TMEM200A and UNC119

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		TMEM200A	UNC119
Description		transmembrane protein 200A	unc-119 lipid binding chaperone
Image		No pdb structure
GO Annotations	Cellular Component	Membrane	Spindle Pole Cytoplasm Centrosome Spindle Cytosol Cytoskeleton Intercellular Bridge Synapse Spindle Midzone
	Molecular Function	Protein Binding	Protein Binding Lipid Binding
	Biological Process		Mitotic Cytokinesis Endocytosis Chemical Synaptic Transmission Nervous System Development Visual Perception Phototransduction Protein Transport Lipoprotein Transport Positive Regulation Of Protein Tyrosine Kinase Activity Negative Regulation Of Clathrin-dependent Endocytosis Negative Regulation Of Caveolin-mediated Endocytosis
Pathways
Drugs
Diseases
GWAS		Colorectal cancer (calcium intake interaction) ( 25192705) Exploratory eye movement dysfunction in schizophrenia (cognitive search score) ( 26242244) Exploratory eye movement dysfunction in schizophrenia (number of eye fixations) ( 26242244) Exploratory eye movement dysfunction in schizophrenia (responsive search score) ( 26242244)
Interacting Genes		4 interacting genes: BCL2L10 CNIH2 EMD UNC119	104 interacting genes: AAGAB ALDH2 AMOT ANKRD24 ANXA1 ANXA3 ANXA7 ARL15 ARL2 ARL3 ARL4D ASH2L BCR BRIX1 BTBD2 C16orf74 CBX8 CCL18 CD247 CD3E CD4 CDC42 CDKN1A CDKN2C CETN3 CFTR CKMT2 CKS2 COX17 CYB561D2 EIF2S2 ERH FKBPL FXYD6 FYN GIPC2 GSTM4 HCK HLA-DQA1 HMGB1 HSPB3 HSPE1 ID2 IL5RA ITSN1 KDM1A KRTAP1-3 KRTAP9-3 KRTAP9-8 LAMA4 LCK LIG4 LRIF1 LUC7L2 LYN MAP3K20 MAPK10 MAPK8IP2 MPHOSPH6 MRPS12 ORAI2 PAFAH1B3 PAPSS1 PCDHA4 PFN1 PHF10 PIN1 PLPP2 PPA1 PPP3CA PPP3CC PSMD11 PSMD2 PTPRS QTRT1 RAP1B RASSF6 RBPMS2 RCAN3 RCC1 RFC5 RGL2 RPA2 RPS6KA5 RUFY3 S100A4 S100A8 SAT1 SEPHS1 SERPINB9 SMN1 SULT1E1 TK1 TMEM200A TP53BP2 TP53I3 TP53INP1 TRDMT1 TSC22D1 UBE2B UBE2I UBQLN4 ZFP64 ZNF24
Entrez ID		114801	9094
HPRD ID		13901	04927
Ensembl ID		ENSG00000164484	ENSG00000109103
Uniprot IDs		Q86VY9	K7EN86 Q13432
PDB IDs			3GQQ 3RBQ 4GOJ 4GOK 5L7K 6H6A 7UMO 9GKG
Enriched GO Terms of Interacting Partners?		Spindle TMEM240-body Negative Regulation Of Caveolin-mediated Endocytosis Cortical Endoplasmic Reticulum Nuclear Membrane Negative Regulation Of Clathrin-dependent Endocytosis Regulation Of Caveolin-mediated Endocytosis Positive Regulation Of Protein Tyrosine Kinase Activity Trans-synaptic Signaling Synaptic Signaling Chemical Synaptic Transmission Regulation Of AMPA Receptor Activity Endoplasmic Reticulum Regulation Of Transport Caspase Binding Spindle Pole Centrosome Lipoprotein Transport Regulation Of Clathrin-dependent Endocytosis Regulation Of Neurotransmitter Receptor Activity	Fc-gamma Receptor Signaling Pathway Fc Receptor Signaling Pathway Positive Regulation Of Cell Population Proliferation Positive Regulation Of Leukocyte Proliferation Positive Regulation Of Lymphocyte Activation Positive Regulation Of T Cell Activation Positive Regulation Of Leukocyte Cell-cell Adhesion Glutamatergic Synapse Leukocyte Migration Positive Regulation Of Cell Activation Cytosol Enzyme Binding Positive Regulation Of Cell-cell Adhesion Protein Binding T Cell Receptor Binding RAGE Receptor Binding Positive Regulation Of Cell Adhesion Intracellular Signal Transduction Regulation Of Lymphocyte Activation Positive Regulation Of Cell Development Regulation Of Calcium Ion Import Across Plasma Membrane Cytoplasm Nucleus T Cell Activation Positive Regulation Of Monoatomic Ion Transmembrane Transport Gamma-delta T Cell Receptor Complex Lymphocyte Activation Regulation Of Leukocyte Cell-cell Adhesion Calcium-dependent Protein Binding Regulation Of T Cell Activation Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Cellular Developmental Process T Cell Costimulation Positive Regulation Of Leukocyte Differentiation T Cell Receptor Complex Intracellular Signaling Cassette CD8 Receptor Binding Nucleotide Binding Gamma-delta T Cell Activation Negative Regulation Of Cell Development Peptidyl-tyrosine Phosphorylation Regulation Of Mitotic Cell Cycle Phagocytosis Regulation Of Leukocyte Proliferation Response To Gamma Radiation Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Positive Regulation Of Lymphocyte Proliferation Positive Regulation Of Mononuclear Cell Proliferation Schaffer Collateral - CA1 Synapse
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