NLRP3 and CSNK1A1

Number of citations of the paper that reports this interaction (PubMedID 34615873)
43

Data Source:
BioGRID (enzymatic study, affinity chromatography technology)

		NLRP3	CSNK1A1
Description		NLR family pyrin domain containing 3	casein kinase 1 alpha 1
Image
GO Annotations	Cellular Component	Golgi Membrane Extracellular Region Nucleus Cytoplasm Mitochondrion Endoplasmic Reticulum Golgi Apparatus Microtubule Organizing Center Cytosol Cytoskeleton Membrane Interphase Microtubule Organizing Center Canonical Inflammasome Complex NLRP3 Inflammasome Complex	Chromosome, Centromeric Region Kinetochore Nucleus Chromosome Cytoplasm Centrosome Spindle Cytosol MRNA Cleavage And Polyadenylation Specificity Factor Complex Cytoskeleton Cilium Membrane Nuclear Speck Beta-catenin Destruction Complex Ciliary Basal Body Cell Projection Keratin Filament
	Molecular Function	Nucleotide Binding Protein Binding ATP Binding Hydrolase Activity ATP Hydrolysis Activity Protein-macromolecule Adaptor Activity Signaling Adaptor Activity Identical Protein Binding Peptidoglycan Binding ADP Binding Sequence-specific DNA Binding Molecular Adaptor Activity Phosphatidylinositol-4-phosphate Binding DNA-binding Transcription Factor Binding Molecular Sensor Activity Cysteine-type Endopeptidase Activator Activity Molecular Condensate Scaffold Activity Phosphatidylinositol Phosphate Binding	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Serine Kinase Activity
	Biological Process	Pattern Recognition Receptor Signaling Pathway Immune System Process Negative Regulation Of Acute Inflammatory Response Positive Regulation Of Type 2 Immune Response Regulation Of DNA-templated Transcription Apoptotic Process Defense Response Inflammatory Response Signal Transduction Osmosensory Signaling Pathway Protein Secretion Detection Of Biotic Stimulus Response To Virus Negative Regulation Of Interleukin-1 Beta Production Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Interleukin-18 Production Positive Regulation Of Interleukin-4 Production Interleukin-18-mediated Signaling Pathway NLRP3 Inflammasome Complex Assembly Innate Immune Response Positive Regulation Of T-helper 2 Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Inflammatory Response Negative Regulation Of Inflammatory Response Positive Regulation Of Inflammatory Response Positive Regulation Of NF-kappaB Transcription Factor Activity Protein Homooligomerization Protein Maturation Pyroptotic Inflammatory Response Interleukin-1-mediated Signaling Pathway Cellular Response To Lipopolysaccharide Cellular Response To Virus Positive Regulation Of NLRP3 Inflammasome Complex Assembly Negative Regulation Of Non-canonical NF-kappaB Signal Transduction Positive Regulation Of Non-canonical NF-kappaB Signal Transduction Positive Regulation Of T-helper 2 Cell Cytokine Production	Autophagosome Assembly Protein Phosphorylation Golgi Organization Signal Transduction Cell Surface Receptor Signaling Pathway Negative Regulation Of Autophagy Positive Regulation Of Autophagy Wnt Signaling Pathway Viral Protein Processing Regulation Of Wnt Signaling Pathway SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Cellular Response To Nutrient Levels Cellular Response To Nutrient Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Rho Protein Signal Transduction TORC1 Signaling Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process NLRP3 Inflammasome Complex Assembly Intermediate Filament Cytoskeleton Organization Cell Division Negative Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of NLRP3 Inflammasome Complex Assembly Positive Regulation Of NLRP3 Inflammasome Complex Assembly Negative Regulation Of TORC1 Signaling Positive Regulation Of TORC1 Signaling
Pathways		Metalloprotease DUBs The NLRP3 inflammasome The NLRP3 inflammasome Purinergic signaling in leishmaniasis infection Purinergic signaling in leishmaniasis infection SARS-CoV-1 activates/modulates innate immune responses SARS-CoV-2 activates/modulates innate and adaptive immune responses Cytoprotection by HMOX1	Degradation of beta-catenin by the destruction complex Beta-catenin phosphorylation cascade Disassembly of the destruction complex and recruitment of AXIN to the membrane Disassembly of the destruction complex and recruitment of AXIN to the membrane Signaling by GSK3beta mutants CTNNB1 S33 mutants aren't phosphorylated CTNNB1 S37 mutants aren't phosphorylated CTNNB1 S45 mutants aren't phosphorylated CTNNB1 T41 mutants aren't phosphorylated APC truncation mutants have impaired AXIN binding AXIN missense mutants destabilize the destruction complex Truncations of AMER1 destabilize the destruction complex Degradation of GLI2 by the proteasome GLI3 is processed to GLI3R by the proteasome Activation of SMO Activation of SMO Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A Maturation of nucleoprotein
Drugs			Fostamatinib
Diseases		Cryopyrin associated periodic syndrome (CAPS), including the following three diseases: Muckle-Wells syndrome (MWS); Familial cold autoinflammatory syndrome (FCAS); Chronic infantile neurologic, cutaneous, articular (CINCA) syndrome
