C1QTNF2 and KCNIP3

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		C1QTNF2	KCNIP3
Description		C1q and TNF related 2	potassium voltage-gated channel interacting protein 3
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Collagen Trimer	Nucleus Cytoplasm Endoplasmic Reticulum Golgi Apparatus Cytosol Plasma Membrane Voltage-gated Potassium Channel Complex Membrane Monoatomic Ion Channel Complex
	Molecular Function	Protein Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Potassium Channel Activity Calcium Ion Binding Protein Binding Potassium Channel Regulator Activity Metal Ion Binding
	Biological Process	Regulation Of Lipid Metabolic Process	Negative Regulation Of Transcription By RNA Polymerase II Monoatomic Ion Transport Potassium Ion Transport Apoptotic Process Signal Transduction Regulation Of Signal Transduction Monoatomic Ion Transmembrane Transport Potassium Ion Transmembrane Transport Protein Localization To Plasma Membrane Regulation Of Potassium Ion Transmembrane Transport
Pathways			Phase 1 - inactivation of fast Na+ channels Regulation of NPAS4 gene transcription
Drugs
Diseases
GWAS		Weight loss (gastric bypass surgery) ( 23643386)	Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892)
Interacting Genes		24 interacting genes: AIRIM ANKRD11 BANP CHIC2 GPANK1 HPCA HPCAL1 KCNIP3 KLHL12 LCK LGALS14 MTX2 NCALD NCS1 NOL4 P4HA3 PHOSPHO2 TCEANC TIMM8A TRIM54 UBQLN1 UBQLN2 USP20 VSNL1	26 interacting genes: ASPH C1QTNF2 CALM2 CASP3 CD177 CDSN CLN3 CREB1 CREM CTBP2 GOLGA7 GRK2 GRK6 IGF1R IGLV3-25 IL6ST KHDC4 MAVS PCBD2 PPP3CA PSEN1 PSEN2 SOD3 SRL TARBP2 ZG16
Entrez ID		114898	30818
HPRD ID		12715	05232
Ensembl ID		ENSG00000145861	ENSG00000115041
Uniprot IDs		A0A499FIM1 Q9BXJ5	Q9Y2W7
PDB IDs			2E6W
Enriched GO Terms of Interacting Partners?			Amyloid Precursor Protein Catabolic Process Skeletal Muscle Tissue Regeneration Amyloid Precursor Protein Metabolic Process Beta-adrenergic Receptor Kinase Activity Regulation Of Transport ATF4-CREB1 Transcription Factor Complex Regulation Of Cell Communication Positive Regulation Of Transport G Protein-coupled Receptor Kinase Activity Regulation Of Muscle System Process Intracellular Signal Transduction Death-inducing Signaling Complex Regulation Of Neuron Apoptotic Process Gamma-secretase Complex Aspartic Endopeptidase Activity, Intramembrane Cleaving Regulation Of Calcium Ion Transmembrane Transport CAMP/PKA Signal Transduction Tissue Regeneration Notch Receptor Processing Response To Hypoxia Sarcoplasmic Reticulum Lumen Response To Decreased Oxygen Levels Amyloid-beta Formation Response To Metal Ion Keratinocyte Differentiation Signal Transduction Response To Oxygen Levels Protein Processing Skin Morphogenesis Regulation Of Signaling Detection Of Calcium Ion Regulation Of Synaptic Vesicle Cycle Calcium-dependent Protein Binding Regulation Of Cell Communication By Electrical Coupling Regulation Of Synaptic Plasticity Death Receptor Binding Membrane Raft Calcium Ion Homeostasis Negative Regulation Of Programmed Cell Death Positive Regulation Of Intracellular Protein Transport Regulation Of Calcium Ion Transport Viral Genome Replication Aspartic-type Endopeptidase Activity Regulation Of Striated Muscle Contraction Epidermal Cell Differentiation Calcium Ion Transport Positive Regulation Of Protein Transport Cell Surface Receptor Signaling Pathway Membrane Protein Ectodomain Proteolysis Muscle System Process
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