasis Nitrite Reductase (NO-forming) Activity Multicellular Organismal-level Iron Ion Homeostasis Clathrin-coated Endocytic Vesicle Membrane Protein Targeting Multicellular Organismal-level Chemical Homeostasis Cellular Homeostasis Intracellular Monoatomic Ion Homeostasis Recycling Endosome Protein Targeting To Mitochondrion Nitric Oxide Metabolic Process Plasma Membrane Reactive Nitrogen Species Metabolic Process Membrane Fusion Cholesterol Biosynthetic Process HFE-transferrin Receptor Complex Negative Regulation Of Fatty Acid Transport Golgi Lumen Acidification Vacuolar Proton-transporting V-type ATPase, V0 Domain Proton-transporting V-type ATPase, V0 Domain Sterol Biosynthetic Process Bleb Assembly Heme Catabolic Process Response To Type II Interferon Golgi Vesicle Transport Azurophil Granule Protein Transport	Regulation Of Thymocyte Migration Central Tolerance Induction To Self Antigen Central Tolerance Induction Tolerance Induction Dependent Upon Immune Response Thymus Epithelium Morphogenesis Peripheral T Cell Tolerance Induction Protein Kinase CK2 Complex Symbiont-mediated Disruption Of Host Cell PML Body Viral Process Semicircular Canal Formation Abducens Nerve Formation Optokinetic Behavior Identical Protein Binding Tolerance Induction To Self Antigen Release From Viral Latency T Cell Tolerance Induction Positive Regulation Of Activin Receptor Signaling Pathway Negative Regulation Of Viral Life Cycle Adiponectin-activated Signaling Pathway Formation Of Translation Preinitiation Complex Embryonic Neurocranium Morphogenesis Outer Ear Morphogenesis Negative Thymic T Cell Selection Negative T Cell Selection Female Germ Cell Nucleus Tube Morphogenesis Endothelial Tube Morphogenesis IRES-dependent Viral Translational Initiation
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