GWAS		Alanine aminotransferase levels ( 33547301) Aspartate aminotransferase levels ( 33547301) C-reactive protein levels ( 21300955 30388399) Fibrinogen ( 23969696 20031576) Fibrinogen levels ( 28107422 26561523) Granulocyte count ( 27863252) Liver enzyme levels (alanine transaminase) ( 33972514) Mean corpuscular hemoglobin ( 32888494) Monocyte percentage of white cells ( 32888494) Myeloid white cell count ( 27863252) Neutrophil count ( 32888494 27863252) Neutrophil percentage of white cells ( 27863252 32888494) Platelet count ( 27863252 32888494) Plateletcrit ( 32888494) Red cell distribution width ( 32888494) Serum alkaline phosphatase levels ( 33547301) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) Waist circumference adjusted for body mass index ( 25673412) White blood cell count ( 27863252 32888494) Word reading ( 23738518)	Carotid intima media thickness x smoking interaction ( 32117412) Chronic obstructive pulmonary disease ( 30804561) Esophageal cancer ( 21642993)
Interacting Genes		15 interacting genes: ANAPC10 ATP1B3 CARD8 CD82 CSNK1A1 CUL1 FAF1 FBXL2 HERC5 IRGM LAMTOR1 MARCHF7 MARK4 PGM1 PYCARD	51 interacting genes: ACTB ADAP1 AP3B1 AP3B2 APC ATM AXIN1 BID CDC25A CEBPA CHRM3 CRBN CREM CTNNB1 CUL4B EIF2B5 ERF FADD GLI3 GNB2 HMGB1 HMGB2 HNRNPC HSPA4 KPNA2 KPNB1 LGALS3 MDM4 NFATC3 NLRP3 OCLN PDE4D PHLPP1 PPP1CC PPP1R14A PPP2R5A PSEN2 PTEN RCC1 SLC18A2 SNCA SQSTM1 SYT9 TGFBR1 TIAM1 TNFRSF1B TP53 USP15 UVRAG YWHAQ YWHAZ
Entrez ID		114548	1452
HPRD ID		05915	02739
Ensembl ID		ENSG00000162711	ENSG00000113712
Uniprot IDs		A0A7I2PJH0 A0A7I2PMC6 A0A7I2PRX0 A0A7I2R3P8 Q96P20	B4DER9 P48729 Q6PJ06
PDB IDs		2NAQ 3QF2 6NPY 7ALV 7PZC 7PZD 7VTP 7ZGU 8EJ4 8ERT 8ETR 8RI2 8SWF 8SWK 8SXN 8WSM 8ZEM 9DH3 9GU4 9MGY 9MIE 9MIG	5FQD 6GZD 7WTT 8G66
Enriched GO Terms of Interacting Partners?		Negative Regulation Of NLRP3 Inflammasome Complex Assembly Regulation Of NLRP3 Inflammasome Complex Assembly Canonical Inflammasome Complex Assembly Negative Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Autophagy NLRP3 Inflammasome Complex Assembly Regulation Of Protein-containing Complex Assembly Autophagosome Assembly Autophagosome Organization Negative Regulation Of Intracellular Signal Transduction Protein Metabolic Process Modification-dependent Protein Catabolic Process Negative Regulation Of Protein-containing Complex Assembly Ubiquitin-dependent Protein Catabolic Process Regulation Of Canonical NF-kappaB Signal Transduction Protein Catabolic Process Regulation Of Intracellular Signal Transduction Vacuole Organization Macromolecule Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Protein Monoubiquitination Response To Virus SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein Modification Process TORC1 Signaling Lysosome Organization NLRP3 Inflammasome Complex Regulation Of Defense Response To Virus Proteolysis Cysteine-type Endopeptidase Activator Activity Proteasomal Protein Catabolic Process Intracellular Signal Transduction Post-translational Protein Modification TOR Signaling Canonical Inflammasome Complex CARD Domain Binding Catabolic Process Regulation Of TORC1 Signaling Negative Regulation Of Signal Transduction Defense Response To Virus Ubiquitin Binding Negative Regulation Of Autophagy Negative Regulation Of Cell Communication Negative Regulation Of Signaling Protein Ubiquitination Regulation Of Protein Metabolic Process Regulation Of Protein Serine/threonine Kinase Activity Innate Immune Response Protein Modification By Small Protein Conjugation	Protein-containing Complex Signal Transduction Regulation Of Apoptotic Process Intracellular Signal Transduction Regulation Of Programmed Cell Death Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Immune System Process Regulation Of Cell Development Ubiquitin Protein Ligase Binding Protein Domain Specific Binding Regulation Of Cell Activation Positive Regulation Of Apoptotic Process Positive Regulation Of Cell Development Cytosol Negative Regulation Of Signal Transduction Positive Regulation Of Programmed Cell Death Regulation Of Macromolecule Metabolic Process Cellular Component Assembly Negative Regulation Of Cell Communication Negative Regulation Of Signaling Positive Regulation Of Protein-containing Complex Assembly Positive Regulation Of Cell Differentiation Regulation Of RNA Metabolic Process Regulation Of T Cell Activation Regulation Of Metabolic Process Regulation Of Stem Cell Proliferation T Cell Differentiation In Thymus Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Cell Differentiation Regulation Of Lymphocyte Activation Regulation Of Primary Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Metabolic Process Regulation Of Hemopoiesis Positive Regulation Of Biosynthetic Process Positive Regulation Of Catabolic Process Regulation Of Cell Population Proliferation Lung Development Regulation Of Cellular Component Organization Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of Multicellular Organismal Process Positive Regulation Of DNA-templated Transcription Intracellular Signaling Cassette Cytoplasm Regulation Of Organelle Organization Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Nucleus Apoptotic Process
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